골대사에서의 마이오카인 아이리신 역할
The role of myokine Irisin on bone metabolism
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Several studies have recently demonstrated that skeletal muscle is an endocrine organ releasing and expressing myokines acting in an endocrine or paracrine manner. Irisin is a hormene-like myokine induced after physical exercise by muscle fibers. It was primarily recognized as a molecule able to advance the “browning response” in white adipose tissue, however, it has been recetly identified that irisin also has a fundamental role in the control of bone mass. We study evidence for its possible skeletal effects, including the fundamental role that irisin is involved in the control of bone mass, with beneficial effects on geometry and cortical mineral density. As loss of muscle mass and bone density occurs with immobility, metabolic disease and aging, future studies researching the efficacy of irisin in reversing muscle wasting and restoring bone would be important to proving irisin as a molecule that combines helpful effects for treating muscular atrophy and osteoporosis in elderly people.
Abstract
Several studies have recently demonstrated that skeletal muscle is an endocrine organ releasing and expressing myokines acting in an endocrine or paracrine manner. Irisin is a hormene-like myokine induced after physical exercise by muscle fibers. It was primarily recognized as a molecule able to advance the “browning response” in white adipose tissue, however, it has been recetly identified that irisin also has a fundamental role in the control of bone mass. We study evidence for its possible skeletal effects, including the fundamental role that irisin is involved in the control of bone mass, with beneficial effects on geometry and cortical mineral density. As loss of muscle mass and bone density occurs with immobility, metabolic disease and aging, future studies researching the efficacy of irisin in reversing muscle wasting and restoring bone would be important to proving irisin as a molecule that combines helpful effects for treating muscular atrophy and osteoporosis in elderly people.
참고문헌 (44)
- J. Y. Reginster, "Osteoporosis and sarcopenia : two diseases or one?", Current opinion in clinical nutrition and metabolic care, 19(1), pp.31~ (2015)
- D. Dunstan, "Diabetes : exercise and T2DM-move muscles more often!", Nat. Rev. Endocrinol, 7(4), pp.189~190 (2011)
- B. Egan, "Exercise metabolism and the molecular regulation of skeletal muscle adaptation", Cell Metabolism, 17(2), pp.162~184 (2013)
- G. Colaianni, "Crosstalk between muscle and bone via the muscle-myokine irisin", Current osteoporosis reports, 14(4), pp.132~137 (2016)
- H. H. Jones, "Humeral hypertrophy in response to exercise", Journal of Bone and Joint Surgery A, 59(2), pp.204~208 (1977)
- C. M. Girgis, "Therapies for musculoskeletal disease : can we treat two birds with one stone?", Current osteoporosis reports, 12(2), pp.142~153 (2014)
- C. Tagliaferri, "Muscle and bone, two interconnected tissues", Ageing research reviews, 21, pp.55~70 (2015)
- L. F. Bonewald, "Osteocytes as dynamic multifunctional cells", Annals of the New York Academy of Sciences, 1116(1), pp.281~290 (2007)
- L. F. Bonewald, "Osteocytes, mechanosensing and Wnt signaling", Bone, 42(4), pp.606~615 (2008)
- Y. Li, "Notch signaling as an important mediator of cardiac repair and regeneration after myocardial infarction", Trends in cardiovascular medicine, 20(7), pp.228~231 (2010)
- R. S. Rainbow, "Muscle cell-derived factors inhibit inflammatory stimuliinduced damage in hMSC-derived chondrocytes", Osteoarthritis and cartilage, 21(7), pp.990~998 (2013)
- J. N. Regan, "The role of TGFβ in bone-muscle crosstalk", Current osteoporosis reports, 15(1), pp.18~23 (2017)
- P. Boström, "A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis", Nature, 481(7382), pp.463~468 (2012)
- G. Colaianni, "Irisin enhances osteoblast differentiation in vitro", International journal of endocrinology, 2014, pp.8~ (2014)
- G. Colaianni, "The Myokine Irisin increases cortical bone mass", Proceedings of the National Academy of Sciences, 112(39), pp.12157~12162 (2015)
- B. K. Pedersen, "Muscles, exercise and obesity : skeletal muscle as a secretory organ", Nature Reviews Endocrinology, 8(8), pp.457~465 (2012)
- N. A. Sims, "Cell-specific paracrine actions of IL-6family cytokines from bone, marrow and muscle that control bone formation and resorption", The international journal of biochemistry & cell biology, 79, pp.14~23 (2016)
- S. Schnyder, "Skeletal muscle as an endocrine organ : PGC-1 alpha, myokines and exercise", Bone, 80, pp.115~125 (2015)
- B. K. Pedersen, "Muscle as a secretory organ", Comprehensive Physiology, 3(3), pp.1337~1362 (2013)
- L. F. Wu, "Relative abundance of mature myostatin rather than total myostatin is negatively associated with bone mineral density in Chinese", Journal of cellular and molecular medicine, 22(2), pp.1329~1336 (2017)
- H. Kim, "Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors", Cell, 175(7), pp.1756~1768 (2018)
- M. W. Berchtold, "Calcium ion in skeletal muscle : its crucial role for muscle function, plasticity, and disease", Physiological reviews, 80(3), pp.1215~1265 (2000)
- A. P. Russell, "Endurance training in humans leads to fiber type-specific increases in levels of peroxisome proliferator-activated receptor-γ coactivator-1 and peroxisome proliferator-activated receptor-α in skeletal muscle", Diabetes, 52(12), pp.2874~2881 (2003)
- T. G. Brock, "Weight Loss: A New Star is Irisin", ~ (2015)
- R. A. Vaughan, "Irisin, a unique non-inflammatory myokine in stimulating skeletal muscle metabolism", Journal of physiology and biochemistry, 71(4), pp.679~689 (2015)
- Y. Zhang, "Irisin stimulates browning of white adipocytes through mitogen-activated protein kinase p38 MAP kinase and ERK MAP kinase signaling", Diabetes, 63(2), pp.514~525 (2014)
- G. Colaianni, "Irisin prevents and restores boneloss and muscle atrophy in hind-limb suspended mice", Scientific reports, 7(1), pp.2811~ (2017)
- X. Li, "Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength", Journal of Bone and Mineral Research, 23(6), pp.860~869 (2009)
- X. Y. Qiao, "Irisin promotes osteoblast proliferation and differentiation via activating the MAP kinase signaling pathways", Sci Rep, 6(18732) (2016)
- A. D. Anastasilakis, "Circulating irisin is associated with osteoporotic fractures in postmenopausal women with low bone mass but is not affected by either teriparatide or denosumab treatment for 3 months", Osteoporosis international, 25(5), pp.1633~1642 (2014)
- V. Singhal, "Irisin levels are lower in young amenorrheic athletes compared with eumenorrheic athletes and non-athletes and are associated with bone density and strength estimates", PLoS ONE, 9(6), pp.e100218~ (2014)
- G. Colaianni, "Irisin levels correlate with bone mineral density in soccer players", Journal of biological regulators and homeostatic agents, 31(4-1), pp.21~28 (2017)
- G. Colaianni, "Irisin and Bone : From Preclinical Studies to the Evaluation of Its Circulating Levels in Different Populations of Human Subjects", Cells, 8(5), pp.451~ (2019)
- A. Palermo, "Irisin is associated with osteoporotic fractures independently of bone mineral density, body composition or daily physical activity", Clin. Endocrinol, 82(4), pp.1615~1619 (2015)
- T. Klangjareonchai, "Circulating sclerostin and Irisin are related and interact with gender to influence adiposity in adults with prediabetes", Int. J. Endocrinol, 2014, pp.6~ (2014)
- Y. Tsuchiya, "Resistance exercise induces a greater irisin response than endurance exercise", Metabolism, 64(9), pp.1042~1050 (2015)
- Y. Tsuchiya, "High-intensity exercise causes greater irisin response compared with low-intensity exercise under similar energy consumption", Tohoku J. Exp, 223(2), pp.135~140 (2014)
- S. Soininen, "Body fat mass, lean body mass and associated biomarkers as determinants of bone mineral density in children 6–8 years of age—The Physical Activity and Nutrition in Children(PANIC)study", Bone, 108, pp.106~114 (2018)
- J. Y. Huh, "Exercise-induced irisin secretion is independent of age or fitness level and increased irisin may directly modulate muscle metabolism through AMPK activation", The Journal of Clinical Endocrinology & Metabolism, 99(11), pp.E2154~E2161 (2014)
- T. Shan, "Myostatin knockout drives browning of white adipose tissue through activating the AMPK-PGC1α-Fndc5 pathway in muscle", The FASEB Journal, 27(5), pp.1981~1989 (2013)
- M. G. MacKenzie, "Inhibition of myostatin signaling through Notch activation following acute resistance exercise", PloS one, 8(7), pp.e68743~ (2013)
- M. N. Elkasrawy, "Myostatin(GDF-8)as a key factor linking muscle mass and skeletal form", Journal of musculoskeletal & neuronal interactions, 10(1), pp.56~63 (2010)
- Y. Wan, "iBAT on Bone", Endocrinology, 154(8), pp.2579~2580 (2013)
- S. Rahman, "Inducible brown adipose tissue, or beige fat, is anabolic for the skeleton", Endocrinology, 154(8), pp.2687~2701 (2013)