Predicted Value of Serum Transaminase, Pyruvate Kinase and Lactate Dehydrogenase Levels in Patient with Duchenne Muscular Dystrophy in South Korea
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Objective: Serum concentrations of transaminase, pyruvate kinase (PK), and lactate dehydrogenase (LDH) are considered biochemical indicators of Duchenne muscular dystrophy (DMD), but they can also detect hepatocellular injury. This study was designed to develop mathematical models that predict serum concentrations of these hepatic marker enzymes in Korean patients with DMD, based on their age and serum concentrations of creatine kinase (CK) and CK MB isoenzyme (CKMB). Method: Boys with genetically confirmed DMD were identified retrospectively; all were normal for hepatic viral markers or on abdominal ultrasonography. Serum concentrations of CK, CKMB, transaminase, PK, and LDH were measured, and statistical analyses were performed to determine whether transaminase, PK, and LDH levels were related to age and serum CK and CKMB levels. Results: The study included a total of 134 patients with DMD. Serum transaminase, PK, and LDH levels were linearly related to patient age and serum CK and CKMB levels. A mathematical model was developed, in which patient age and serum CK and CKMB concentrations can predict mean transaminase, PK, and LDH concentrations. Conclusion: This mathematical model may provide some reassurance to DMD patients with high serum concentrations of hepatic marker enzymes and prevent unnecessary procedures to exclude hepatic dysfunction.
Abstract
Objective: Serum concentrations of transaminase, pyruvate kinase (PK), and lactate dehydrogenase (LDH) are considered biochemical indicators of Duchenne muscular dystrophy (DMD), but they can also detect hepatocellular injury. This study was designed to develop mathematical models that predict serum concentrations of these hepatic marker enzymes in Korean patients with DMD, based on their age and serum concentrations of creatine kinase (CK) and CK MB isoenzyme (CKMB). Method: Boys with genetically confirmed DMD were identified retrospectively; all were normal for hepatic viral markers or on abdominal ultrasonography. Serum concentrations of CK, CKMB, transaminase, PK, and LDH were measured, and statistical analyses were performed to determine whether transaminase, PK, and LDH levels were related to age and serum CK and CKMB levels. Results: The study included a total of 134 patients with DMD. Serum transaminase, PK, and LDH levels were linearly related to patient age and serum CK and CKMB levels. A mathematical model was developed, in which patient age and serum CK and CKMB concentrations can predict mean transaminase, PK, and LDH concentrations. Conclusion: This mathematical model may provide some reassurance to DMD patients with high serum concentrations of hepatic marker enzymes and prevent unnecessary procedures to exclude hepatic dysfunction.
참고문헌 (17)
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