알츠하이머와 혈관성 치매 환자 선별에서의 작업기억 능력 관련 구어유창성 및 이야기이해 능력의 차이
Differences in Verbal Fluencies and Discourse Comprehension Abilities associated with Working Memory in Alzheimer’s Disease and Vascular Dementia
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초록
본 연구는 알츠하이머와 혈관성 치매 환자를 대상으로 구어유창성과 이야기이해 과제 수행능력의 차이 및 작업기억 처리수준과의 상관 그리고 언어능력 관련 요인선별을 위해 시행되었다. 전반적인 인지능력에서 차이를 보이지 않는 각기 15명의 환자를 대상으로 구어유창성 내 음소유창성 및 이야기이해 그리고 작업기억 하위과제인 지연회상과 재인과제에서 두 그룹 간 유의한 수행능력의 차이를 보였다. 상관 및 회귀분석에서는 알츠하이머 그룹이 작업기억 내 역행 숫자기억 과제와 이야기이해 과제에서만 유의한 상관을 보인 반면, 혈관성 치매 그룹은 추가적으로 재인 점수에서도 이야기이해 능력과의 유의한 상관이 나타났다. 한편, 회귀분석에서는 혈관성 치매 그룹에서만 언어적 작업기억 능력이 이야기이해 능력의 예측 요인임을 확인하였다. 결론적으로 두 유형의 치매를 구분하는 데 있어 음소유창성 과제 외에 이야기이해 및 작업기억 과제가 유의한 도구임이 확인되었는데, 이를 통해 두 유형의 치매에 대한 분류기준을 제고함은 물론 적절한 치료계획 및 효율적인 중재에 부가적인 기여를 할 것으로 보인다.
Abstract
The present study was conducted to examine the differences and correlations between verbal fluency and story comprehension according to the working memory(WM) capacity, and to find out what WM factors influence the linguistic competence in Alzheimer's disease(AD) and vascular dementia(VaD) groups each consisting of 15 patients. The results of their performance produced firstly significant differences in phonemic fluency, story comprehension, delayed recall and recognition task between the two groups. Further analysis shows that VaD group had significant correlations between the scores of story comprehension and the recognition test scores additionally. These findings suggest that it is possible to differentiate the two groups even by story comprehension tasks and WM. In conclusion, the clinical application of the results is likely to contribute to appropriate treatment plans and effective interventions for elderly with AD and VaD as well as to improve the classification criteria for both types of dementia.
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