도깨비 부채 뿌리 추출물의 피부 과다색소침착에 미치는 영향
Action of Rodgersia podophylla Root Extracts on Melanin Biosynthesis in Skin
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ABSTRACT : In the previous study, we reported the inhibitory effects of Rodgersia podophylla root extract on tyrosinase activity and melanin production in melan-a cells. However, mechanism of the inhibitory activity and in vivo assay were not yet examined. This study performed the examination of the effects of Rodgersia podophylla root extract on protein expression and in vivo depigmenting activity using melan-a cells and brown guinea pigs. As the results of western immunoblotting analysis, treatment of Rodgersia podophylla root extract reduced tyrosinase expression rates in 10 and 100 ppm concentrations, dose dependently. Moreover, Rodgersia podophylla root extract exhibited depigmenting activity on UV-B induced hyperpigmentation in brown guinea pig skin. These results suggested that Rodgersia podophylla root extract could act as whitening agent for the skin via not only direct tyrosinase activity inhibition but also reducing of tyrosinase expression.
Abstract
ABSTRACT : In the previous study, we reported the inhibitory effects of Rodgersia podophylla root extract on tyrosinase activity and melanin production in melan-a cells. However, mechanism of the inhibitory activity and in vivo assay were not yet examined. This study performed the examination of the effects of Rodgersia podophylla root extract on protein expression and in vivo depigmenting activity using melan-a cells and brown guinea pigs. As the results of western immunoblotting analysis, treatment of Rodgersia podophylla root extract reduced tyrosinase expression rates in 10 and 100 ppm concentrations, dose dependently. Moreover, Rodgersia podophylla root extract exhibited depigmenting activity on UV-B induced hyperpigmentation in brown guinea pig skin. These results suggested that Rodgersia podophylla root extract could act as whitening agent for the skin via not only direct tyrosinase activity inhibition but also reducing of tyrosinase expression.
참고문헌 (14)
- "Variation in melanin content and composition in type V and VI photoexposed and photoprotected human skin: the dominant role of DHI", 14, pp.337~347 (2001)
- "Linoleic acid and α-linolenic acid lightens ultraviolet-induced hyperpigmentation of the skin", 290, pp.375~381 (1998)
- "Melanin Biosynthesis Patterns following HormonalStimulation. J. Biol. Chem. 268", pp.25650~25655 (1993)
- "Keratinocytes growth factor promotes melanosome transfer to keratinocytes", 125, pp.1190~1199 (2005)
- "Four novel lignans from Rodgersia podophylla", 45, pp.339~341 (2004)
- "Hepatoprotective flavonol gylcosides from the aerial parts of Rodgersia podophylla", 70, pp.576~577 (2004)
- "Inhibitory effects of root extracts on melanin biosynthesis in rodgersia podophylla A. gray", 14(1), pp.27~30 (2006)
- "Inhibitory effects of ethanol extract of atractylodis rhizome alba on melanin biosynthesis", 45(3), pp.269~275 (2001)
- "Quantitative analysis of phenolic compounds in different parts of panax ginseng C.A. Meyer and its inhibitory effect on melanin biosynthesis", 14(3), pp.148~152 (2006)
- "Melanocyte biology and skin pigmentation", 445, pp.843~850 (2007)
- "Regulation of human skin pigmentation and responses to ultraviolet radiation", 20, pp.2~13 (2006)
- "Survey and mechanism of skin depigmenting and lightening agents", 20, pp.921~934 (2006)
- "Melanin pigmentation in mammalian skin and its hormonal regulation", 84, pp.1155~1228 (2004)
- "The biology of melanocytes", 14, pp.57~65 (2003)