Hyperpolarization: Sensitivity Boost in Magnetic Resonance Spectroscopy and Imaging
2
조회
0
다운로드
7
인용
0
참고문헌
키워드
초록
Hyperpolarization methods are the most emerging techniques in the field of magnetic resonance (MR) researches since they make a contribution to overcoming sensitivity limitation of MR spectroscopy and imaging, leading to new fields of researches, real-time in vivo metabolic/molecular imaging and MR analysis of chemical/biological reactions in non-equilibrium conditions. Make use of enormous signal enrichments, it becomes feasible to investigate various chemical and biochemical systems with low γ nuclei in real-time. This review deals with the theoretical principals of common hyperpolarization methods and their experimental features. In addition, more detailed theories, mechanisms, and applications of dissolution dynamic nuclear polarization (D-DNP) are discussed.
Abstract
Hyperpolarization methods are the most emerging techniques in the field of magnetic resonance (MR) researches since they make a contribution to overcoming sensitivity limitation of MR spectroscopy and imaging, leading to new fields of researches, real-time in vivo metabolic/molecular imaging and MR analysis of chemical/biological reactions in non-equilibrium conditions. Make use of enormous signal enrichments, it becomes feasible to investigate various chemical and biochemical systems with low γ nuclei in real-time. This review deals with the theoretical principals of common hyperpolarization methods and their experimental features. In addition, more detailed theories, mechanisms, and applications of dissolution dynamic nuclear polarization (D-DNP) are discussed.
참고문헌 (25)
- J. Cavanagh, "Protein NMR Spectroscopy: Principles And Practice" (1996), Academic Press, Inc.
- 김낙균, "NMR methods for structural analysis of RNA: a Review", Journal of the Korean Magnetic Resonance Society, 18(1), pp.5~9 (2014), 한국자기공명학회[DOI]
- 서정용, "NMR Studies on Transient Protein Complexes: Perspectives", Journal of the Korean Magnetic Resonance Society, 18(1), pp.1~4 (2014), 한국자기공명학회[DOI]
- C. R. Bowers, , Phys. Rev. Lett, 57, pp.2645~ (1986)
- C. R. Bowers, , J. Am. Chem. Soc, 109, pp.5541~ (1987)
- M. G. Pravica, , Chem. Phys. Lett, 145, pp.255~ (1988)
- R. W. Adams, , Science, 323, pp.1708~ (2009)
- A. S. Barton, , Phys. Rev. A, 49, pp.2766~ (1994)
- G. Navon, , Science, 271, pp.1848~ (1996)
- G. L. Closs, , J. Am. Chem. Soc, 91, pp.4552~ (1969)
- R. Kaptein, , Chem. Phys. Lett, 4, pp.195~ (1969)
- W. Müller-warmuth, , Adv. Magn. Reson, 11, pp.1~ (1983)
- K. Münnemann, , Appl. Magn. Reson, 34, pp.321~ (2008)
- M. Reese, , J. Am. Chem. Soc, 131, pp.15086~ (2009)
- E. R. McCarney, , Proc. Natl. Acad. Sci. U. S. A, 104, pp.1754~ (2007)
- D. A. Hall, , Science, 276, pp.930~ (1997)
- M. Goldman, "Spin temperature and nuclear magnetic resonance in solids" (1970), Clarendon Press Oxford
- J. H. Ardenkjaer-Larsen, , Proc. Natl. Acad. Sci. U. S. A, 100, pp.10158~ (2003)
- K. Golman, , Proc. Natl. Acad. Sci. U. S. A, 100, pp.10435~ (2003)
- K. Golman, , Cancer Res, 66, pp.10855~ (2006)
- S. Hu, , Magn. Reson. Imaging, 30, pp.1367~ (2012)
- G. D. Reed, , J. Magn. Reson, 217, pp.41~ (2012)
- S. J. Nelson, , Sci. Transl. Med, 5, pp.198~ (2013)
- S. Bowen, , Angew. Chem. Int. Ed, 47, pp.5235~ (2008)
- Y. Lee, , J. Am. Chem. Soc, 135, pp.4636~ (2013)