Advanced Strategies for SERS Design as a Next-Generation Biosensing Platform: A Mini Review
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As human lifespans continue to increase, the demand for faster and more accurate medical diagnostics is also rising. Biosensors have evolved accordingly, and point-of-care systems such as rapid antigen tests and glucose monitors are now widelyadopted. However, the range of detectable biomolecules remains limited due to inadequate sensitivity and specificity. Among emergingtechnologies, surface-enhanced Raman spectroscopy (SERS) shows strong potential because of its exceptional sensitivity, specificity,and speed. SERS chips enable direct detection without sample pretreatment, offering significant advantages over conventionalmethods. Nonetheless, challenges remain in quantification and in distinguishing between structurally similar targets. To address theselimitations, recent research has focused on structural innovations—particularly nano-patterning and surface functionalization. Thesestrategies improve reproducibility and analytical precision, positioning SERS as a promising platform for next-generation biosensors. With continued advancement, SERS-based systems are poised to shape the future of medical diagnostics and play a key role in theFourth Industrial Revolution.
Abstract
As human lifespans continue to increase, the demand for faster and more accurate medical diagnostics is also rising. Biosensors have evolved accordingly, and point-of-care systems such as rapid antigen tests and glucose monitors are now widelyadopted. However, the range of detectable biomolecules remains limited due to inadequate sensitivity and specificity. Among emergingtechnologies, surface-enhanced Raman spectroscopy (SERS) shows strong potential because of its exceptional sensitivity, specificity,and speed. SERS chips enable direct detection without sample pretreatment, offering significant advantages over conventionalmethods. Nonetheless, challenges remain in quantification and in distinguishing between structurally similar targets. To address theselimitations, recent research has focused on structural innovations—particularly nano-patterning and surface functionalization. Thesestrategies improve reproducibility and analytical precision, positioning SERS as a promising platform for next-generation biosensors. With continued advancement, SERS-based systems are poised to shape the future of medical diagnostics and play a key role in theFourth Industrial Revolution.