각질형성세포에서 알파망고스틴의 Keratin1, Involucrin, Loricrin 유전자 발현 촉진 및 손톱윤기 개선 효과
Effects of α-Mangostin on Gene Expression of Keratin1, Involucrin, and Loricrin in HaCaT Keratinocytes and Improvement of Nail Gloss
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Skin is the largest organ of the human body, which surrounds and protects body from external environments. Skin is divided in epidermis and dermis layer, and especially, epidermis is composed three layers each known as spinous, granular and cornified layer. Though various cell types constitute epidermis such as melanocytes, keratinocytes and langerhans cells, over 95% of epidermis consists of keratinocytes. As differentiation arise, the major component of epidermis, keratinocytes gradually proceed differentiated state from cell cycle. The differentiation of keratinocytes is the most important functional role in formation of stratum corneum, thus protects body from microbial invasion and inhibits hydration of skin. Due to diverse function of skin biology, keratinocytes has been studied mainly in pathology about toxicology, chemicals, and cosmetology. Alpha-mangostin (α-mangostin) is a yellow colored agent, which is the first xanthone isolated from Garcinia mangostana (mangosteen). According to previous study, α-mangostin has biological effects such as anti-inflammation and antioxidant properties. The aim of this study was to investigate how α-mangostin promotes calcium induced differentiation of human epidermal keratinocytes, HaCaTs, and improves gloss of the nail.
Abstract
Skin is the largest organ of the human body, which surrounds and protects body from external environments. Skin is divided in epidermis and dermis layer, and especially, epidermis is composed three layers each known as spinous, granular and cornified layer. Though various cell types constitute epidermis such as melanocytes, keratinocytes and langerhans cells, over 95% of epidermis consists of keratinocytes. As differentiation arise, the major component of epidermis, keratinocytes gradually proceed differentiated state from cell cycle. The differentiation of keratinocytes is the most important functional role in formation of stratum corneum, thus protects body from microbial invasion and inhibits hydration of skin. Due to diverse function of skin biology, keratinocytes has been studied mainly in pathology about toxicology, chemicals, and cosmetology. Alpha-mangostin (α-mangostin) is a yellow colored agent, which is the first xanthone isolated from Garcinia mangostana (mangosteen). According to previous study, α-mangostin has biological effects such as anti-inflammation and antioxidant properties. The aim of this study was to investigate how α-mangostin promotes calcium induced differentiation of human epidermal keratinocytes, HaCaTs, and improves gloss of the nail.
참고문헌 (18)
- Bikle DD, "Changes in calcium responsiveness and handling during keratinocyte differentiation. Potential role of the calcium receptor", J. Clin. Invest, 97, pp.1085~1093 (1996)
- Mabel Buelna-Chontal, "Protective Effect of α-Mangostin on Cardiac Reperfusion Damage by Attenuation of Oxidative Stress", Journal of Medicinal Food, 14(11), pp.1370~1374 (2011), 한국식품영양과학회
- Chen LG, "Anti-inflammatory activity of mangostins from Garcinia mangostana", Food and Chem. Toxicol, 46, pp.688~693 (2008)
- 최문주, "Immortalization of Primary Keratinocytes and Its Application to Skin Research", Biomolecules & Therapeutics, 23(5), pp.391~399 (2015), 한국응용약물학회
- Choi YH, "α-Mangostin Regulates Hepatic Steatosis and Obesity through SirT1-AMPK and PPARγ Pathways in High-Fat Diet-Induced Obese Mice", J. Agric. Food Chem, 63, pp.8399~8406 (2015)
- De Berker DAR, "Nail biology and nail science", Int. J. Cosmetic Sci, 29, pp.241~275 (2007)
- Hennings H, "Calcium regulation of cellcell contact and differentiation of epidermal cells in culture", An ultrastructural study. Exp. Cell Res, 143, pp.127~142 (1983)
- Jariyapongskul A, "Alpha-mangostin attenuation of hyperglycemia-induced ocular hypoperfusion and blood retinal barrier leakage in the early stage of type 2 diabetes rats", Biomed. Res. Int, 2015, pp.785826~ (2015)
- Khengar RH, "Nail swelling as a pre-formulation screen for the selection and optimisation of ungual penetration enhancers", Pharm. Res, 24, pp.2207~2212 (2007)
- Livak KJ, "Analysis of relative gene expression data using real-time quantitative PCR and the 2 (-Delta Delta C (T)) Method", Methods, 25, pp.402~408 (2001)
- Mahabusarakam W, "Inhibition of lipoprotein oxidation by prenylated xanthones derived from mangostin", Free Radical Res, 33, pp.643~659 (2000)
- Mak VH, "Barrier function of human keratinocyte cultures grown at the air-liquid interface", J. Invest. Dermatol, 96, pp.323~327 (1991)
- Nakatani K, "Inhibitions of histamine release and prostaglandin E2 synthesis by mangosteen, a Thai medicinal plant", Biological and Pharmaceutical Bulletin, 25, pp.1137~1141 (2002)
- Pedraza-Chaverri J, "Medicinal properties of mangosteen (Garcinia mangostana)", Food and Chem. Toxicol, 46, pp.3227~3239 (2008)
- Perrin C., "Expression of follicular sheath keratins in the normal nail with special reference to the morphological analysis of the distal nail unit", Am. J. Dermatopathol, 29, pp.543~550 (2007)
- Tu CL, "Role of the calcium-sensing receptor in calcium regulation of epidermal differentiation and function", Best Pract. Res. Clin. Endocrinol. Metab, 27, pp.415~427 (2013)
- Williams P, "Mangostin inhibits the oxidative modification of human low density lipoprotein", Free Radical Res, 23, pp.175~184 (1995)
- Woelfle U, "Triterpenes promote keratinocyte differentiation in vitro, ex vivo and in vivo: a role for the transient receptor potential canonical (subtype) 6", J. Invest. Dermatol, 130, pp.113~123 (2010)