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피부각질세포 HaCaT에서 진세노사이드 Rg5에 의한 JAK/STAT 억제기전

JAK/STAT Inhibition Mechanism by Ginsenoside Rg5 in Keratinocyte HaCaT Cells

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초록

본 연구로 진세노사이드 Rg5에 의한 JAK/STAT 신호전달 경로의 활성 억제는 IL6R와 JAK3의 활성 억제로 나타났으며, 이를 통한 각종 염증성 질환 및 암의 유발을 억제하는 것으로 생각된다.

Abstract

The effect and mechanism of action of ginsenoside Rg5 was analyzed from the expression pattern of HaCaT in human dermal keratinocyte treated with miner ginsenoside Rg5 of Panax ginseng C. A. Meyer. The genes related to cell division, DNA repair, cell-cell adhesion, and cellular response to DNA damage stimulus were found to be 2-fold upregulated genes in the HaCaT cells, whereas 2-fold down-regulated genes were genes involved in positive regulation of transcription from RNA polymerase II promoter, regulation of JAK/STAT cascade, and multicelluar organism development. Especially, the down-regulated activities of IL6R and JAK3, the key factors of the JAK/STAT signaling pathway, were verified by qRT-PCR. Therefore, ginsenoside Rg5 can inhibit the activity of the JAK/STAT signaling pathway by inhibiting the activities of IL6R and JAK3.

참고문헌 (29)

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