듀얼 FDG 자동합성장치 개발
Development of Dual FDG Auto Synthesis Module
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초록
[18F]FDG (2-[18F] Fluoro-2-deoxy-D-Glucose), which is required Automated SyntheticModule for production, is most often used Radiopharmaceuticals in nuclear medicine. In this study,an Automated Synthesis Module was developed to produce FDG in two consecutive time when F-18 feds continuously by modifying a domestic FDG Automated Synthetic Module on structuralgeometry and control system. The results were showed that the Average Synthesis Yields on thedeveloped Automated Synthetic Module were 45±3% (n=20), 50±3% (n=20) respectively. TheQuality Control results, such as Radio TLC, Radiochemical purity, Gamma-counter, pH, LALTest, Micro bacteria test, showed in same level with domestic [18F]FDG Auto-Synthetic modules. Therefore, if some features were improved by considering the components life time and appearance,commercial sales can be expected because of low price and easy maintenance comparedwith foreign products.
Abstract
[18F]FDG (2-[18F] Fluoro-2-deoxy-D-Glucose), which is required Automated SyntheticModule for production, is most often used Radiopharmaceuticals in nuclear medicine. In this study,an Automated Synthesis Module was developed to produce FDG in two consecutive time when F-18 feds continuously by modifying a domestic FDG Automated Synthetic Module on structuralgeometry and control system. The results were showed that the Average Synthesis Yields on thedeveloped Automated Synthetic Module were 45±3% (n=20), 50±3% (n=20) respectively. TheQuality Control results, such as Radio TLC, Radiochemical purity, Gamma-counter, pH, LALTest, Micro bacteria test, showed in same level with domestic [18F]FDG Auto-Synthetic modules. Therefore, if some features were improved by considering the components life time and appearance,commercial sales can be expected because of low price and easy maintenance comparedwith foreign products.
참고문헌 (2)
- 박준형, "국산18F-FDG Auto Synthesizer의 수율 향상과 성능개선", 대한핵의학기술학회, 13(3), pp.147~151 (2009)
- FDG production module, "Nucl. Instr. and Meth. in Phys. Res. B", 2007, 816~818