감마선을 이용한 Metronidazole이 함유된 Poly(vinyl alcohol) 하이드로겔 제조 및 특성
Preparation and Characterization of Poly(vinyl alcohol) Hydrogel Contain Metronidazole by Irradiation
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초록
Periodontitis is disease of damaged gum tissue that is not removed the plaque ontoteeth. In case that the symptoms of disease get pain worse, it will have to extract tooth because oftumefy or bleeding at gums so treatment of drug was required to periodontitis. In this study, thehydrogel was prepared by including superior viscous, excellent elastic, and biocompatibility ofPoly(vinyl alcohol, PVA) and antimicrobial drug of Metronidazole (MD). The 15 wt% PVA wasdissolved in deionized water and then prepared PVA solution was irradiated using gamma-ray at25 kGy (10 kGy hr-1). In addition, PVA hydrogel was immersed in each 0.1, 0.25 and 0.5 wt% MDsolution using stirrer for 24 hr. The result of the gelation, 0.5 wt% MD loaded PVA hydrogel (76%)was lower than PVA hydrogel (88.2%). The swelling ration of 0.5 wt% MD loaded PVA hydrogel(294.8%) was higher than PVA hydrogel (105.2%). The compressive strength and thermal propertiesof MD loaded PVA hydrogel was gradually lower. The drug release test of 0.5 wt% MD loadedPVA hydrogel (61%) was higher than 0.1 wt% MD loaded PVA hydrogel (12%). Therefore, MDloaded PVA hygrogel may be a promising tool for periodontitis medicine by gamma-ray.
Abstract
Periodontitis is disease of damaged gum tissue that is not removed the plaque ontoteeth. In case that the symptoms of disease get pain worse, it will have to extract tooth because oftumefy or bleeding at gums so treatment of drug was required to periodontitis. In this study, thehydrogel was prepared by including superior viscous, excellent elastic, and biocompatibility ofPoly(vinyl alcohol, PVA) and antimicrobial drug of Metronidazole (MD). The 15 wt% PVA wasdissolved in deionized water and then prepared PVA solution was irradiated using gamma-ray at25 kGy (10 kGy hr-1). In addition, PVA hydrogel was immersed in each 0.1, 0.25 and 0.5 wt% MDsolution using stirrer for 24 hr. The result of the gelation, 0.5 wt% MD loaded PVA hydrogel (76%)was lower than PVA hydrogel (88.2%). The swelling ration of 0.5 wt% MD loaded PVA hydrogel(294.8%) was higher than PVA hydrogel (105.2%). The compressive strength and thermal propertiesof MD loaded PVA hydrogel was gradually lower. The drug release test of 0.5 wt% MD loadedPVA hydrogel (61%) was higher than 0.1 wt% MD loaded PVA hydrogel (12%). Therefore, MDloaded PVA hygrogel may be a promising tool for periodontitis medicine by gamma-ray.
참고문헌 (20)
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