혈청지질분포와 치주질환간의 연관성에 관한 융합연구
The Association Between Serum Lipid profiles and periodontitis on Convergence
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
본 연구의 목적은 우리나라 30세이상 성인의 혈청지질분포와 치주질환간의 관련성을 파악하고자 하였다. 본 연구 자료는 2013년, 2014년 국민건강영양조사 자료를 병합하여 이용하였으며, 최종분석대상자는 8,854명이었다. 치주질환은 지역사회치주지수를 이용하였으며, 혈청지질분포와 치주질환간의 관련성을 파악하기 위해 로지스틱회귀분석을 이용하였다. 연구결과 HDL 이 ≤40mg/dL 인 경우에서 치주질환 교차비가 1.39배(95% CI=1.16-1.66)증가하였으며, Triglyceride가 ≥200 mg/dL 인 경우에서 치주질환 교차비가 1.14배(95% CI=1.02-1.27) 유의하게 증가하였다. HDL과 Triglyceride가 치주질환과 유의한 관련성이 있음을 확인하였다. 따라서, 향후 연구에서는 혈청지질분포와 치주질환간의 실질적 관련성을 파악하고 인과관계와 직접적인 연관성을 파악해야 할 것이다
Abstract
The aim of this study was to evaluate the association between Lipid profiles and periodontal diseases in Korea adults. The date from the 2013, 2014 Korean National Health and Nutrition Survey were used, and 8,854 subjects over 30 years were included in the analysis. periodontal disease was assessed using the Community periodontal Index. Study participants with HDL between ≤40mg/dL(high) were 1.39 times(95% CI=1.16 to 1.66) as likely to have periodontal disease as those with normal levels and those with Triglyceride ≥200mg/dL(high) were 1.14 times(95% CI=1.02 to 1.27) as likely to have periodontal disease as those with normal levels. positive significant association was observed between serum lipid profiles and periodontal disease; however, further studies need to be conducted to understand the actual relationship between STC levels and periodontitis and to establish causality and directional association.
참고문헌 (28)
- A. C. E. Leite, "Effects of periodontal therapy on C-reactive protein and HDL in serum of subjects with periodontitis", Brazilian Journal of Cardiovascular Surgery, 29(1), pp.69~77 (2014)
- D. Kinane., "periodontal diseases' contributions to cardiovascular disease : an overview of potential mechanisms", Annals of periodontology, 3(1), pp.142~150 (1998)[DOI]
- Ö Fentoğlu, "Proinflammatory cytokine levels in hyperlipidemic patients with periodontitis after periodontal treatment", Oral Diseases, 18(3), pp.299~306 (2012), Wiley[DOI]
- 원영순, "성인의 흡연상태와 치주질환의 관련성: 2012년 국민건강영양조사 자료를 기반으로", 대한구강보건학회지, 40(2), pp.133~139 (2016), 대한예방치과·구강보건학회
- 김지현, "비만과 치주질환간의 관련성에 관한 융합연구", 한국융합학회논문지, 9(8), pp.71~76 (2018), 한국융합학회[DOI]
- Bruce L Pihlstrom, "Periodontal diseases", The Lancet, 366(9499), pp.1809~1820 (2005), Elsevier BV[DOI]
- Tuomas Saxlin, "Association between serum lipid levels and periodontal infection", Journal of Clinical Periodontology, 35(12), pp.1040~1047 (2008), Wiley[DOI]
- B. J. Goldman, "Cecil Textbook of Medicine" (2000), WB Saunders
- Joseph Katz, "On the association between hypercholesterolemia, cardiovascular disease and severe periodontal disease", Journal of Clinical Periodontology, 28(9), pp.865~868 (2001), Wiley[DOI]
- Satu Korhonen, "Serum cholesterol ratios and periodontal infection: results of the Health 2000 Survey", Journal of Clinical Periodontology, 38(9), pp.787~794 (2011), Wiley[DOI]
- Wolfgang Losche, "Plasma lipid and blood glucose levels in patients with destructive periodontal disease", Journal of Clinical Periodontology, 27(8), pp.537~541 (2000), Wiley[DOI]
- W. Losche, "Lipoprotein-associated phospholipase A2 and plasma lipids in patients with destructive periodontal disease", Journal of Clinical Periodontology, 32(6), pp.640~644 (2005), Wiley[DOI]
- Pirkko J. Pussinen, "Severe Periodontitis Enhances Macrophage Activation via Increased Serum Lipopolysaccharide", Arteriosclerosis, Thrombosis, and Vascular Biology, 24(11), pp.2174~2180 (2004), Ovid Technologies (Wolters Kluwer Health)[DOI]
- Susan Thapa, "Association Between High Serum Total Cholesterol and Periodontitis: National Health and Nutrition Examination Survey 2011 to 2012 Study of American Adults", Journal of Periodontology, 87(11), pp.1286~1294 (2016), Wiley[DOI]
- K Buhlin, "Risk factors for cardiovascular disease in patients with periodontitis", European Heart Journal, 24(23), pp.2099~2107 (2003), Oxford University Press (OUP)[DOI]
- A. C. Machado, "Relation between chronic periodontal disease and plasmatic levels of triglycerides, total cholesterol and fractions", Brazilian oral research, 19(4), pp.284~289 (2005)
- "Oral Health Surveys: Basic Methods. World Health Organization" (1995)[URL]
- Committee for Guidelines for Management of Dyslipidemia, "2015 Korean Guidelines for Management of Dyslipidemia", Committee for Guidelines for Management of Dyslipidemia, 2287~2892 (2015)
- 김현덕, "심혈관계관련질환이 치주조직병에 미치는 영향", 대한구강보건학회지, 30(1), pp.46~55 (2006), 대한예방치과·구강보건학회
- 강현주, "대사증후군 환자의 치주질환과 치아상실에 관한 연구", 치위생과학회지, 15(4), pp.445~456 (2015), 한국치위생과학회
- A. Y. Ahn., "The effects of atherosclerosis on periodontal disease and decision making model", Master’s, pp.2015
- V. Kalburgi, "Warad. Saliva as a surrogate to explore the association between lipid profiles and chronic periodontitis: A case-control study", Dental research journal, 11(6), pp.619~623 (2014)
- S. A. Banihashemrad, "Relationship between cholesterol and triglyceride blood values and periodontal parameters in patients of Mashhad health center", The New York state dental journal, 74(5), pp.65~66 (2008)
- Joseph Katz, "Association Between Periodontal Pockets and Elevated Cholesterol and Low Density Lipoprotein Cholesterol Levels", Journal of Periodontology, 73(5), pp.494~500 (2002), Wiley[DOI]
- J. Hamissi, "A Comparison of Serum Lipid profile between periodontitis patients and Healthy Individuals", Iranian Red Crescent Medical Journal, 13(4), pp.283~284 (2011)
- A. Moeintaghavi, "Hyperlipidemia in patients with periodontitis", Journal of Contemporary Fental Practice, 6(3), pp.78~85 (2005)
- L. G. Hagh, "The association between hyperlipidemia and periodontal infection", Iranian Red Crescent Medical Journal, 16(12), pp.e6577~ (2014)[DOI]
- E. J. Marjanovic, "Do patients with osteoporosis have an increased prevalence of periodontal disease? A cross-sectional study", Osteoporosis international, 24(7), pp.1973~1979 (2013)[DOI]