방사성 의약품 자동 분주장치의 유용성 및 최적화된 분주 방법 평가

Abstract

Recently, there is an increase of the number of hospitals using auto dispenser to reduce occupational radiation exposure when drawing up of the 18F-FDG dose (5.18 MBq/kg) in a syringe from the dramatic high activity of 18F-FDG multidose vial. The aim of this study is to confirm that using auto dispenser actually reduces the radiation exposure for technologists. Also we analyzed the reproducibility of auto dispenser to find optimized dispensing method for the device. We conducted three experiments. ① Comparison of radiation exposure on chest and hands: The chest and hands exposure dose received by technologists during the injection were measured by electronic personal dosimeter(EPD) and ring TLD respectively. ② Reproducibility of dispensed volume: We draw up the normal saline into 5 and 2 mL syringe using auto dispenser by changing the volume from 1 to 15 mm for 5 times in the same setting of the volume. The weight of 5 normal saline dispensed from the device at same volume was measured using micro balance and calculated standard deviation and coefficient of variation. ③Reproducibility of dispensed radioactivity: We dispensed 362.6 MBq ± 10% of 18F-FDG in 5 and 2 mL syringes from the multidose vial of different specific activity. In the same setting of volume, we repeated dispensing for 4 times and compared standard deviation and coefficient of variation of radioactivity between 5 syringes. There was significant difference in the average of chest exposure dose according to the dispensing methods(p < 0.05). Also, when dispensing 18F-FDG in manual method, exposure dose was 11.5 times higher in right hand and 4.8 times higher in left hand than in auto method. In the result of reproducibility of dispensed volume, standard deviation and coefficient of variation shows decline as the dispensing volume increases. As a result of reproducibility of dispensed radioactivity, standard deviation and coefficient of variation increases as the specific activity increases. We approved that the occupational radiation exposure dose of technologists were reduced when dispensing 18F-FDG using auto dose dispenser. Secondly, using small syringes helps to increase reproducibility of auto dose dispense. And also, if you lower the specific activity of 18F-FDG in multidose vial below 915-1020 MBq/mL, you can use auto dispenser more effectively keeping the coefficient of variation lower than 10%.