Exosome-Based Diagnostics: Emerging Tools for Early and Non-Invasive Disease Detection
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Exosomes are small extracellular vesicles secreted by parent cells into the extracellular environment. The biomoleculesthey carry—such as proteins, lipids, and nucleic acids—reflect the molecular profile of their cells of origin. Due to their stability in bodyfluids and close molecular resemblance to parent cells, exosomes have gained considerable attention as non-invasive biomarkers anddiagnostic tools for early and accurate disease detection. This review presents a comprehensive overview of exosome biology, includingtheir biogenesis, molecular composition, and related diagnostic biomarkers. We also summarize current exosome isolation methods andadvanced exosome-based diagnostic technologies—such as CRISPR/Cas systems, digital polymerase chain reaction, and surfaceenhancedRaman scattering (SERS)—emphasizing their potential for early, sensitive, and non-invasive disease diagnosis.
Abstract
Exosomes are small extracellular vesicles secreted by parent cells into the extracellular environment. The biomoleculesthey carry—such as proteins, lipids, and nucleic acids—reflect the molecular profile of their cells of origin. Due to their stability in bodyfluids and close molecular resemblance to parent cells, exosomes have gained considerable attention as non-invasive biomarkers anddiagnostic tools for early and accurate disease detection. This review presents a comprehensive overview of exosome biology, includingtheir biogenesis, molecular composition, and related diagnostic biomarkers. We also summarize current exosome isolation methods andadvanced exosome-based diagnostic technologies—such as CRISPR/Cas systems, digital polymerase chain reaction, and surfaceenhancedRaman scattering (SERS)—emphasizing their potential for early, sensitive, and non-invasive disease diagnosis.