The ALTADENA and PASADENA studies in benchtop NMR spectrometer
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Parahydrogen induced hyperpolarization (PHIP) technique is extensively studied to increase the sensitivity of the conventional NMR spectroscopy and recently try to apply this advanced technique into the revolutionary future of the MRI. The other hyperpolarization technique, which is widely utilized, is DNP (Dynamic Nuclear Polarization)-based hyperpolarization one. Despite its great advances in these fields, it contains several drawbacks to overcome: fast relaxation time, expensive equipment is needed, long build-up time is required (several hours), and batch scale material is hyperpolarized. To overcome all those limitations, one can effectively harness the hyperpolarized spin state of parahydrogen. One important step for utilizing the spin state of parahydrogen is doing well-developed experiments of ALTADENA and PASADENA. Based on those concepts, we successfully obtain the hydrogenation signals of ALTADENA and PASADENA from styrene by using benchtop NMR spectrometer. Also those signals were conceptually analyzed and confirmed with different mechanisms. To our best knowledge, those experiments using 1.4T (benchtop NMR) is the first reported one. Considering these experiments, we hope that parahydrogen-based hyperpolarization transfer studies in NMR/MRI will be broadened in Korea in the future.
Abstract
Parahydrogen induced hyperpolarization (PHIP) technique is extensively studied to increase the sensitivity of the conventional NMR spectroscopy and recently try to apply this advanced technique into the revolutionary future of the MRI. The other hyperpolarization technique, which is widely utilized, is DNP (Dynamic Nuclear Polarization)-based hyperpolarization one. Despite its great advances in these fields, it contains several drawbacks to overcome: fast relaxation time, expensive equipment is needed, long build-up time is required (several hours), and batch scale material is hyperpolarized. To overcome all those limitations, one can effectively harness the hyperpolarized spin state of parahydrogen. One important step for utilizing the spin state of parahydrogen is doing well-developed experiments of ALTADENA and PASADENA. Based on those concepts, we successfully obtain the hydrogenation signals of ALTADENA and PASADENA from styrene by using benchtop NMR spectrometer. Also those signals were conceptually analyzed and confirmed with different mechanisms. To our best knowledge, those experiments using 1.4T (benchtop NMR) is the first reported one. Considering these experiments, we hope that parahydrogen-based hyperpolarization transfer studies in NMR/MRI will be broadened in Korea in the future.
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