소리쟁이 추출물을 이용한 멜라닌 생성억제와 피부의 멜라닌 · 홍반 값의 변화도
Melanin Inhibitory Activity and Changes in the Melanin and Erythema Values of Rumex crispus L. Extracts
2
조회
0
다운로드
16
인용
0
참고문헌
키워드
초록
By using the Rumex crispus L. root extract, the attempt is undertaken to measure the melanin inhibitory activity and change in the melanin and erythema values in a way of reviewing the function as the functional cosmetics composition. Rumex crispus L. root ethanol extract and tyrosinase inhibitory activity and cell viability in B16F10melanoma cells, melanin inhibitory activity and the essence and pack manufactured by applying to the melanin and erythema values were also studied. As a result, the inhibition of the tyrosinase was shown its effect at the density of 125 ㎍/㎖ of extracted material. For the B16F10 cell, the cell viability did not show the cytotoxicity at the density of 200 ㎍/㎖ or less and the tyrosinase activation control was shown to be 16.0% at 100 ㎍/㎖ while the melanin inhibitory activity was for 14.0%. The change of the melanin and erythema value of skin was shown to have the noticeable difference (p<.001) in the experiment group following the time of use for the index prior to experiment compared to the contrast group. According to the foregoing result, the extract from the Rumex crispus L. root showed skin whitening improvement effect to have the possibility as the ingredient for the functional cosmetics composition and it is considered to continue its studies on this subject.
Abstract
By using the Rumex crispus L. root extract, the attempt is undertaken to measure the melanin inhibitory activity and change in the melanin and erythema values in a way of reviewing the function as the functional cosmetics composition. Rumex crispus L. root ethanol extract and tyrosinase inhibitory activity and cell viability in B16F10melanoma cells, melanin inhibitory activity and the essence and pack manufactured by applying to the melanin and erythema values were also studied. As a result, the inhibition of the tyrosinase was shown its effect at the density of 125 ㎍/㎖ of extracted material. For the B16F10 cell, the cell viability did not show the cytotoxicity at the density of 200 ㎍/㎖ or less and the tyrosinase activation control was shown to be 16.0% at 100 ㎍/㎖ while the melanin inhibitory activity was for 14.0%. The change of the melanin and erythema value of skin was shown to have the noticeable difference (p<.001) in the experiment group following the time of use for the index prior to experiment compared to the contrast group. According to the foregoing result, the extract from the Rumex crispus L. root showed skin whitening improvement effect to have the possibility as the ingredient for the functional cosmetics composition and it is considered to continue its studies on this subject.
참고문헌 (26)
- 강민철, "제주도 자생 노루참나물 (Pimpinella komarovii) 추출물의 항산화 효과 및 멜라닌 억제 효과", KSBB Journal, 23(1), pp.77~82 (2008), 한국생물공학회
- 강상모, "국화류 추출물의 항산화 및 멜라닌 생성 억제 활성", Journal of the Korean Society for Applied Biological Chemistry, 51(4), pp.321~328 (2008), 한국응용생명화학회
- 고진아, "사람피부에 있어서 몇 가지 천연물의 미백 작용에 관한 연구", 석사, pp.2003
- 곽선순, "파동수를 이용한 피부미용 효과 연구", 대한피부미용학회지, 8(1), pp.75~86 (2010), 대한피부미용학회
- 전미선, "살구(Prunus armeniaca) 추출물의 생리활성에 관한 연구", 석사, 식품생명공학, pp.2006
- 도기승, "Broad band Ultraviolet A, Ultraviolet A-1, broad band Ultraviolet B,narrow band Ultraviolet B에 의한 최소 홍반량과 최소 색소량의 비교", 석사, pp.2003
- 리순화, "B16F10 mouse melanoma 세포주에서 백급에 의한 Tyrosinase 발현 및 멜라닌 생성 억제 효과", 한국두피모발미용학회지, 3, pp.5~20 (2007)
- 박수남, "식물유래 성분의 미백화장품(기능성화장품)에의 응용", 서울산업대학교 논문집, 52, pp.205~220 (2001)
- 박주아, "소리쟁이(Rumex crispus L.) 부위별 일반성분 및 이화학적 특성 분석", 대한피부미용학회지, 8(4), pp.193~202 (2010), 대한피부미용학회
- 백종현, "알부틴의 항멜라닌 효과", 대한피부과학회지, 38, pp.1303~1308 (2000)
- 성기천, "솔잎 추출물의 티로시나아제 활성억제 효과 및 분석", 韓國油化學會誌, 22(1), pp.71~76 (2005), 한국유화학회
- 양민진, "율피 추출물에 의한 Tyrosinase활성 억제 및 Melanin생성억제 효과", 한국환경 보건학회지, 25, pp.37~43 (1999)
- 이숙연, "소리쟁이 종자의 소염진통작용 및 간보호 효과", 생약학회지, 38(4), pp.334~338 (2007), 한국생약학회
- 이진영, "기능성 화장품 소재개발을 위한 in vitro 평가법", 동물실험대체법학회지, 1, pp.33~40 (2007)
- 정숙희, "Fucoidan의 멜라닌 합성과 tyrosinase 활성도 억제 효과", 생명과학회지, 19(1), pp.75~80 (2009), 한국생명과학회
- 진종언, "뽕나무(Morus alba L.)로부터 티로시나아제 프로모터 억제성분의 분석", 박사, pp.2002
- 한태진, "소리쟁이(Rumex cripus )의 부정근과모상근 배양에 의한 Anth raquinone 생산성", 식물생명공학회지, 26, pp.7~14 (1999)
- 허선정, "목단피 에탄올 추출물의 B16F10 멜라닌 생성 세포의 저해 작용과 항산화 활성", 대한피부미용학회지, 8(1), pp.1~9 (2010), 대한피부미용학회
- 황선우, "참소리쟁이 뿌리에서 안트라퀴논계 화합물의 분리 및 생리활성", Journal of the Korean Society for Applied Biological Chemistry, 47(2), pp.274~278 (2004), 한국응용생명화학회
- Boissy RE, "DeoxyArbutin: a novel reversible tyrosinase inhibitor with effective in vivo skin lightening potency", Exp. Dermatology, 14, pp.601~608 (2005)
- Briganti S, "Chemical and instrumental approaches to treat hyperpigmentation", Pigment cell Res, 16, pp.101~110 (2003)
- Hosoi J, "Regulation of melanin synthesis of B16 mouse melanoma cells by 1α, 25-Dihydroxyvitamin D3 and Retinoic Acid", Cancer Res, 45, pp.1474~1478 (1985)
- 정규영, "Screening extracts of Achyranthes japonica and Rumex crispus for activity against various plant pathogenic fungi and control of powdery mildew", PEST MANAGEMENT SCIENCE, 60, pp.803~808, JOHN WILEY & SONS LTD
- Park KH, "Inhibition kinetics of mushroom tyrosinase by copper-chelating ammonium tetrathiomolybdate", BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1726, pp.115~120 (2005), ELSEVIER SCIENCE BV
- Roberts SOB, "Pityrosporm orbiculate: incidence and distribution on clinically normal skin", Br. J. Dermatol, 81, pp.264~269 (1969)
- Yagi A, "The effect of tyrosinase inhibition for aloe", Planta Medica, 3981, pp.517~519 (1986)