함초와 발효 함초 추출물의 화장품 소재로서 생리활성 비교연구

Abstract

This study aims to discover a possibility that ethanol and methanol extracts of dried and fermented Salicornia herbacea can be used as materials of cosmetics through bioactivity such as cytotoxicity, whitening activity, and antioxidation. As a result of the cytotoxicity which was carried targeting Raw 264.7 cell leave, it was discovered that there was no cytoxicity from the four extracts as cell survival rates of all the extracts were 106～133%. When the tyrosinase inhibitory activity for whitening was measured, all the four extracts had high inhibitory activity according to concentration and the inhibitory activity of ethanol extract of fermented S. herbacea was the highest. When DPPH radical scavenging effect for antioxidation was measured, the scavenging effect of ethanol extract of fermented S. herbacea was the highest. In particular, in comparison with antioxidative effect of BHT SC50 of 1.29 ㎎/㎖, that of fermented S. herbacea was similar, which indicates that it has a relatively high antioxidative effect. Therefore, as it was demonstrated that S. herbacea, methanol and ethanol extracts of fermented S. herbacea had no toxicity as materials of cosmetics and of the four specimens, ethanol extract of fermented S. herbacea has the highest in cytotoxicity, tyrosinase inhibitory effect and DPPH radical scavenging effect, its possibility to be used as a material of fermented cosmetics was confirmed.