산마늘추출물이 과산화지질급여 비만쥐의 지질강하, 항산화효과 및 염증매개물질의 생산에 미치는 영향
Effects of Allium victorials Extract on Lowing Lipid, Anti-oxidation and Concentration of Inflammatory Mediators in Rats Fed High Oxidized Fat
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본 연구는 산마늘추출물이 과산화지질을 급여한 비만쥐의 지질강하, 항산화효과 및 염증매개물질의 생산에 미치는 영향을 검토했다. 그 결과 혈장 FFA, TG, totalcholesterol 및 LDL-cholesterol 농도는 산마늘추출물 처리군 들에서 감소했으며, 혈장HDL-cholesterol 농도는산마늘추출물 처리군 들에서 증가했다. 간장 내 totalcholesterol 농도 및 TG 농도는 산마늘추출물 처리군 들에서 감소하는 경향을 나타내었다. 혈장 및 간장의 TBARS농도는 산마늘추출물 처리군 모두가 대조군보다 낮은 경향을 보였다. 간장 GSH-Px, SOD 및 CAT활성치모두가 산마늘추출물 처리군 들에서 증가하는 경향을 보였다. 혈장NO, Ceruloplasmin 및 α1-acid glycoprotein 농도는 산마늘추출물 투여군 들이 대조군보다 낮은 경향을 나타내었다. 이와 같은 결과는 산마늘추출물에 지질강하, 항산화 및항염증작용에 효과를 나타내는 기능성물질이 내재하고 있음을 시사한다.
Abstract
This study was carried out to effects of Allium victorials extract on lowering lipid, anti-oxidation andconcentration of inflammatory mediators in rats fed high oxidized fat. Concentration of free fatty acid(FFA),triglyceride(TG), total cholesterol and LDL-cholesterol in plasma decreased in the Allium victorials extract groups andplasma HDL-cholesterol concentration revealed a tendency to increase in Allium victorials extract groups. Concentration oftotal cholesterol and TG in liver showed a tendency to decrease in Allium victorials extract groups. Concentration ofthiobarbituric acid(TBARS) in plasma and liver showed a lower values in Allium victorials extract groups than that ofcontrol group. Activities of glutathione peroxidase(GSH-Px), superoxide dismutase(SOD) and catalase(CAT) in livershowed a tendency to increase in Allium victorials extract groups. Concentration of nitrogen oxide(NO), ceruloplasmin and α1-acid glycoprotein in plasma showed a lower values in Allium victorials extract groups than that of control group. Theseresults indicate that the Allium victorials extract have an functional material for lowering lipid, anti-oxidation andanti-inflammatory effect.
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