Alliin을 함유한 화장료 조성물이 중년여성의 주름, 탄력 개선에미치는 효과
Effects of Alliin-contained Cosmetic Composition on Wrinkle, Elasticity Improvement in Middle-aged Female
0
조회
0
다운로드
4
인용
0
참고문헌
키워드
초록
In our previous study, we show that alliin increased collagen in dermal fibroblasts and efficiently decreased MMP-1. Since collagen and MMP-1 are implicated in regulation wrinkle formation. Therefore, in present study, we show whether alliin decreased wrinkles and elasticity in human skin. The clinical trial was conducted with the women in 40s-50s who met the selection and exclusion criteria, by dividing them into the control group of 20 that use the cream that does not contain alliin and the experiment group of 20 that use the cream that contains alliin. The measurements were taken at prior to product use, and in 2 weeks and 4 weeks of product use. The results of the analysis in the improvement rate of the length of crow’s feet showed that the experiment group had an increase by 12.88% in 2 weeks of use, and 22.14% in 4 weeks of use. The results of the analysis on the improvement rate of the area of the crow’s feet showed that the experiment group had an increase by 15.35% in 2 weeks of use, and 26.44% in 4 weeks of use. The results of the analysis on the improvement rate of the number of wrinkles under eyes showed the increase by 33.33% in 2 weeks of use, and 46.46% in 4 weeks of use. The results of analysis on the improvement rate of skin elasticity showed the increase by 26.20% in 2 weeks of use, and 44.15% in 4 weeks of use. The results show that alliin is efficacious in improving skin in terms of wrinkles, elasticity. Thus, the effect of alliin in improving aged skin was demonstrated in the clinical trial, and alliin is expected to have a value as an excellent anti-aging ingredient for functional cosmetics.
Abstract
In our previous study, we show that alliin increased collagen in dermal fibroblasts and efficiently decreased MMP-1. Since collagen and MMP-1 are implicated in regulation wrinkle formation. Therefore, in present study, we show whether alliin decreased wrinkles and elasticity in human skin. The clinical trial was conducted with the women in 40s-50s who met the selection and exclusion criteria, by dividing them into the control group of 20 that use the cream that does not contain alliin and the experiment group of 20 that use the cream that contains alliin. The measurements were taken at prior to product use, and in 2 weeks and 4 weeks of product use. The results of the analysis in the improvement rate of the length of crow’s feet showed that the experiment group had an increase by 12.88% in 2 weeks of use, and 22.14% in 4 weeks of use. The results of the analysis on the improvement rate of the area of the crow’s feet showed that the experiment group had an increase by 15.35% in 2 weeks of use, and 26.44% in 4 weeks of use. The results of the analysis on the improvement rate of the number of wrinkles under eyes showed the increase by 33.33% in 2 weeks of use, and 46.46% in 4 weeks of use. The results of analysis on the improvement rate of skin elasticity showed the increase by 26.20% in 2 weeks of use, and 44.15% in 4 weeks of use. The results show that alliin is efficacious in improving skin in terms of wrinkles, elasticity. Thus, the effect of alliin in improving aged skin was demonstrated in the clinical trial, and alliin is expected to have a value as an excellent anti-aging ingredient for functional cosmetics.
참고문헌 (26)
- 김나미, "홍삼성분이 섬유아세포의 콜라겐 생합성과 MMP-I 활성에 미치는 영향", Journal of Ginseng Research, 31(2), pp.86~92 (2007), 고려인삼학회
- 김선희, "흑마늘 화장품의 주름개선 및 미백에 대한 피부미용 효과", 한국미용학회지, 15(3), pp.1041~1050 (2009), 한국미용학회
- 김민송, "20-50대 여성의 얼굴과 목 주름에 관한 인식 조사", 아시안뷰티화장품학술지, 10(3), pp.503~513 (2012), 주식회사 한국피부임상과학연구소
- 김민희, "한방화장품이 안면부의 탄력 개선에 미치는 영향", 한방안이비인후피부과학회지, 25(3), pp.150~159 (2012), 대한한방안이비인후피부과학회[DOI]
- 김명자, "홍삼식이가 여성의 혈액 및 피부개선에 미치는 효과", 한국미용학회지, 18(1), pp.159~168 (2012), 한국미용학회
- 서정화, "혈관 생리 활성에 미치는 alliin의 효능", 생명과학회지, 19(7), pp.976~982 (2009), 한국생명과학회
- 손명수, "홍삼에서 추출한 오일의 항산화 및 보습활성", 아시안뷰티화장품학술지, 11(3), pp.489~494 (2013), 주식회사 한국피부임상과학연구소
- 이정희, "오미자 추출물을 함유한 화장품의 중년 여성 안면주름 개선 효과", 한국미용학회지, 19(4), pp.634~641 (2013), 한국미용학회
- 정은영, "흑마늘 추출물을 첨가한 화장품의 기능성 평가: Tyrosinase와 Elastase 저해 활성 및 산화 스트레스에 미치는 영향 중심으로", 한국식품영양과학회지, 39(5), pp.662~668 (2010), 한국식품영양과학회
- 정희록, "생마늘 추출 숙성물의 항산화 및 아세틸콜린에스터라아제 저해 효과", 농업생명과학연구, 45(4), pp.113~120 (2011), 농업생명과학연구원
- Bhawan J, "Histopathologic differences in the photoing process in facial versus arm skin", Am. J. Dermatopathol, 14, pp.224~230 (1992)
- Barber LA, "Expression of the platelet-activating receptor results in enhanced ultraviolet B radiation-induced apoptosis in a human epidermal cell line", J. Biol. Chem, 273, pp.18891~18897 (1998)
- Brenneisen P, "Central role of ferrous", ferric iron in the ultraviolet B irradiation-mediated signaling pathway leading to increased interstitia collagenase (matrix-degrading metalloproteinase (MMP)-1 and stromelysin-1 (MMP-3) mRNA levels in cultured human dermal fibroblasts, 1998, pp.273, 5279~5287
- Banerjee SK, "Effect of garlic on cardiovascular disorders", Nutr. J, 19, pp.1~4 (2002)
- Castanet J, "Pigmentary changes is aged and photoaged skin", Arch. Dermatol, 133, pp.1296~1299 (1997)
- Fisher GJ, "Molecular basis of sun-induced premature skin ageing and retinoid antagonism", Nature, 379, pp.335~339 (1996)
- Kang S, "Topical N-acetyl cysteine and genistein prevent ultraviolet-light-induced signaling that leads to photoaging in human skin in vivo", J. Invest. Dermatol, 120, pp.835~841 (2003)
- Kovacs D, "Keratinocytes growth factor down-regulates intracellular ROS production induced by UVB", J. Dermatol. Sci, 54, pp.107~113 (2009)
- Lauer-Fields JL, "Matrix metalloproteinases and collagen catabolism", Biopol, 66, pp.19~32 (2002)
- Masaki H, "Detection of hydrogen peroxide and hydroxyl radicals in murine skin fibroblasts under UVB irradiation", Biochem. Biophys. Res. Commun, 206, pp.474~479 (1995)
- Stoll A, "Chemical investigations on alliin, the specific principle of garlic", Adv. Enzymol. Related Subjects of Biochem, 11, pp.377~400 (1951)
- Scharfferrs-Kichanek K, "UV-induced reactive oxygen species in photocarcinogenesis and photoing", Biol. Chem, 378, pp.1247~1257 (1997)
- Sallam KI, "Antioxidant and antimicrobial effects of garlic in chicken sausage", Lebensmittel-wissenschaff+〔i.e. und〕. Technol, 37, pp.849~855 (2004)
- Visse R, "Matrix metalloproteinases and tissue inhibitors of metalloproteinases: Structure, function, and biochemistry", Circul. Res, 92, pp.827~839 (2003)
- Yasui H, "Chemiluminescent detection and imaging of reactive oxygen species in live mouse skin exposed to UVA", Biochem. Biophys. Res. Commun, 269, pp.131~136 (2000)
- Yamamoto Y., "Role of active oxygen species and antioxidants in photoaging", J. Dermatol. Sci, 27, pp.1~4 (2001)