본문 바로가기
KERD
논문KCI 등재

Roles of Follicle-Stimulating Hormone on Bone Metabolism in Late Postmenopausal Women

1

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류정형외과학

초록

Background: The effects of elevated follicle-stimulating hormone (FSH) levels on physi- ological changes in the bone remain unclear. This study aimed to clarify the association between FSH concentrations and bone mineral density (BMD) and bone turnover mark- ers (BTM) in late postmenopausal women. Methods: A total of 169 Korean women were enrolled. The participants’ ages ranged from 60 to 84 years (mean age, 69.0±5.1) and reported a mean duration of 19.4±6.6 years since menopause (YSM). The participants showed an average body mass index (BMI) of 24.4±2.8 kg/m2. Age, YSM, estradiol, tes- tosterone, and BMI were confounders in the Pearson's partial correlation. A test for trends across the quartiles of FSH levels was performed for each variable. Results: The mean FSH and estradiol concentrations were 61.5 IU/L and 2.9 pg/mL, respectively. Serum FSH concentration was not significantly associated with BMD (lumbar, r = 0.09, P = 0.30; total hip, r = 0.00, P = 0.96; and femoral neck, r = 0.05, P = 0.62). BTM across the FSH quartiles did not show any trend association (bone-specific alkaline phosphate, P = 0.31; cross- linked C-terminal telopeptide of type I collagen, P = 0.90). Instead, FSH levels were nega- tively correlated with BMI (r = -0.34, P = 0.00). In the multivariate regression model ad- justed for age, testosterone, and estradiol, only BMI showed a negative value across the FSH quartiles (β coefficient -0.11, P = 0.00). Conclusions: This study identified that high FSH concentrations were not associated with bone loss or high bone turnover in women in the late postmenopausal period.

Abstract

Background: The effects of elevated follicle-stimulating hormone (FSH) levels on physi- ological changes in the bone remain unclear. This study aimed to clarify the association between FSH concentrations and bone mineral density (BMD) and bone turnover mark- ers (BTM) in late postmenopausal women. Methods: A total of 169 Korean women were enrolled. The participants’ ages ranged from 60 to 84 years (mean age, 69.0±5.1) and reported a mean duration of 19.4±6.6 years since menopause (YSM). The participants showed an average body mass index (BMI) of 24.4±2.8 kg/m2. Age, YSM, estradiol, tes- tosterone, and BMI were confounders in the Pearson's partial correlation. A test for trends across the quartiles of FSH levels was performed for each variable. Results: The mean FSH and estradiol concentrations were 61.5 IU/L and 2.9 pg/mL, respectively. Serum FSH concentration was not significantly associated with BMD (lumbar, r = 0.09, P = 0.30; total hip, r = 0.00, P = 0.96; and femoral neck, r = 0.05, P = 0.62). BTM across the FSH quartiles did not show any trend association (bone-specific alkaline phosphate, P = 0.31; cross- linked C-terminal telopeptide of type I collagen, P = 0.90). Instead, FSH levels were nega- tively correlated with BMI (r = -0.34, P = 0.00). In the multivariate regression model ad- justed for age, testosterone, and estradiol, only BMI showed a negative value across the FSH quartiles (β coefficient -0.11, P = 0.00). Conclusions: This study identified that high FSH concentrations were not associated with bone loss or high bone turnover in women in the late postmenopausal period.

참고문헌 (38)

  1. Sun L, "FSH directly regulates bone mass", Cell, 125, pp.247~260 (2006)[DOI]
  2. Sowers MR, "The association of endogenous hormone concentrations and bone mineral density measures in pre-and perimenopausal women of four ethnic groups : SWAN", Osteoporos Int, 14, pp.44~52 (2003)[DOI]
  3. Sowers MR, "Endogenous hormones and bone turnover markers in pre-and perimenopausal women : SWAN", Osteoporos Int, 14, pp.191~197 (2003)[DOI]
  4. Sowers MR, "Hormone predictors of bone mineral density changes during the menopausal transition", J Clin Endocrinol Metab, 91, pp.1261~1267 (2006)[DOI]
  5. Devleta B, "Hypergonadotropic amenorrhea and bone density : new approach to an old problem", J Bone Miner Metab, 22, pp.360~364 (2004)[DOI]
  6. Shieh A, "Estradiol and follicle-stimulating hormone as predictors of onset of menopause transition-related bone loss in pre-and perimenopausal women", J Bone Miner Res, 34, pp.2246~2253 (2019)[DOI]
  7. Cannon JG, "Follicle-stimulating hormone, interleukin-1, and bone density in adult women", Am J Physiol Regul Integr Comp Physiol, 298, pp.R790~R798 (2010)[DOI]
  8. García-Martín A, "Role of serum FSH measurement on bone resorption in postmenopausal women", Endocrine, 41, pp.302~308 (2012)[DOI]
  9. Grewal J, "Low bone mineral density in the early menopausal transition : role for ovulatory function", J Clin Endocrinol Metab, 91, pp.3780~3785 (2006)[DOI]
  10. Wu XY, "Early bone mineral density decrease is associated with FSH and LH, not estrogen", Clin Chim Acta, 415, pp.69~73 (2013)[DOI]
  11. Wang J, "Follicle-stimulating hormone increases the risk of postmenopausal osteoporosis by stimulating osteoclast differentiation", PLoS One, 10, pp.e0134986~ (2015)[DOI]
  12. Ebeling PR, "Bone turnover markers and bone density across the menopausal transition", J Clin Endocrinol Metab, 81, pp.3366~3371 (1996)[DOI]
  13. Vural F, "Ovarian aging and bone metabolism in menstruating women aged 35-50 years", Maturitas, 52, pp.147~153 (2005)[DOI]
  14. Qian H, "FSH aggravates bone loss in ovariectomised rats with experimental periapical periodontitis", Mol Med Rep, 14, pp.2997~3006 (2016)[DOI]
  15. Tepper PG, "Trajectory clustering of estradiol and follicle-stimulating hormone during the menopausal transition among women in the Study of Women's Health across the Nation(SWAN)", J Clin Endocrinol Metab, 97, pp.2872~2880 (2012)[DOI]
  16. "Obesity(Silver Spring)", 2015, 228~233, https:
  17. Adami S, "Determinants of bone turnover markers in healthy premenopausal women", Calcif Tissue Int, 82, pp.341~347 (2008)[DOI]
  18. Liu S, "FSH aggravates periodontitis-related bone loss in ovariectomized rats", J Dent Res, 89, pp.366~371 (2010)[DOI]
  19. Ji Y, "Epitope-specific monoclonal antibodies to FSHβ increase bone mass", Proc Natl Acad Sci U S A, 115, pp.2192~2197 (2018)[DOI]
  20. Liu P, "Blocking FSH induces thermogenic adipose tissue and reduces body fat", Nature, 546, pp.107~112 (2017)[DOI]
  21. Wu KC, "FSH level and changes in bone mass and body composition in older women and men", J Clin Endocrinol Metab, 106, pp.2876~2889 (2021)[DOI]
  22. Drake MT, "Effects of suppression of follicle-stimulating hormone secretion on bone resorption markers in postmenopausal women", J Clin Endocrinol Metab, 95, pp.5063~5068 (2010)[DOI]
  23. Crandall CJ, "Serum sex steroid levels and longitudinal changes in bone density in relation to the final menstrual period", J Clin Endocrinol Metab, 98, pp.E654~E663 (2013)[DOI]
  24. Williams GR, "Hypogonadal bone loss : sex steroids or gonadotropins?", Endocrinology, 148, pp.2610~2612 (2007)[DOI]
  25. Soules MR, "Executive summary: Stages of Reproductive Aging Workshop (STRAW) Park City, Utah, July, 2001", Menopause, 8, pp.402~407 (2001)[DOI]
  26. Wu XY, "Age-related changes in biochemical markers of bone turnover and gonadotropin levels and their relationship among Chinese adult women", Osteoporos Int, 21, pp.275~285 (2010)[DOI]
  27. Xu ZR, "Relationship of age-related concentrations of serum FSH and LH with bone mineral density, prevalence of osteoporosis in native Chinese women", Clin Chim Acta, 400, pp.8~13 (2009)[DOI]
  28. Perrien DS, "Bone turnover across the menopause transition : correlations with inhibins and follicle-stimulating hormone", J Clin Endocrinol Metab, 91, pp.1848~1854 (2006)[DOI]
  29. Desai Meena P, "Hormonal profiles and biochemical indices of bone turnover in Indian women", Osteoporos Int, 18, pp.923~929 (2007)[DOI]
  30. Cheung E, "Bone loss during menopausal transition among southern Chinese women", Maturitas, 69, pp.50~56 (2011)[DOI]
  31. Gourlay ML, "Follicle-stimulating hormone is independently associated with lean mass but not BMD in younger postmenopausal women", Bone, 50, pp.311~316 (2012)[DOI]
  32. Allan CM, "Follicle-stimulating hormone increases bone mass in female mice", Proc Natl Acad Sci U S A, 107, pp.22629~22634 (2010)[DOI]
  33. Amsterdam A, "Mechanisms of gonadotropin desensitization", Mol Cell Endocrinol, 187, pp.69~74 (2002)[DOI]
  34. Mazzuoli G, "Annual skeletal balance and metabolic bone marker changes in healthy early postmenopausal women : results of a prospective study", Bone, 26, pp.381~386 (2000)[DOI]
  35. Veldhuis-Vlug AG, "Serum FSH Is associated with BMD, bone marrow adiposity, and body composition in the AGES-Reykjavik study of older adults", J Clin Endocrinol Metab, 106, pp.e1156~e1169 (2021)[DOI]
  36. Mohammad Reza Salamat, "Association between Obesity and Bone Mineral Density by Gender and Menopausal Status", Endocrinology and Metabolism, 31(4), pp.547~558 (2016), 대한내분비학회
  37. Randolph JF, Jr., "Reproductive hormones in the early menopausal transition: relationship to ethnicity, body size, and menopausal status", J Clin Endocrinol Metab, 88, pp.1516~1522 (2003)[DOI]
  38. Garnero P, "The type I collagen fragments ICTP and CTX reveal distinct enzymatic pathways of bone collagen degradation", J Bone Miner Res, 18, pp.859~867 (2003)[DOI]

관련 논문AI추천

이 간행물의 다른 논문 (6건)