Relationship of Vitamin D Binding Protein Polymorphisms and Lung Function in Korean Chronic Obstructive Pulmonary Disease
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Purpose: Multiple genetic factors are associated with chronic obstructive pulmonarydisease (COPD). The association of gene encoding vitamin D binding protein (VDBP, GC) with COPD has been controversial. We sought to investigate the types of GC variants in the Korean population and determine the association of GC variants with COPD and lung function in the Korean population. Materials and Methods: The study cohort consisted of 203 COPD patients and 157 control subjects. GC variants were genotyped by the restriction fragment-length polymorphismmethod. Repeated measures of lung function data were analyzed using a linear mixed model including sex, age, height, and pack-years of smoking to investigatethe association of GC genetic factors and lung function. Results: GC1F variant was most frequently observed in COPD (46.1%) and controls (42.0%). GC1S variant (29.0% vs. 21.4%; p=0.020) and genotype 1S-1S (8.3% vs. 3.4%; p=0.047) were more commonly detected in control than COPD. According to linearmixed model analysis including controls and COPD, subjects with genotype 1S-1S had 0.427 L higher forced expiratory volume in 1 second (FEV1) than those with other genotypes (p=0.029). However, interaction between the genotype and smoking pack-year was found to be particularly significant among subjects with genotype 1S-1S; FEV1 decreased by 0.014 L per smoking pack-year (p=0.001). Conclusion: This study suggested that GC polymorphism might be associated with lung function and risk of COPD in Korean population. GC1S variant and genotype 1S-1S were more frequently observed in control than in COPD. Moreover,GC1S variant was more common in non-decliners than in rapid decliners among COPD.
Abstract
Purpose: Multiple genetic factors are associated with chronic obstructive pulmonarydisease (COPD). The association of gene encoding vitamin D binding protein (VDBP, GC) with COPD has been controversial. We sought to investigate the types of GC variants in the Korean population and determine the association of GC variants with COPD and lung function in the Korean population. Materials and Methods: The study cohort consisted of 203 COPD patients and 157 control subjects. GC variants were genotyped by the restriction fragment-length polymorphismmethod. Repeated measures of lung function data were analyzed using a linear mixed model including sex, age, height, and pack-years of smoking to investigatethe association of GC genetic factors and lung function. Results: GC1F variant was most frequently observed in COPD (46.1%) and controls (42.0%). GC1S variant (29.0% vs. 21.4%; p=0.020) and genotype 1S-1S (8.3% vs. 3.4%; p=0.047) were more commonly detected in control than COPD. According to linearmixed model analysis including controls and COPD, subjects with genotype 1S-1S had 0.427 L higher forced expiratory volume in 1 second (FEV1) than those with other genotypes (p=0.029). However, interaction between the genotype and smoking pack-year was found to be particularly significant among subjects with genotype 1S-1S; FEV1 decreased by 0.014 L per smoking pack-year (p=0.001). Conclusion: This study suggested that GC polymorphism might be associated with lung function and risk of COPD in Korean population. GC1S variant and genotype 1S-1S were more frequently observed in control than in COPD. Moreover,GC1S variant was more common in non-decliners than in rapid decliners among COPD.
참고문헌 (36)
- Snider GL, "Chronic obstructive pulmonary disease: risk factors, pathophysiology and pathogenesis", Annu Rev Med, 40, pp.411~429 (1989)
- Behrendt CE, "Mild and moderate-to-severe COPD in nonsmokers: distinct demographic profiles", Chest, 128, pp.1239~1244 (2005)
- Bridevaux PO, "Prevalence of airflow obstruction in smokers and never-smokers in Switzerland", Eur Respir J, 36, pp.1259~1269 (2010)
- Fletcher C, "The natural history of chronic airflow obstruction", Br Med, 1, pp.1645~1648 (1977)
- Kim DS, "Prevalence of chronic obstructive pulmonary disease in Korea: a population-based spirometry survey", Am J Respir Crit Care Med, 172, pp.842~847 (2005)
- Lamprecht B, "COPD in never smokers: results from the population-based burden of obstructive lung disease study", Chest, 139, pp.752~763 (2011)
- Khoury MJ, "Genetic-environmental interactions in chronic airways obstruction", Int J Epidemiol, 15, pp.65~72 (1986)
- Tager I, "Studies of the familial aggregation of chronic bronchitis and obstructive airways disease", Int J Epidemiol, 7, pp.55~62 (1978)
- Hersh CP, "Attempted replication of reported chronic obstructive pulmonary disease candidate gene associations", Am J Respir Cell Mol Biol, 33, pp.71~78 (2005)
- Hirschfeld J, "Immune-electrophoretic demonstration of qualitative differences in human sera and their relation to the haptoglobins", Acta Pathol Microbiol Scand, 47, pp.160~168 (1959)
- Daiger SP, "Group-specific component (Gc) proteins bind vitamin D and 25-hydroxyvitamin D", Proc Natl Acad Sci U S A, 72, pp.2076~2080 (1975)
- Binder R, "Neutrophil priming by cytokines and vitamin D binding protein (Gc-globulin): impact on C5a-mediated chemotaxis, degranulation and respiratory burst", Mol Immunol, 36, pp.885~892 (1999)
- Kew RR, "Localization and quantitation of the vitamin D binding protein (Gc-globulin) in human neutrophils", Blood, 82, pp.274~283 (1993)
- Piquette CA, "Human monocyte chemotaxis to complement-derived chemotaxins is enhanced by Gc-globulin", J Leukoc Biol, 55, pp.349~354 (1994)
- Yamamoto N, "Vitamin D3 binding protein (group-specific component) is a precursor for the macrophage-activating signal factor from lysophosphatidylcholine-treated lymphocytes", Proc Natl Acad Sci U S A, 88, pp.8539~8543 (1991)
- Cooke NE, "Direct regional assignment of the gene for vitamin D binding protein (Gc-globulin) to human chromosome 4q11-q13 and identification of an associated DNA polymorphism", Hum Genet, 73, pp.225~229 (1986)
- Cleve H, "The mutants of the vitamin-D-binding protein: more than 120 variants of the GC", DBP system, 1988, pp.54, 215~225
- Horne SL, "Possible protective effect against chronic obstructive airways disease by the GC2 allele", Hum Hered, 40, pp.173~176 (1990)
- Ishii T, "Association of Gc-globulin variation with susceptibility to COPD and diffuse panbronchiolitis", Eur Respir J, 18, pp.753~757 (2001)
- Ito I, "Risk and severity of COPD is associated with the group-specific component of serum globulin 1F allele", Chest, 125, pp.63~70 (2004)
- Korytina GF, "Genotypes of vitamin-D-binding protein (DBP) in patients with chronic obstructive pulmonary disease and healthy population of Republic Bashkortostan", Mol Biol (Mosk), 40, pp.231~238 (2006)
- Laufs J, "Association of vitamin D binding protein variants with chronic mucus hypersecretion in Iceland", Am J Pharmacogenomics, 4, pp.63~68 (2004)
- Lu M, "The relationship between vitamin D binding protein gene polymorphism and chronic obstructive pulmonary disease", Zhonghua Nei Ke Za Zhi, 43, pp.117~120 (2004)
- Sandford AJ, "Susceptibility genes for rapid decline of lung function in the lung health study", Am J Respir Crit Care Med, 163, pp.469~473 (2001)
- Schellenberg D, "Vitamin D binding protein variants and the risk of COPD", Am J Respir Crit Care Med, 157(3 Pt 1), pp.957~961 (1998)
- Bakke PS, "Candidate genes for COPD in two large data sets", Eur Respir J, 37, pp.255~263 (2011)
- Chishimba L, "The vitamin D axis in the lung: a key role for vitamin D-binding protein", Thorax, 65, pp.456~462 (2010)
- "Global strategy for the diagnosis management, and prevention of chronic obstructive pulmonary disease" (2011)[URL]
- Neyman J, "On the problem of the most efficient tests of statistical hypotheses", Philos Trans R Soc Lond, 231, pp.289~337 (1933)
- Harville DA, "Maximum likelihood approaches to variance component estimation and to related problems", J Am Stat Assoc, 72, pp.320~338 (1977)
- Kueppers F, "Familial prevalence of chronic obstructive pulmonary disease in a matched pair study", Am J Med, 63, pp.336~342 (1977)
- Kauffmann F, "Genetic markers in chronic air-flow limitation. A genetic epidemiologic study", Am Rev Respir Dis, 127, pp.263~269 (1983)
- Janssens W, "Vitamin D deficiency is highly prevalent in COPD and correlates with variants in the vitamin D-binding gene", Thorax, 65, pp.215~220 (2010)
- Gomme PT, "Therapeutic potential of vitamin D-binding protein", Trends Biotechnol, 22, pp.340~345 (2004)
- Wood AM, "Vitamin D-binding protein contributes to COPD by activation of alveolar macrophages", Thorax, 66, pp.205~210 (2011)
- Kasuga I, "Lack of association of group specific component haplotypes with lung function in smokers", Thorax, 58, pp.790~793