Ionizing Radiation-Inducible delta-3-Carene in Lavender Leaves and Its Anticancer Effect against Various Cancer Cells
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Although essential oil of lavender has many beneficial effects on human health, little is knownabout its pharmacological effects on cancer cells. Here, we performed solid phase microextraction -gas chromatography - mass spectrometry analysis on volatile terpenoids from lavender (Lavandulaangustifolia L.) leaves in response to ionizing radiation and identified δ-3-carene, the only monoterpenehydrocarbon increased by γ-irradiation. When lavender leaves were exposed to γ-ray, relative ratio ofmonoterpene hydrocarbons such as limonene and camphene decreased, but that of δ-3-carene wasup-regulated. In pharmacological test, δ-3-carene had suppressive effect on the growth of lung (A549),prostate (PC3 and LNCaP), colon (SW480), breast (MCF7), and liver human cancer cells (Huh7) with anIC50<150 μg mL-1 for A549, MCF7, PC3, and LNCaP. Together, δ-3-carene, a γ-ray-inducible volatile inlavender leaves, has inhibitory effects on various cancer cells. These results suggest that δ-3-carene canbe a compound of interest as a therapeutic candidate for the study on lung and prostate cancers.
Abstract
Although essential oil of lavender has many beneficial effects on human health, little is knownabout its pharmacological effects on cancer cells. Here, we performed solid phase microextraction -gas chromatography - mass spectrometry analysis on volatile terpenoids from lavender (Lavandulaangustifolia L.) leaves in response to ionizing radiation and identified δ-3-carene, the only monoterpenehydrocarbon increased by γ-irradiation. When lavender leaves were exposed to γ-ray, relative ratio ofmonoterpene hydrocarbons such as limonene and camphene decreased, but that of δ-3-carene wasup-regulated. In pharmacological test, δ-3-carene had suppressive effect on the growth of lung (A549),prostate (PC3 and LNCaP), colon (SW480), breast (MCF7), and liver human cancer cells (Huh7) with anIC50<150 μg mL-1 for A549, MCF7, PC3, and LNCaP. Together, δ-3-carene, a γ-ray-inducible volatile inlavender leaves, has inhibitory effects on various cancer cells. These results suggest that δ-3-carene canbe a compound of interest as a therapeutic candidate for the study on lung and prostate cancers.
참고문헌 (23)
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