조선대학교 사이클로트론 시설의 RI 배기필터 성능평가 및 18F 배출저감 연구
Performance of the RI Exhaust Filter at Chosun University Cyclotron Facility and 18F Emission Reduction
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Recently, the number of PET cyclotrons has increased in Korea. A cyclotron mainly produces 18F, which is used for the production of [18F]FDG, a cancer diagnostic radiopharmaceutical. For radiation protection, the discharge control standard under the Nuclear Safety Act limits the radioactive concentration of 18F in the exhaust discharged from a nuclear power utilization facility to below 2,000 Bq m-3. However, the radioactive concentration of 18F discharged during [18F]FDG production at the cyclotron facility at Chosun University is maintained at about 1,500 Bq m-3 on average, which is 75% of the concentration limit of the discharge control standard, and temporarily exceeds the standard as per the real-time monitoring results. This study evaluated the performance of the exhaust filter unit of the cyclotron facility at Chosun University by assessing the concentration of 18F in the exhaust, and an experiment was conducted on the discharge reduction, where 18F is discharged without reacting with the FDG precursors during [18F]FDG synthesis and is immediately captured by the [18F]FDG automatic synthesis unit. Based on the performance evaluation results of the exhaust filter at the cyclotron facility of Chosun University, the measured capture efficiency before and after the filter was found to be 92%. Furthermore, the results of the discharge reduction experiment, where the exhaust 18F was immediately captured by the [18F]FDG synthesizer, showed a very satisfactory 94.3% reduction in the concentration of discharge compared to the existing discharge concentration.
Abstract
Recently, the number of PET cyclotrons has increased in Korea. A cyclotron mainly produces 18F, which is used for the production of [18F]FDG, a cancer diagnostic radiopharmaceutical. For radiation protection, the discharge control standard under the Nuclear Safety Act limits the radioactive concentration of 18F in the exhaust discharged from a nuclear power utilization facility to below 2,000 Bq m-3. However, the radioactive concentration of 18F discharged during [18F]FDG production at the cyclotron facility at Chosun University is maintained at about 1,500 Bq m-3 on average, which is 75% of the concentration limit of the discharge control standard, and temporarily exceeds the standard as per the real-time monitoring results. This study evaluated the performance of the exhaust filter unit of the cyclotron facility at Chosun University by assessing the concentration of 18F in the exhaust, and an experiment was conducted on the discharge reduction, where 18F is discharged without reacting with the FDG precursors during [18F]FDG synthesis and is immediately captured by the [18F]FDG automatic synthesis unit. Based on the performance evaluation results of the exhaust filter at the cyclotron facility of Chosun University, the measured capture efficiency before and after the filter was found to be 92%. Furthermore, the results of the discharge reduction experiment, where the exhaust 18F was immediately captured by the [18F]FDG synthesizer, showed a very satisfactory 94.3% reduction in the concentration of discharge compared to the existing discharge concentration.
참고문헌 (5)
- 사이클로트론 국내운영 실태 및 국내외 시설해체 기준 분석 평가, "한국원자력안전기술원", ~, pp.KINS (2013), HR-1269
- 한국원자력안전위원회, "방사선방호 등에 관한 기준", 한국원자력안전위원회 고시 2014-34호, ~ (2014)
- 정철기, "Evaluation of 18F Radioactive Concentration in Exhaust at Cyclotron Facility at Chosun University", 방사선산업학회지, 10(1), pp.37~41 (2016), (사)한국방사선산업학회
- 지대윤, "인체 영상용 방사성의약품의 개발", 공업화학, 14(3), pp.253~262 (2003), 한국공업화학회
- "Analysis on the domestic operation status and abroad decommissioning practices of radiation utilizing facilities", KINS, 2014