Roles of Follicle-Stimulating Hormone on Bone Metabolism in Late Postmenopausal Women
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Background: The effects of elevated follicle-stimulating hormone (FSH) levels on physi- ological changes in the bone remain unclear. This study aimed to clarify the association between FSH concentrations and bone mineral density (BMD) and bone turnover mark- ers (BTM) in late postmenopausal women. Methods: A total of 169 Korean women were enrolled. The participants’ ages ranged from 60 to 84 years (mean age, 69.0±5.1) and reported a mean duration of 19.4±6.6 years since menopause (YSM). The participants showed an average body mass index (BMI) of 24.4±2.8 kg/m2. Age, YSM, estradiol, tes- tosterone, and BMI were confounders in the Pearson's partial correlation. A test for trends across the quartiles of FSH levels was performed for each variable. Results: The mean FSH and estradiol concentrations were 61.5 IU/L and 2.9 pg/mL, respectively. Serum FSH concentration was not significantly associated with BMD (lumbar, r = 0.09, P = 0.30; total hip, r = 0.00, P = 0.96; and femoral neck, r = 0.05, P = 0.62). BTM across the FSH quartiles did not show any trend association (bone-specific alkaline phosphate, P = 0.31; cross- linked C-terminal telopeptide of type I collagen, P = 0.90). Instead, FSH levels were nega- tively correlated with BMI (r = -0.34, P = 0.00). In the multivariate regression model ad- justed for age, testosterone, and estradiol, only BMI showed a negative value across the FSH quartiles (β coefficient -0.11, P = 0.00). Conclusions: This study identified that high FSH concentrations were not associated with bone loss or high bone turnover in women in the late postmenopausal period.
Abstract
Background: The effects of elevated follicle-stimulating hormone (FSH) levels on physi- ological changes in the bone remain unclear. This study aimed to clarify the association between FSH concentrations and bone mineral density (BMD) and bone turnover mark- ers (BTM) in late postmenopausal women. Methods: A total of 169 Korean women were enrolled. The participants’ ages ranged from 60 to 84 years (mean age, 69.0±5.1) and reported a mean duration of 19.4±6.6 years since menopause (YSM). The participants showed an average body mass index (BMI) of 24.4±2.8 kg/m2. Age, YSM, estradiol, tes- tosterone, and BMI were confounders in the Pearson's partial correlation. A test for trends across the quartiles of FSH levels was performed for each variable. Results: The mean FSH and estradiol concentrations were 61.5 IU/L and 2.9 pg/mL, respectively. Serum FSH concentration was not significantly associated with BMD (lumbar, r = 0.09, P = 0.30; total hip, r = 0.00, P = 0.96; and femoral neck, r = 0.05, P = 0.62). BTM across the FSH quartiles did not show any trend association (bone-specific alkaline phosphate, P = 0.31; cross- linked C-terminal telopeptide of type I collagen, P = 0.90). Instead, FSH levels were nega- tively correlated with BMI (r = -0.34, P = 0.00). In the multivariate regression model ad- justed for age, testosterone, and estradiol, only BMI showed a negative value across the FSH quartiles (β coefficient -0.11, P = 0.00). Conclusions: This study identified that high FSH concentrations were not associated with bone loss or high bone turnover in women in the late postmenopausal period.
참고문헌 (38)
- Sun L, "FSH directly regulates bone mass", Cell, 125, pp.247~260 (2006)[DOI]
- Sowers MR, "The association of endogenous hormone concentrations and bone mineral density measures in pre-and perimenopausal women of four ethnic groups : SWAN", Osteoporos Int, 14, pp.44~52 (2003)[DOI]
- Sowers MR, "Endogenous hormones and bone turnover markers in pre-and perimenopausal women : SWAN", Osteoporos Int, 14, pp.191~197 (2003)[DOI]
- Sowers MR, "Hormone predictors of bone mineral density changes during the menopausal transition", J Clin Endocrinol Metab, 91, pp.1261~1267 (2006)[DOI]
- Devleta B, "Hypergonadotropic amenorrhea and bone density : new approach to an old problem", J Bone Miner Metab, 22, pp.360~364 (2004)[DOI]
- Shieh A, "Estradiol and follicle-stimulating hormone as predictors of onset of menopause transition-related bone loss in pre-and perimenopausal women", J Bone Miner Res, 34, pp.2246~2253 (2019)[DOI]
- Cannon JG, "Follicle-stimulating hormone, interleukin-1, and bone density in adult women", Am J Physiol Regul Integr Comp Physiol, 298, pp.R790~R798 (2010)[DOI]
- García-Martín A, "Role of serum FSH measurement on bone resorption in postmenopausal women", Endocrine, 41, pp.302~308 (2012)[DOI]
- Grewal J, "Low bone mineral density in the early menopausal transition : role for ovulatory function", J Clin Endocrinol Metab, 91, pp.3780~3785 (2006)[DOI]
- Wu XY, "Early bone mineral density decrease is associated with FSH and LH, not estrogen", Clin Chim Acta, 415, pp.69~73 (2013)[DOI]
- Wang J, "Follicle-stimulating hormone increases the risk of postmenopausal osteoporosis by stimulating osteoclast differentiation", PLoS One, 10, pp.e0134986~ (2015)[DOI]
- Ebeling PR, "Bone turnover markers and bone density across the menopausal transition", J Clin Endocrinol Metab, 81, pp.3366~3371 (1996)[DOI]
- Vural F, "Ovarian aging and bone metabolism in menstruating women aged 35-50 years", Maturitas, 52, pp.147~153 (2005)[DOI]
- Qian H, "FSH aggravates bone loss in ovariectomised rats with experimental periapical periodontitis", Mol Med Rep, 14, pp.2997~3006 (2016)[DOI]
- Tepper PG, "Trajectory clustering of estradiol and follicle-stimulating hormone during the menopausal transition among women in the Study of Women's Health across the Nation(SWAN)", J Clin Endocrinol Metab, 97, pp.2872~2880 (2012)[DOI]
- "Obesity(Silver Spring)", 2015, 228~233, https:
- Adami S, "Determinants of bone turnover markers in healthy premenopausal women", Calcif Tissue Int, 82, pp.341~347 (2008)[DOI]
- Liu S, "FSH aggravates periodontitis-related bone loss in ovariectomized rats", J Dent Res, 89, pp.366~371 (2010)[DOI]
- Ji Y, "Epitope-specific monoclonal antibodies to FSHβ increase bone mass", Proc Natl Acad Sci U S A, 115, pp.2192~2197 (2018)[DOI]
- Liu P, "Blocking FSH induces thermogenic adipose tissue and reduces body fat", Nature, 546, pp.107~112 (2017)[DOI]
- Wu KC, "FSH level and changes in bone mass and body composition in older women and men", J Clin Endocrinol Metab, 106, pp.2876~2889 (2021)[DOI]
- Drake MT, "Effects of suppression of follicle-stimulating hormone secretion on bone resorption markers in postmenopausal women", J Clin Endocrinol Metab, 95, pp.5063~5068 (2010)[DOI]
- Crandall CJ, "Serum sex steroid levels and longitudinal changes in bone density in relation to the final menstrual period", J Clin Endocrinol Metab, 98, pp.E654~E663 (2013)[DOI]
- Williams GR, "Hypogonadal bone loss : sex steroids or gonadotropins?", Endocrinology, 148, pp.2610~2612 (2007)[DOI]
- Soules MR, "Executive summary: Stages of Reproductive Aging Workshop (STRAW) Park City, Utah, July, 2001", Menopause, 8, pp.402~407 (2001)[DOI]
- Wu XY, "Age-related changes in biochemical markers of bone turnover and gonadotropin levels and their relationship among Chinese adult women", Osteoporos Int, 21, pp.275~285 (2010)[DOI]
- Xu ZR, "Relationship of age-related concentrations of serum FSH and LH with bone mineral density, prevalence of osteoporosis in native Chinese women", Clin Chim Acta, 400, pp.8~13 (2009)[DOI]
- Perrien DS, "Bone turnover across the menopause transition : correlations with inhibins and follicle-stimulating hormone", J Clin Endocrinol Metab, 91, pp.1848~1854 (2006)[DOI]
- Desai Meena P, "Hormonal profiles and biochemical indices of bone turnover in Indian women", Osteoporos Int, 18, pp.923~929 (2007)[DOI]
- Cheung E, "Bone loss during menopausal transition among southern Chinese women", Maturitas, 69, pp.50~56 (2011)[DOI]
- Gourlay ML, "Follicle-stimulating hormone is independently associated with lean mass but not BMD in younger postmenopausal women", Bone, 50, pp.311~316 (2012)[DOI]
- Allan CM, "Follicle-stimulating hormone increases bone mass in female mice", Proc Natl Acad Sci U S A, 107, pp.22629~22634 (2010)[DOI]
- Amsterdam A, "Mechanisms of gonadotropin desensitization", Mol Cell Endocrinol, 187, pp.69~74 (2002)[DOI]
- Mazzuoli G, "Annual skeletal balance and metabolic bone marker changes in healthy early postmenopausal women : results of a prospective study", Bone, 26, pp.381~386 (2000)[DOI]
- Veldhuis-Vlug AG, "Serum FSH Is associated with BMD, bone marrow adiposity, and body composition in the AGES-Reykjavik study of older adults", J Clin Endocrinol Metab, 106, pp.e1156~e1169 (2021)[DOI]
- Mohammad Reza Salamat, "Association between Obesity and Bone Mineral Density by Gender and Menopausal Status", Endocrinology and Metabolism, 31(4), pp.547~558 (2016), 대한내분비학회
- Randolph JF, Jr., "Reproductive hormones in the early menopausal transition: relationship to ethnicity, body size, and menopausal status", J Clin Endocrinol Metab, 88, pp.1516~1522 (2003)[DOI]
- Garnero P, "The type I collagen fragments ICTP and CTX reveal distinct enzymatic pathways of bone collagen degradation", J Bone Miner Res, 18, pp.859~867 (2003)[DOI]
