Difference in Lung Functions according to Genetic Polymorphism of Tobacco Substance Metabolizing Enzymes of Korean Smokers
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This study aimed to determine whether there was a difference in lung functions of smokers according to the presence of carcinogenic genetic-metabolizing enzymes by comparing the results of lung functions and the presence of genetic metabolizing enzymes that metabolize tobacco substances. To achieve this, 31 smokers without no illness and no psychiatric history were selected (28 males and 3 females); they were aged 20 to 27 years and were physically and mentally healthy students attending K University. Their lung functions were measured, and gene polymorphisms of cytochrome P-450 1A1 (CYP1A1) related to metabolic activation of tobacco components and gene polymorphism of tumor protein 53 (TP53) related to lung cancer were analyzed. As a result, the mean values of lung function of TT and Arg / Arg without genetic mutations were the highest, and ANOVA analysis of CYP1A1 and lung functions showed that the P-value of FVC was 0.049, which was different between groups. In other words, there is no high mutation in Cytochrome P-450 1A1 (CYP1A1) gene, which is associated with the metabolic activation of tobacco components. In other words, In the absence of the mutant Cytochrome P-450 1A1 (CYP1A1) gene, which is associated with the metabolic activation of tobacco components, the value of FVC was high.
Abstract
This study aimed to determine whether there was a difference in lung functions of smokers according to the presence of carcinogenic genetic-metabolizing enzymes by comparing the results of lung functions and the presence of genetic metabolizing enzymes that metabolize tobacco substances. To achieve this, 31 smokers without no illness and no psychiatric history were selected (28 males and 3 females); they were aged 20 to 27 years and were physically and mentally healthy students attending K University. Their lung functions were measured, and gene polymorphisms of cytochrome P-450 1A1 (CYP1A1) related to metabolic activation of tobacco components and gene polymorphism of tumor protein 53 (TP53) related to lung cancer were analyzed. As a result, the mean values of lung function of TT and Arg / Arg without genetic mutations were the highest, and ANOVA analysis of CYP1A1 and lung functions showed that the P-value of FVC was 0.049, which was different between groups. In other words, there is no high mutation in Cytochrome P-450 1A1 (CYP1A1) gene, which is associated with the metabolic activation of tobacco components. In other words, In the absence of the mutant Cytochrome P-450 1A1 (CYP1A1) gene, which is associated with the metabolic activation of tobacco components, the value of FVC was high.
참고문헌 (22)
- WHO report on the global tobacco epidemic, 2017 :monitoring tobacco use and prevention policies, "World Health Organization", World Health Organization, ~ (2017)
- S. H. Jee, "Smoking-attributable mortality among Korean adults: 1981-2003", Korean Journal of Epidemiology, 28(1), pp.92~99 (2006)
- 정금지, "한국인 성인 남녀의 흡연관련 사망에 관한 연구", 보건정보통계학회지, 38(2), pp.36~48 (2013), 한국보건정보통계학회
- A. Hackshaw, "Low cigarette consumption and risk of coronary heart disease and stroke : meta-analysis of 141 cohort", British Medical Association, 360, pp.j5855~ (2018)[DOI]
- J. A. Miller, "Monograghs on the evaluation of the carcinogenic risk of chemicals to humans", International Agency For Research On Cancer, 38, pp.375~383 (1986)
- T. W. Kim, "Effet of smoking on Pulmonary Funcion In Ault Man", The Journal of Physical Education, 24, pp.317~329 (1996)
- R. N. Proctor, "The history of the discovery of the cigarette-lung cancer link : evidentiary traditions, corporate denial, global toll", Tobacco Control, 21(2), pp.87~91 (2012)[DOI]
- P. Lichtenstein, "Environmental and heritable factors in the causation of cancer-analyses of cohorts of twins from Sweden, Denmark, and Finland", New England journal of medicine, 343(2), pp.78~85 (2000)
- R. B. Bridges, "Effect of cigarette smoke fractions on the chemotaxis of polymorphonuclear leukocytes", Journal of Leukocyte Biology, 40(1), pp.73~85 (1986)[DOI]
- R. Bouclin, "The effects of smoking on periodontal structures", Canadian Dental Association, 63(5), pp.356~363 (1997)
- J. R. McGuire, "Cotinine in saliva and gingival crevicular fluid of smokers with periodontal disease", Journal of Periodontology, 60(4), pp.176~181 (1989)[DOI]
- 이명효, "목 안정화와 호흡 재교육 운동이 만성 뇌졸중 환자의 목 깊은 굽힘근육의 두께, 노력성 폐활량과 최대 기침 유량에 미치는 효과", 한국전문물리치료학회지, 22(1), pp.19~29 (2015), 한국전문물리치료학회[DOI]
- 이국행, "Cytochrome P450 1A1(CYP1A1)과 Glutathione S-Transferase P1(GSTP1) 유전자 다형성이 후두암 발생에 미치는 영향", 대한이비인후-두경부외과학회지, 45(1), pp.56~61 (2002), 대한이비인후과학회
- M. Oliver, "TP53mutations in human cancers: origins, consequences, and clinical use", Cold Spring Harbor Perspectives in Biology, 2(1), pp.a001008~ (2010)[DOI]
- 정상봉, "한국인의 폐암에서 TP53 유전자 변이 분석", Laboratory Medicine Online, 1(4), pp.202~208 (2011), 대한진단검사의학회
- 구진숙, "호기 중 일산화탄소 농도에 따른 양도락 상의 변화 연구(후향적 증례연구)", 대한한의학회지, 41(1), pp.45~54 (2020), 대한한의학회[DOI]
- Y. J. Hwan, "A Comparison of Pulmonary Function between Smoker and Non-smoker Focusing on the Body Surface Area", Journal of Sport and Leisure Studies, 14(11), pp.659~666 (2000)
- F. J. Gonzalez, "Role of Human cytochromes P450 in the metabolic activation of chemical carcinogens and toxins", Drug Metabolism Reviews, 26(1), pp.165~171 (1994)[DOI]
- L. Mao, "Recent advances in the molecular diagnosis of lung cancer", Oncogene, 21, pp.6960~6969 (2002)
- B. Vogelstein, "Surfing the p53 network", Nature, 408, pp.307~310 (2000)
- H. J. Cohen, "Biology of aging as related to cancer", Cancer, 74, pp.2092~2100 (1994)[DOI]
- E. Hallier, "A note on individual differences in the urinary excretion of opical enantiomers of styrene metabolites and of styrene-derived metcapturic acids in humans", Archives of toxicology, 69(5), pp.300~305 (1995)[DOI]