Bone Mineral Density Changes After Total Knee Replacement in Women Over the Age of 65
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Background: There are few reports on bone mineral density (BMD) changes of axial bones after total knee replacement (TKR) due to severe osteoarthritis (OA) of the knee joint and its results are controversial. The purpose of our study was to measure the BMD changes of hip and spine in patients receiving TKR due to severe OA and to identify clini-cal factors relating BMD changes. Methods: Among 66 female patients above 65 years old who underwent TKR due to severe OA and checked preoperative BMD, 52 patients who checked 1 year follow up BMD were enrolled. We investigated the association of the BMD changes with bilaterality of operation, obesity, preoperative knee functional scores, bisphosphonate medication, and diagnosis of osteoporosis. Results: We found no correlation between BMD changes and bilaterality of operation, obesity, preopera-tive knee functional scores and diagnosis of osteoporosis. Spine BMD increased in non-treatment and bisphosphonate treatment group but total hip BMD significantly increas-ed in bisphosphonate treatment group. Conclusions: Bisphosphonate treatment for 1year prevents early reduction of hip BMD just after TKR regardless osteoporosis diagno-sis. We considered that the bisphosphonate medication would be beneficial to preven-tion of later hip fracture in elderly patient receiving TKR due to severe OA of knee joints.
Abstract
Background: There are few reports on bone mineral density (BMD) changes of axial bones after total knee replacement (TKR) due to severe osteoarthritis (OA) of the knee joint and its results are controversial. The purpose of our study was to measure the BMD changes of hip and spine in patients receiving TKR due to severe OA and to identify clini-cal factors relating BMD changes. Methods: Among 66 female patients above 65 years old who underwent TKR due to severe OA and checked preoperative BMD, 52 patients who checked 1 year follow up BMD were enrolled. We investigated the association of the BMD changes with bilaterality of operation, obesity, preoperative knee functional scores, bisphosphonate medication, and diagnosis of osteoporosis. Results: We found no correlation between BMD changes and bilaterality of operation, obesity, preopera-tive knee functional scores and diagnosis of osteoporosis. Spine BMD increased in non-treatment and bisphosphonate treatment group but total hip BMD significantly increas-ed in bisphosphonate treatment group. Conclusions: Bisphosphonate treatment for 1year prevents early reduction of hip BMD just after TKR regardless osteoporosis diagno-sis. We considered that the bisphosphonate medication would be beneficial to preven-tion of later hip fracture in elderly patient receiving TKR due to severe OA of knee joints.
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