The Role of Titanium Particles and Ions in the Pathogenesis of Peri-Implantitis
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Titanium (Ti) particles and ions have been investigated in recent years as important fac- tors in the pathogenesis of peri-implantitis. However, their role in the pathogenesis is yet to be fully understood. A review of pertinent literature was performed in various da- tabases to determine the current position of Ti particles and ions role in the pathogene- sis of peri-implantitis. There are several in vitro, preclinical and clinical published studies that have addressed the role of Ti particles and ions in the pathogenesis of peri-implan- titis. These studies explored the effect of Ti particles and ions in the pathogenesis of peri- implantitis with respect to foreign body reaction, cellular response, epigenetic mecha- nisms, namely DNA methylation, and the oral microbiome. Studies have shown that the release of Ti particles/ions during implant insertion, early healing stages, late healing stages, and treatments during peri-implantitis might contribute to peri-implantitis through different mechanisms, such as foreign body reaction, cellular response, DNA methyla- tion, and shaping the oral microbiome by increasing dysbiosis. However, further studies are needed to elucidate the complex interactions between all these mechanisms and Ti particles/ions in the pathogenesis and progression of peri-implantitis.
Abstract
Titanium (Ti) particles and ions have been investigated in recent years as important fac- tors in the pathogenesis of peri-implantitis. However, their role in the pathogenesis is yet to be fully understood. A review of pertinent literature was performed in various da- tabases to determine the current position of Ti particles and ions role in the pathogene- sis of peri-implantitis. There are several in vitro, preclinical and clinical published studies that have addressed the role of Ti particles and ions in the pathogenesis of peri-implan- titis. These studies explored the effect of Ti particles and ions in the pathogenesis of peri- implantitis with respect to foreign body reaction, cellular response, epigenetic mecha- nisms, namely DNA methylation, and the oral microbiome. Studies have shown that the release of Ti particles/ions during implant insertion, early healing stages, late healing stages, and treatments during peri-implantitis might contribute to peri-implantitis through different mechanisms, such as foreign body reaction, cellular response, DNA methyla- tion, and shaping the oral microbiome by increasing dysbiosis. However, further studies are needed to elucidate the complex interactions between all these mechanisms and Ti particles/ions in the pathogenesis and progression of peri-implantitis.
참고문헌 (55)
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