개별 열량 소비 트레이닝이 비만 어린이의 산화-항산화체계에 미치는 영향
The Effects of Individual Calory Consumption Training on Oxidation - Antioxidation System in Obese Children
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초록
본 연구는 남자초등학생을 비만군(n=20, 나이=11.15±1.42세)과 정상군(n=10, 나이=10.70±0.95세)으로 나누어 개별 열량 소비 트레이닝을 12주간 실시하여 산화-항산화체계에 미치는 영향을 비교하는데 목적이 있다. 신체구성, 호흡순환기능, 혈청지질, 항산화효소, 조직손상 인자들을 분석하였으며, 연구결과 비만군은 체지방률, 수축기와 이완기 혈압, TG, LDL-c, ox-LDL, 8-OHdG 등이 정상군에 비해 유의하게 높다는 것과 이에 반하여 HDL-c, 항산화효소인 SOD 수치는 정상군과 비교하여 유의하게 낮게 나타났다. 또한 12주간의 개별 열량 소비 트레이닝을 통해 정상군과 비만군 모두 ox-LDL 수치와 GPX활성이 유의하게 증가되었다. 따라서, 비만아동은 비만에 의한 조직손상과 항산화 방어 역량의 저하로 산화·항산화 체계의 불균형을 일으키며, 산화적 스트레스를 높여 혈관의 염증반응을 증가시켜 결국 혈관을 손상시키고 심혈관질환위험을 가속화시키는데 영항을 줄 수 있음을 시사한다. 또한 12주간의 개별 열량 소비 트레이닝을 통하여 항산화효소 활성에 긍정적인 영향을 주어 체내의 산화․환원의 체계를 정상화시켜 심혈관계 스트레스 감소에 긍정적인 영향을 줄 수 있을 것으로 사료된다.
Abstract
The purpose of this study was to compare the differences between before and after 12 week individual calory consumption training on oxidation-antioxidation in obese children. All the subjects divided into obese training group(n=20, age=11.15±1.42) and normal training group(n=10, age=10.70±0.95). Before and after training, we measured that body composition, cardio-pulmonary function, serum lipid, antioxidant enzyme, tissue damage factors. There were differences in body fat, VO2max, systolic and diastolic blood pressure, TG, HDL-c, LDL-c, ox-LDL, 8-OHdG, and SOD levels between groups. Also, there were differences in ox-LDL and GPX levels between pre and post. In conclusion, body fat, blood pressures, TG, LDL-c, ox-LDL, and 8-OHdG levels were higher and VO2max, HDL-c, and SOD levels were lower in obese children than in normal children. But, GPX activity in obese children with regular exercise were found to be similar to those of normal children. These results indicated that increased cardiovascular stress and antioxidant imbalace begins in childhood in obesity. However, individual calory consumption training can enhance antioxidant capacity in obese children.
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