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Interaction between Muscle and Bone

Hiroshi Kaji
대한골대사학회 (The Korean Society of Bone Metabolism)|2014.02|대한골대사학회지 (Journal of Bone Metabolism)|제21권 제1호|pp. 29-40

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참고문헌

키워드

OsteoporosisSarcopeniaMusclesBone and bones
주제분류정형외과학

초록

The clinical significance of sarcopenia and osteoporosis has increased with the increasein the population of older people. Sarcopenia is defined by decreased muscle mass andimpaired muscle function, which is related to osteoporosis independently and depend-ently. Numerous lines of clinical evidence suggest that lean body mass is positively relat-ed to bone mass, which leads to reduced fracture risk. Genetic, endocrine and mechani-cal factors affect both muscle and bone simultaneously. Vitamin D, the growth hor-mone/insulin-like growth factor I axis and testosterone are physiologically and patho-logically important as endocrine factors. These findings suggest the presence of interac-tions between muscle and bone, which might be very important for understanding thephysiology and pathophysiology of sarcopenia and osteoporosis. Muscle/bone relation-ships include two factors: local control of muscle to bone and systemic humoral interac-tions between muscle and bone. As a putative local inducer of muscle ossification, wefound Tmem119, a parathyroid hormone-responsive osteoblast differentiation factor. Moreover, osteoglycin might be one of the muscle-derived humoral bone anabolic fac-tors. This issue may be important for the development of novel drugs and biomarkersfor osteoporosis and sarcopenia. Further research will be necessary to clarify the detailsof the linkage of muscle and bone.

Abstract

The clinical significance of sarcopenia and osteoporosis has increased with the increasein the population of older people. Sarcopenia is defined by decreased muscle mass andimpaired muscle function, which is related to osteoporosis independently and depend-ently. Numerous lines of clinical evidence suggest that lean body mass is positively relat-ed to bone mass, which leads to reduced fracture risk. Genetic, endocrine and mechani-cal factors affect both muscle and bone simultaneously. Vitamin D, the growth hor-mone/insulin-like growth factor I axis and testosterone are physiologically and patho-logically important as endocrine factors. These findings suggest the presence of interac-tions between muscle and bone, which might be very important for understanding thephysiology and pathophysiology of sarcopenia and osteoporosis. Muscle/bone relation-ships include two factors: local control of muscle to bone and systemic humoral interac-tions between muscle and bone. As a putative local inducer of muscle ossification, wefound Tmem119, a parathyroid hormone-responsive osteoblast differentiation factor. Moreover, osteoglycin might be one of the muscle-derived humoral bone anabolic fac-tors. This issue may be important for the development of novel drugs and biomarkersfor osteoporosis and sarcopenia. Further research will be necessary to clarify the detailsof the linkage of muscle and bone.

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