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內消和中湯加味方이 아토피피부염 환아의 혈중 Cytokine 분비에 미치는 영향

Effects of NaesowhajungtangGamibang on Serum Cytokines of patients with Atopic Dermatitis

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주제분류한의학

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Abstract

Objective: Based on the Th1/Th2 inbalance hypothesis, we aimed to evaluate the effects of NaesowhajungtangGamibang on serum interferon-γ, interleukin-4, interleukin-5 of 19 patients with atopic dermatitis. Materials & Methods: The subjects are consisted of 19 patients with atopic dermatitis, and had been treated with NaesowhajungtangGamibang decoction for 45 days. Serum IFN-γ, IL-4, IL-5 level were checked before and 45 days after treatments. Results: The serum IFN-γ, IL-5 level in patients with atopic dermatitis were slightly decreased compared with normal control group, but had no statistical significance. The serum IL-4 level in patients with atopic dermatitis was slightly increased compared with normal control group, but had no statistical significance. After treatment with NaesowhajungtangGamibang for 45 days, serum IFN-γ, IL-5 level were increased, but had no statistical significance. After treatment with NaesowhajungtangGamibang for 45 days, serum IL-4 level were decreased, but had no statistical significance. Conclusion: This study shows that NaesowhajungtangGamibang decoction has effects were not correspond with Th1/Th2 inbalance hypothesis. Therefore study for other mechanism of NaesowhajungtangGamibang on atopic dermatitis is required.

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