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沆瀣丹이 아토피 피부염 환자 단핵세포의 Cytokine 분비능에 미치는 영향

Effects of Hanghaedan on the cytokine secretory functionof monocytes of atopic dermatitis patients

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Abstract

Effects of Hanghaedan on the Cytokine Secretory Functionof Monocytes of Atopic Dermatitis Patients Kim Woo Yeoun, Lee Jin Yong Dept. of Oriental Medicine Graduate School of Kyung Hee Univ. Objetives The late research tendency on atopic dermatitis is mainly focused on the experiment of unbalance of cytokine released from T cell subtype. Methods As there’s no experiment with herbal medicine using Hanghaedan(HHD), we isolated and cultured monocytes of atopic dermatitis pateints (AD) peripheral blood, for knowing the influence of HHD on the secretory function of IL-4, IL-5, IFN-γ. Results 1. In AD group, HHD exhibits statistically significant inhibitory effect on IL-4(p<0.05). 2. In AD group, HHD exhibits statistically significant inhibitory effect on IL-5(p<0.05). 3. In AD group, HHD exhibits statistically significant inhibitory effect on IFN-γ (p<0.01). 4. Sample group comparing with the cytokine concentration rate value of AD patients and that of NAD patients IL-4 of AD patients exhibits statistically significant decrease(p<0.05). 5. In AD group, there is no significant relation between serum IgE and cytokines 6. In AD group, there is no significant relation between total eosinophil and IL-5. Conclusions Effects of Hanghaedan on the cytokine(IL-4, IL-5, IFN-γ) secretory function of monocytes of atopic dermatitis patients is recognized.

참고문헌 (46)

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