샌달우드 오일의 항산화 및 항염증에 관한 효과
The Effect of Anti-oxidative and Anti-inflammatory Functional in SanDalWood oil
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SDWD의 항산화작용을 실험적으로 입증하고자 ICR계 생쥐에 AAPH를 복강에 주입하여 실험적 급성산화증을 유발시킨 후 AA와 SDWD를 투여한 후 혈액성분의 변화를 측정하여 다음과 같은 결론을 얻었다. 1. 백혈구수는 모든 SDWD군에서 대조군에 비하여 현저한 감소를 보였고, 혈소판수도 SDWD군에서 대조군에 비하여 유의하게 감소하였다. 2. Albumin과 uric acid는 모든 SDWD군에서 대조군에 비하여 유의하게 증가하였고, total billirubin은 20% SDWD군에서 대조군에 비하여 유의하게 증가하였다. 3. LDL cholesterol, BUN, glucose, TG는 모든 SDWD군에서 대조군에 비하여 유의하게 감소하였고, triglyceride는 모든 SDWD군에서 대조군에 비하여 유의하게 증가하였다. 4. 혈장내 cytokine 생산중 IL-1β는 20% SDWD군에서 대조군에 비하여 유의하게 감소하였고, IFN-γ는 모든 SDWD군에서 대조군에 비하여 유의하게 증가하였다.
Abstract
The purpose of this study is to investigate the anti-oxidant activities and anti-inflammatory activities of SanDalWood oil by experimental methods. We caused the acute oxidant symptom by the injection of AAPH into the mouses's abdominal cavity, and then applied the aroma SDWD oil inhalation, and finally, we measured the change of blood ingredient and the resistance against the activated oxygen of the red blood cell membrane. 1. The number of white blood cell and red blood cell was remarkably decreased in all handling groups of SDWD oil comparing with the control group and the number of red blood cell was meaningfully decreased in the 10% - handling group of SDWD oil comparing with the contrast group, and the pletelet did not showed the meaningful change. 2. The Albumin and the uric acid were meaningfully increased in all handling groups of SDWD oil as against the contrast group and the total billirubin did not showed the meaningful change. 3. Glucose, LDL cholesterol, BUN, and triglyceride (TG) were meaningfully decreased in all handling groups of SDWD oil in comparison with the contrast group and the total cholesterol did not showed the meaningful change. 4. IL-1β and IFN-γ among producing the cytokine inside the plasma was meaningfully dwindled in the 20% - handling group of SDWD oil comparing with the contrast group.
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