기본섬유아세포 성장인자와 콜라겐 골격으로 치료한 난치성 성대 반흔 1예
A Case of Surgical Treatment of Intractable Vocal Fold Scar Using Basic Fibroblast Growth Factor and Collagen Scaffold
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Vocal fold scarring is an intractable phonosurgical condition. The number of patients with vocal fold scars is increasing with the aging of society and with the increasing application of laryngeal microsurgery. Many methods are available to treat these, including voice therapy, stem cells, regenerative scaffolds, and growth factors. However, no standard treatment strategy has yet been established, and novel techniques are required. Basic fibroblast growth factor has been shown to be effective for the treatment of mild chronic vocal fold scarring. The combined use of basic fibroblast growth factor and regenerative scaffolds is currently under investigation. Here, we report a female patient in whom vocal fold scarring developed after two laryngeal microsurgeries. We performed laryngeal microsurgery to remove the scar tissue and used basic fibroblast growth factor and a collagen scaffold to promote healing. The patient’s voice quality was greatly increased, and she was content with her voice after 2 years of follow-up. This is the first report of this methodology in Korea and is presented along with a review of the literature.
Abstract
Vocal fold scarring is an intractable phonosurgical condition. The number of patients with vocal fold scars is increasing with the aging of society and with the increasing application of laryngeal microsurgery. Many methods are available to treat these, including voice therapy, stem cells, regenerative scaffolds, and growth factors. However, no standard treatment strategy has yet been established, and novel techniques are required. Basic fibroblast growth factor has been shown to be effective for the treatment of mild chronic vocal fold scarring. The combined use of basic fibroblast growth factor and regenerative scaffolds is currently under investigation. Here, we report a female patient in whom vocal fold scarring developed after two laryngeal microsurgeries. We performed laryngeal microsurgery to remove the scar tissue and used basic fibroblast growth factor and a collagen scaffold to promote healing. The patient’s voice quality was greatly increased, and she was content with her voice after 2 years of follow-up. This is the first report of this methodology in Korea and is presented along with a review of the literature.
참고문헌 (7)
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- Kanemaru S, "Regeneration of the vocal fold using autologous mesenchymal stem cells", Ann Otol Rhinol Laryngol, 112(11), pp.915~920 (2003)
- Kishimoto Y, "Implantation of atelocollagen sheet for vocal fold scar", Curr Opin Otolaryngol Head Neck Surg, 18(6), pp.507~511 (2010)
- Tabata Y, "Biodegradation of hydrogel carrier incorporating fibroblast growth factor", Tissue Eng, 5(2), pp.127~138 (1999)