전장유전체 관련성 분석을 통한 순종 랜드레이스 생시체중 형질의 위치상 후보유전자 탐색
Genome-wide Association Study Identifies Positional Candidate Genes Affecting Birth Weight Trait in Purebred Landrace
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초록
돼지의 생시체중은 생존율과 폐사율에 밀접한 관련이 있어 양돈산업에서 자돈 관리와 직결된 중요한경제형질이다. 본 연구는 Genome-Wide Association Study(GWAS) 분석을 통해 순종 랜드레이스의 생시체중과 관련된 위치상 후보유전자 탐색을 실시하였다. 생시체중의 유의적 관련 분석 결과, genomewidesuggestive level에서 유의성 있는 single nucleotide polymorphism(SNP) marker는 3번 염색체(ASGA0098921, P=2.41×10-5)와 4번 염색체(H3GA0013451, P=2.47×10-5)에서 각각 1개씩 동정되었다. 이들 SNP marker가 위치한 3개의 유전자(LOC110260055, LOC100156472, LOC100157689)들은 순종 랜드레이스 생시체중의 위치상 후보 유전자이며, 이들 유전자 정보를 이용해서 순종 랜드레이스 생시체중을 선발할 수 있는 기초 연구 자료가 될 것으로 사료된다.
Abstract
Birth weight represents an important trait that has an economic value because it is closelyassociated with survival and mortality. This study aimed to identify positional candidate genesassociated with birth weight of purebred Landrace pigs using genome-wide associationstudy(GWAS). Based on the analysis of genes significantly associated with birth weight, a singlenucleotide polymorphism(SNP) marker that is significant at genome-wide suggestive level wasidentified on chromosome 3(ASGA0098921, P=2.41×10-5) and 4(H3GA0013451, P=2.47×10-5),respectively. These three genes(LOC110260055, LOC100156472, LOC100157689) containing eachSNP marker individually are positional candidate genes associated with birth weight of purebredLandrace pigs. Therefore, the results of this study can be used for fundamental studies requiredto select an optimal birth weight range for the purebred Landrace pigs.
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