전장유전체 관련성 분석을 통한 돼지 도체중 형질의 위치상 후보유전자 탐색
Genome-wide Association Study Identifies Positional Candidate Genes Affecting Carcass Weight Trait in Pigs
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초록
양돈산업에서 돼지의 성장형질은 수익성과 직결된 중요한 경제 형질이며, 대표적인 형질로는 일당증체량, 등지방두께, 도체중 등이 있다. 본 연구는 Genome-Wide Association Study(GWAS) 분석을 통해 돼지 도체중과 관련성 있는 위치상 후보유전자를 chromosome-wide 임계치에서 탐색하였다. 도체중과의 관련성 분석 결과, 염색체 수준에서 유의성 있는 single nucleotide polymorphism(SNP) 표지들은 2번 염색체에서 1개(ALGA0015365), 4번 염색체에서 1개의 SNP 마커(ALGA0023678)가 동정되었다. 이들 SNP 마커와 가까이 위치한 2개의 유전자(LOC100519538, LOC100737583)들은 돼지 성장형질중 도체중의 위치상 후보 유전자로서, 이들 유전자 변이 정보를 이용해서 돼지 도체중을 선발할 수 있는 기초연구 자료가 될 수 있을 것이다.
Abstract
In the swine industry, growth related traits are important economic traits directly linked toprofitability. Representative growth traits include daily gain, back fat thickness, and carcassweight. This study was conducted to search for positional candidate genes associated with thecarcass weight through a genome-wide association study(GWAS) using suggestive levels ofstatistical thresholds in pigs. As a result of the genome-wide analysis of the associations withcarcass weight, the single nucleotide polymorphism(SNP) markers with suggestive significancewere identified in 1 SNP marker on chromosome 2(ALGA0015365) and 1 SNP marker onchromosome 4(ALGA0023678). We could select positional 2 candidate genes, located close tothe SNP markers with suggestive significance levels. The SNP markers in adjacent to the 2genes(LOC100519538, LOC100737583) may provide basic data regarding the marker-assistedselection for the carcass weight trait in pigs.
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