A Mini-review on Exercise, Humoral factors, and Senescent Satellite Cell
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Exercise has been established as a highly efficacious non-invasive intervention for elderly population with sarcopenia. Nevertheless, the adaptive capacity of skeletal muscle and its resident satellite cells to exercise-induced stimuli is attenuated with advancing age, necessitating the exploration of complementary therapeutic modalities. Recent studies using a parabiotic pairing model in skeletal muscle research have shown that the impaired state of muscle stem cells in aged or genetically induced muscle-wasting animal models can be significantly improved through blood sharing with healthy animal models. This finding suggests that the microenvironment created by constantly circulating blood can significantly influence the phenotypic changes of aged skeletal muscle cells, and that there are potent humoral factors in the blood that directly affect myofiber growth and degeneration. However, there are many scientific hurdles to overcome before it can be applied to clinical study. Therefore, this review aims to delve into prior studies examining humoral factors and satellite cell function and to propose suggestions for subsequent research endeavors.
Abstract
Exercise has been established as a highly efficacious non-invasive intervention for elderly population with sarcopenia. Nevertheless, the adaptive capacity of skeletal muscle and its resident satellite cells to exercise-induced stimuli is attenuated with advancing age, necessitating the exploration of complementary therapeutic modalities. Recent studies using a parabiotic pairing model in skeletal muscle research have shown that the impaired state of muscle stem cells in aged or genetically induced muscle-wasting animal models can be significantly improved through blood sharing with healthy animal models. This finding suggests that the microenvironment created by constantly circulating blood can significantly influence the phenotypic changes of aged skeletal muscle cells, and that there are potent humoral factors in the blood that directly affect myofiber growth and degeneration. However, there are many scientific hurdles to overcome before it can be applied to clinical study. Therefore, this review aims to delve into prior studies examining humoral factors and satellite cell function and to propose suggestions for subsequent research endeavors.
참고문헌 (25)
- Bechshøft, C. J. L., "Age and prior exercise in vivo determine the subsequent in vitro molecular profile of myoblasts and nonmyogenic cells derived from human skeletal muscle", Am J Physiol Cell Physiol, 316, pp.C898~912 (2019)
- Damas, F., "A review of resistance traininginduced changes in skeletal muscle protein synthesis and their contribution to hypertrophy", Sports Med, 45, pp.801~807 (2015)
- Dumont, N. A., "Satellite Cells and Skeletal Muscle Regeneration", Compr Physiol, 5, pp.1027~1059 (2015)
- Hanna, L., "Association between skeletal muscle mass and quality of life in adults with cancer : a systematic review and meta-analysis", J Cachexia Sarcopenia Muscle, 13, pp.839~857 (2022)
- Fang, J., "Skeletal muscle regeneration via the chemical induction and expansion of myogenic stem cells in situ or in vitro", Nat Biomed Eng, 5, pp.864~879 (2021)
- Petermann-Rocha, F., "Global prevalence of sarcopenia and severe sarcopenia : a systematic review and meta-analysis", J Cachexia Sarcopenia Muscle, 13, pp.86~99 (2021)
- Fukada, S. I., "Role of damage and management in muscle hypertrophy : Different behaviors of muscle stem cells in regeneration and hypertrophy", Biochim Biophys Acta Mol Cell Res, 1867(9), pp.118742~ (2020)
- Görgens, S. W., "Exercise and Regulation of Adipokine and Myokine Production", Prog Mol Biol Transl Sci, 135, pp.313~336 (2015)
- Huo, F., "Contribution of muscle satellite cells to sarcopenia", Front Physiol, 12(13), pp.892749~ (2022)
- Hurst, C., "Resistance exercise as a treatment for sarcopenia : prescription and delivery", Age Ageing, 51(2), pp.afac003~ (2022)
- Shen, Y., "Exercise for sarcopenia in older people : A systematic review and network meta-analysis", J Cachexia Sarcopenia Muscle, 14, pp.1199~1211 (2023)
- Tournadre, A., "Sarcopenia", Joint Bone Spine, 86, pp.309~314 (2019)
- Larsson, L., "Sarcopenia : Aging-Related Loss of Muscle Mass and Function", Physiol Rev, 99, pp.427~511 (2019)
- Li, H., "Improved Bone Quality and Bone Healing of Dystrophic Mice by Parabiosis", Metabolites, 11(4), pp.247~ (2021)
- Liu, L., "A Review of IGF1 Signaling and IGF1-related Long Noncoding RNAs in Chemoresistance of Cancer", Curr Cancer Drug Targets, 20, pp.325~334 (2020)
- Lu, A., "Heterogenetic parabiosis between healthy and dystrophic mice improve the histopathology in muscular dystrophy", Sci Rep, 10(1), pp.7075~ (2020)
- Ma, X., "Blood-Derived alpha-Synuclein Aggregated in the Substantia Nigra of Parabiotic Mice", Biomolecules, 11(9), pp.1287~ (2021)
- Picca, A., "Molecular Mechanism and Pathogenesis of Sarcopenia: An Overview", Int J Mol Sci, 22(6), pp.3032~ (2021)
- Schiaffino, S., "Molecular Mechanisms of Skeletal Muscle Hypertrophy", J Neuromuscul Dis, 8, pp.169~183 (2021)
- Severinsen, M. C. K., "Muscle-Organ Crosstalk : The Emerging Roles of Myokines", Endocr Rev, 41, pp.594~609 (2020)
- Sinha, I., "Testosterone is essential for skeletal muscle growth in aged mice in a heterochronic parabiosis model", Cell Tissue Res, 357, pp.815~821 (2014)
- Snijders, T., "The impact of sarcopenia and exercise training on skeletal muscle satellite cells", Ageing Res Rev, 8, pp.328~338 (2009)
- Werner, H., "Role of the GHIGF1system in progression of cancer", Mol Cell Endocrinol, 1, pp.518~ (2020)
- Whitham, M., "The everexpanding myokinome : discovery challenges and therapeutic implications", Nat Rev Drug Discov, 15, pp.719~729 (2016)
- Zhang, L., "Satellite cell dysfunction and impaired IGF-1 signaling cause CKD-induced muscle atrophy", J Am Soc Nephrol, 21, pp.419~427 (2010)