장기 중선량률의 감마선 피폭 기간에 따른 실험동물의생물학적 영향 연구
Biological Effects of Different Chronic Medium-Dose-Rate Gamma Radiation Period Exposed on Mice
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Recently, chronic gamma radiation exposure on biological effects in middle dose-rateshave become a serious concern. We investigated the biological effects of middle dose chronic exposureto gamma ray. Fifty male 6-week-old specific free Balb/c mice were randomly divided into fivegroups (four groups irradiated and one non-irradiated control group). Gamma radiation exposedin Gamma phytotron on Advanced Radiation Technology Institute (Jeongeup, Korea). Irradiationwas carried out for 1 or 2 weeks using gamma rays at dose rates of 45 and 50 mGy h-1 with totaldoses 7.56Gy (45 mGy h-1, 1 week), 8.4 Gy (50 mGy h-1, 1 week), 15.12 Gy (45 mGy h-1, 2 weeks) and16.8 Gy (50 mGy h-1, 2 weeks). After irradiation, immediately we sacrificed and counted body andorgan weights. Moreover we counted spleen cell numbers. Compared with control non-irradiatedgroup, all irradiated groups of body and spleen weights showed significant decreased. However, nosignificant alteration was observed between same irradiated period groups. In spleen cell numbers,reduced compared to the control group. However, significant alteration was observed betweensame irradiated period groups (45 mGy h-1, 50 mGy h-1). These results demonstrated biologicaleffects according to the radiation dose rate and irradiated period.
Abstract
Recently, chronic gamma radiation exposure on biological effects in middle dose-rateshave become a serious concern. We investigated the biological effects of middle dose chronic exposureto gamma ray. Fifty male 6-week-old specific free Balb/c mice were randomly divided into fivegroups (four groups irradiated and one non-irradiated control group). Gamma radiation exposedin Gamma phytotron on Advanced Radiation Technology Institute (Jeongeup, Korea). Irradiationwas carried out for 1 or 2 weeks using gamma rays at dose rates of 45 and 50 mGy h-1 with totaldoses 7.56Gy (45 mGy h-1, 1 week), 8.4 Gy (50 mGy h-1, 1 week), 15.12 Gy (45 mGy h-1, 2 weeks) and16.8 Gy (50 mGy h-1, 2 weeks). After irradiation, immediately we sacrificed and counted body andorgan weights. Moreover we counted spleen cell numbers. Compared with control non-irradiatedgroup, all irradiated groups of body and spleen weights showed significant decreased. However, nosignificant alteration was observed between same irradiated period groups. In spleen cell numbers,reduced compared to the control group. However, significant alteration was observed betweensame irradiated period groups (45 mGy h-1, 50 mGy h-1). These results demonstrated biologicaleffects according to the radiation dose rate and irradiated period.
참고문헌 (10)
- 도경현, "저선량 방사선이 인체에 미치는 영향", 대한의사협회지, 54(12), pp.1253~1261 (2011), 대한의사협회
- Halliwell B, "Free radicals in biology and medicine", pp.604~607 (1999), Oxford University Press
- Hendry JH, "The clonogen content of murine intestinal crypts : dependence on radiation dose used in its determination", Radiat. Res, 132, pp.115~119 (1992)
- Lacoste-Collin L, "Effects of continuous irradiation with a very low dose of gamma rays in life span and the immune system in SJL mice prone to Bcell lymphoma", Radiat. Res, 168(6), pp.725~732 (2007)
- National Research Council (US), "Health risks from exposure to low levels of ionizing radiation:BEIR VII phase2" (2006), National Academies Press
- Osipov AN, "In vivo γ-irradiation low dose threshold for suppression of DNA double strand breaks below the spontaneous level in mouse blood and spleen cells", Mutat. Res, 30(756), pp.141~145 (2013)
- 박은진, "감마선을 조사한 마우스의 조혈 및 소장줄기세포에 대한 fucoidan의 방호효과", 대한수의학회지, 48(4), pp.393~399 (2008), 대한수의학회
- Park HR, "Chronic effects of single and fractionated γ-irradiation on an impairment of Th-1 related immune response", Int. J. Radiat. Biol, 87(5), pp.534~543 (2011)
- Talmadge JE, "Protective, restorative, and therapeutic properties of recombinant colony-stimulating factors", Blood, 73, pp.2093~2103 (1989)
- Effect of ionizing radiation: UNSCEAR 2006 report to the general assembly with scientific annexes, "United Nations Scientific Committee on the Effects of Atomic Radiation", United Nations, ~ (2006)