Metformin HCl을 지속방출하는 하이드로겔 마이크로니들의 제조 및 평가
Manufacture and evaluation of hydrogel microneedles that continously releases metformin HCl
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
본 연구에서는 키토산과 PVA를 통해 메트포르민 HCl을 함유한 하이드로겔 마이크로니들을 제조하였다. 메트포르민 HCl은 경구 투여 시 위장관 장애를 유발하며 반감기가 짧아 1일 2~3번 복용 되어 환자의 복약 순응도가 낮다는 단점이 있다. 때문에 본 연구는 경구 투여 시 발생하는 위장관 장애를 최소화하고 환자의 복약 순응도를 높이기 위해 키토산과 PVA의 비율을 1:1, 1:2, 1:3으로 조절하여 약물을 24시간 지속 방출할 수 있는 하이드로겔 마이크로니들을 제조 및 평가하는 것을 목표로 하였다. 모든 비율에서 마이크로니들이 피부에 침투할 수 있는 적절한 강도와 유연성을 가지고 있음을 확인했으며, 24시간 동안 80% 이상의 약물 방출을 나타내었다. 그중 1:2 비율이 약물을 지속 방출하는 데 있어 최적의 비율임을 확인하였으며, 이를 통해 메트포르민 HCl 경구 투여시 발생하는 위장관 장애를 최소화하고 환자의 복약 순응도를 높일 수 있음을 기대할 수 있다.
Abstract
In this study, hydrogel microneedles containing metformin HCl were fabricated using chitosan and PVA. Metformin HCl causes gastrointestinal disorders when administered orally and has a short half-life, so it has the disadvantage of being taken 2-3 times a day, resulting in low patient compliance. Therefore, in order to minimize gastrointestinal disorders that occur during oral administration and increase patient compliance, this study adjusted the ratio of chitosan and PVA to 1:1, 1:2, and 1:3 to develop a drug that can continuously release the drug for 24 hours. The goal was to manufacture and evaluate hydrogel microneedles. It was confirmed that the microneedles had appropriate strength and flexibility to penetrate the skin at all ratios, and more than 80% of the drug was released over 24 hours. Among them, it was confirmed that the 1:2 ratio is the optimal ratio for sustained release of the drug, which can be expected to minimize gastrointestinal disorders that occur during oral administration of metformin HCl and increase patient compliance.
참고문헌 (9)
- Soo Hwan Lee, "Development and Evaluation of Implant using Hot-Melt Extrsion", Yakhak Hoeji, 67(1), pp.32~44 (2023)
- Andre J. Scheen, "Clinical Pharmacokinetics of Metformin", Clin Pharmacokinet, 30(5), pp.359~371 (1996)
- Suein Choi, "Population pharmacokinetic analysis of metformin administered as fixed-dose combination in Korean healthy adults", Transl Clin Pharmacol, 26(1), pp.25~31 (2018)
- Laura J. McCreight, "Metformin and the gastrointestinal tract", Diabetologia, 59(3), pp.426~435 (2016)
- RAVI TEJA ALLENA, "Preparation and evaluation of transdermal patches of metformin hydrochloride using natural polymer for sustained release", International Journal of Pharmacy and Pharmaceutical Sciences, 4, pp.297~302 (2012)
- Cameron Ryall, "Chitosan-based microneedle arrays for dermal delivery of Centella asiatica", International Journal of Pharmaceutics, 5, pp.627~ (2022)
- Joseph G. Turner, "Hydrogel-Forming Microneedles : Current Advancements and Future Trends", Macromolecula Bioscience, 21(2), pp.e2000307~ (2021)
- Hyun Sang Jang, "Characterization and Optimization of Hydrogel by Freezing-Thawing Method using Response Surface Methodology", The Korean Society for Biotechnology and Bioengineering, 34(3), pp.145~153 (2019)
- Rongyan He, "A Hydrogel Microneedle Patch for Point-of-Care Testing Based on Skin Interstitial Fluid", Adnaced Healthcare Materials, 9(4), pp.e1901201~ (2020)