고수(Coriandrum sativum L.) 지상부 추출물의 항산화 및 항염증 활성 효과
Anti-oxidant and Anti-inflammatory Effects of Ethanol Extracts from Aerial Part of Coriandrum sativum L.
1
조회
0
다운로드
3
인용
0
참고문헌
키워드
초록
Coriandrum sativum L., an annual herbaceous plant of Apiaceae family. The present study evaluated the anti-oxidant activities and anti-inflammatory effects of ethanol extracts of C. sativum. The anti-oxidant activities of C. sativum were measured by total contents of polyphenol, flavonoid, DPPH and ABTS radical scavenging and reducing power activity. And anti-inflammatory effects of C. sativum were measured by LPS-induced RAW 264.7 cells. The results showed that the contents of total polyphenol and flavonoid were 76.03±1.36 mg of gallic acid equivalents/g and 182.23±4.32 mg of rutin equivalents/g at concentration 1 mg/ mL of C. sativum. The DPPH radical scavenging activity was found to be 52.8% at 500 µg/mL. The ABTS radical scavenging activity was shown in 58.3% after exposure to 1,000 µg/mL. Reducing power activity was found to be 66.8% at 2,000 µg/mL. The inhibitory effect of NO production was found to be 65% concentration 500 µg/mL. In the generation quantity of inflammatory cytokines such as TNF-α and IL-1β in cell culture medium, the expression levels of inflammatory proteins in cells were showed decrease with the increase of concentration. Therefore, we suggest that the C. sativum should be a potential source of alternative anti-inflammatory drug with good anti-inflammatory effects.
Abstract
Coriandrum sativum L., an annual herbaceous plant of Apiaceae family. The present study evaluated the anti-oxidant activities and anti-inflammatory effects of ethanol extracts of C. sativum. The anti-oxidant activities of C. sativum were measured by total contents of polyphenol, flavonoid, DPPH and ABTS radical scavenging and reducing power activity. And anti-inflammatory effects of C. sativum were measured by LPS-induced RAW 264.7 cells. The results showed that the contents of total polyphenol and flavonoid were 76.03±1.36 mg of gallic acid equivalents/g and 182.23±4.32 mg of rutin equivalents/g at concentration 1 mg/ mL of C. sativum. The DPPH radical scavenging activity was found to be 52.8% at 500 µg/mL. The ABTS radical scavenging activity was shown in 58.3% after exposure to 1,000 µg/mL. Reducing power activity was found to be 66.8% at 2,000 µg/mL. The inhibitory effect of NO production was found to be 65% concentration 500 µg/mL. In the generation quantity of inflammatory cytokines such as TNF-α and IL-1β in cell culture medium, the expression levels of inflammatory proteins in cells were showed decrease with the increase of concentration. Therefore, we suggest that the C. sativum should be a potential source of alternative anti-inflammatory drug with good anti-inflammatory effects.
참고문헌 (37)
- Azizi, G., "The role of inflammatory mediators in the pathogenesis of Alzheimer’s disease", Sultan Qaboos Univ Med J, 15, pp.305~316 (2015)
- Aktan, F., "iNOS-mediated nitric oxide production and its regulation", Life Sci, 75, pp.639~653 (2004)
- Chae, S. K., "Standard food analysis", pp.381~382 (2002)
- 차배천, "야생복숭아 나무 추출물의 항산화 및 항염증 효과", 한국약용작물학회지, 12(4), pp.289~294 (2004), 한국약용작물학회
- Chaudhry, N., "Bactericidal activity of black pepper, bay leaf, aniseed and coriander against oral isolates", Pak J Pharm Sci, 19, pp.214~218.9 (2006)
- Grabowski, P. S., "Immunolocalization of inducible nitric oxide synthase in synoviumand cartilage in rheumatoid arthritis and osteoarthritis", Br J Rheumatol, 36, pp.651~655 (1997)
- Han, J. T., "Development of functional material using the root of Rosa multiflora", Food Ind Nutri, 11, pp.59~65 (2006)
- Hou, X. M., "Signaling pathways that facilitate chronic inflammation-induced carcinogenesis", J Cell Signal, 1, pp.1~9 (2016)
- Hotamisligil, G. S., "Inflammation and metabolic disorders", Nature, 444, pp.860~867 (2006)
- Harris, J., "Autophagy controls IL-1β secretion by targeting Pro-IL-1β for degradation", J Bio Chem, 286, pp.9587~9597 (2011)[DOI]
- Ishida, M., "Immunostimulatory effect of aqueous extract of Coriandrum sativum L. seed on macrophages", J Sci Food Aqric, 97, pp.4727~4736 (2017)
- Jayalakshmi, C. P., "Effect of butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) on rat erythrocytes", Environ Res, 41, pp.235~238 (1986)
- 장상훈, "수확시기별, 부위별 선학초의 폴리페놀함량 및 DPPH 라디컬 소거능의 변화", 한국약용작물학회지, 16(6), pp.397~401 (2008), 한국약용작물학회
- Jing, L. L., "Antioxidant potential, total phenolic and total flavonoid contents of Rhododendron anthopogonoides and its protective effect on hypoxia-induced injury in PC12 cells", BMC Complement Altern Med, 15, pp.287~299 (2015)
- 주미선, "玄之草의 鎭痛 및 抗炎症 효과", 대한본초학회지, 25(3), pp.97~101 (2010), 대한본초학회
- Kaminska, B., "MAPK signaling pathways as molecular targets for anti-inflammatory therapy-from molecular mechanisms to therapeutic benefits", Biochim Biophys Acta, 1754, pp.253~262 (2005)
- Kamel, M., "Antioxidant activity of methanolic extracts from three coriander (Coriandrum sativum L.) fruit varieties", Arabian J Chem, 10, pp.3176~3183 (2013)
- 김정숙, "인진호 추출물의 항산화활성 및 항염효과", 아시안뷰티화장품학술지, 13(6), pp.805~812 (2015), 한국피부과학연구원
- 김기호, "더덕 잎의 파이토케미컬(phytochemicals)과 항산화 활성", 한국식품과학회지, 47(5), pp.680~685 (2015), 한국식품과학회[DOI]
- Laroux, F. S., "Role of nitric oxide in inflammation", Acta Physiol. Scand, 173, pp.113~118 (2001)
- 임현희, "천궁 및 당귀를 함유한 한방처방제 휘발성 향기추출물의 항염증 효과", 대한화장품학회지, 37(3), pp.199~210 (2011), 사단법인 대한화장품학회
- 이정희, "감잎추출물의 항산화 및 항염증 효과", 아시안뷰티화장품학술지, 12(5), pp.719~724 (2014), 한국피부과학연구원
- 이혜진, "비수리 추출물의 항균 및 항산화 활성", 한국미생물·생명공학회지, 39(1), pp.63~69 (2011), 한국미생물·생명공학회
- Lu, X. G., "Heliangin inhibited lipopolysaccharide-induced inflammation through signaling NF-κB pathway on LPS-induced RAW 264.7 cells", Bio Phar, 88, pp.102~108 (2017)
- Lawrence, T., "The nuclear factor NF-kappaB pathway in inflammation", Cold Spring Harb Perspect Biol, 1, pp.a001651~ (2009)
- Liu, J., "Stauntoside B inhibits macrophage activation by inhibiting NF-κB and ERK MAPK signaling", Pharmacol Res, 111, pp.303~315 (2016)
- Mantovani, A., "Cancer-related inflammation", Nature, 454, pp.436~444 (2008)
- Moynagh, P. N., "The NF-κB pathway", J Cell Sci, 118, pp.4389~4392 (2005)
- Oyaizu, M., "Studies on products of browning reaction : Antioxidant activities of products of browning reaction prepared from glucosamine", Eiyogaku zasshi, 44, pp.307~315 (1999)
- Popa, C., "The role of TNF-a in chronic inflammatory conditions, intermediary metabolism, and cardiovascular risk", J Lip Rese, 48, pp.751~762 (2007)
- Roberta, R., "Antioxidant activity applying an improved ATBS redical cation decolorization assay", Free Radic Biol Med, 26, pp.1231~1237 (1999)
- Ranganathan, P. V., "Netrin-1regulates the inflammatory response of neutrophils and macrophages, and suppresses ischemic acute kidney injury by inhibiting COX-2 mediated PGE2 production", Kidney Int, 83, pp.1087~1098 (2013)
- Sathishkumar, P., "Anti-acne, anti-dandruff and anti-breast cancer efficacy of green synthesised silver nanoparticles using Coriandrum sativum leaf extract", J Photochem Photobiol B, 163, pp.69~76 (2016)
- Tang, E. L., "Antioxidant activity of Coriandrum sativum and protection against DNA damage and cancer cell migration", BMC Complement Altern Med, 13, pp.347~360 (2013)
- Velioglu, Y., "Antioxidant activity and total phenolics in selected fruits, vegetables, and grain products", J Agric Food Chem, 46, pp.4113~4117 (1988)
- Yang, Y., "The study on the extraction and antioxidative activity in vitro of flavonoids from coriander", Chi F Addi, 6, pp.114~119 (2015)
- Zillich, O. V., "Polyphenols as active ingredients for cosmetic products", Int J Cosmet Sci, 37, pp.455~464 (2015)