Analysis of Pulmonary Function Test in Korean Patients With Duchenne Muscular Dystrophy: Comparison of Foreign and Korean Reference Data
4
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Objective To determine the abnormal pulmonary function value in Korean Duchenne muscular dystrophy (DMD) patients, we performed a comparative analysis of the patients’ pulmonary function value expressed as % of the overseas reference data and Korean healthy children and adolescent reference data.Methods We performed pulmonary function test (PFT) in a total of 27 DMD patients. We compared the patients’ FVC% and FEV1% of the overseas reference data with those of the Korean children and adolescent reference data. Also, we compared the patients’ MIP% and MEP% of the prediction equation data with those of the Korean children and adolescent reference data. Results Age of the subjects ranged from 8 to 16 years (12.03±2.27 years). The mean maximal expiratory pressure (MEP), maximal inspiratory pressure (MIP), vital capacity (VC), forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), and peak cough flow (PCF) were 36.93±9.5 cmH2O, 45.79±17.46 cmH2O, 1.4±0.43 L, 1.45±0.45 L, 1.40±0.41 L, and 206.25±61.21 L/min, respectively. The MIP%, MEP%, and FVC% of the Korean children and adolescent reference data showed statistically significant higher values than those of the prediction equation data.Conclusion We observed a clear numeric difference between Korean DMD patients’ pulmonary function value expressed as % of the overseas data and inland data. To perform a precise assessment of respiratory function and to determine appropriate respiratory therapy, pulmonary function values of Korean DMD patients should be interpreted taking into account the inland normal pulmonary function test data.
Abstract
Objective To determine the abnormal pulmonary function value in Korean Duchenne muscular dystrophy (DMD) patients, we performed a comparative analysis of the patients’ pulmonary function value expressed as % of the overseas reference data and Korean healthy children and adolescent reference data.Methods We performed pulmonary function test (PFT) in a total of 27 DMD patients. We compared the patients’ FVC% and FEV1% of the overseas reference data with those of the Korean children and adolescent reference data. Also, we compared the patients’ MIP% and MEP% of the prediction equation data with those of the Korean children and adolescent reference data. Results Age of the subjects ranged from 8 to 16 years (12.03±2.27 years). The mean maximal expiratory pressure (MEP), maximal inspiratory pressure (MIP), vital capacity (VC), forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), and peak cough flow (PCF) were 36.93±9.5 cmH2O, 45.79±17.46 cmH2O, 1.4±0.43 L, 1.45±0.45 L, 1.40±0.41 L, and 206.25±61.21 L/min, respectively. The MIP%, MEP%, and FVC% of the Korean children and adolescent reference data showed statistically significant higher values than those of the prediction equation data.Conclusion We observed a clear numeric difference between Korean DMD patients’ pulmonary function value expressed as % of the overseas data and inland data. To perform a precise assessment of respiratory function and to determine appropriate respiratory therapy, pulmonary function values of Korean DMD patients should be interpreted taking into account the inland normal pulmonary function test data.
참고문헌 (27)
- Walton JN, "Disorders of voluntary muscle", pp.561~613 (1974), Churchill Livingston
- Gardner-Medwin D, "Clinical features and classification of the muscular dystrophies", Br Med Bull, 36, pp.109~115 (1980)
- Hapke EJ, "Pulmonary function in progressive muscular dystrophy", Chest, 61, pp.41~47 (1972)
- Inkley SR, "Pulmonary function in Duchenne muscular dystrophy related to stage of disease", Am J Med, 56, pp.297~306 (1974)
- Rideau Y, "Prognosis of progressive muscular dystrophy in children. Analysis of early and exact criteria", Union Med Can, 106, pp.874~882 (1977)
- Rideau Y, "Respiratory function in the muscular dystrophies", Muscle Nerve, 4, pp.155~164 (1981)
- Nagai T, "Prognostic evaluation of congestive heart failure in patients with Duchenne muscular dystrophy:retrospective study using non-invasive cardiac function tests", Jpn Circ J, 53, pp.406~415 (1989)
- McDonald CM, "Profiles of neuromuscular diseases. Duchenne muscular dystrophy", Am J Phys Med Rehabil, 74(5 Suppl), pp.S70~S92 (1995)
- Black LF, "Maximal respiratory pressures:normal values and relationship to age and sex", Am Rev Respir Dis, 99, pp.696~702 (1969)
- Gayraud J, "Ventilatory parameters and maximal respiratory pressure changes with age in Duchenne muscular dystrophy patients", Pediatr Pulmonol, 45, pp.552~559 (2010)
- Arora NS, "Respiratory muscle strength and maximal voluntary ventilation in undernourished patients", Am Rev Respir Dis, 126, pp.5~8 (1982)
- Celli BR, "Clinical and physiologic evaluation of respiratory muscle function", Clin Chest Med, 10, pp.199~214 (1989)
- Enright PL, "Respiratory muscle strength in the elderly:correlates and reference values. Cardiovascular Health Study Research Group", Am J Respir Crit Care Med, 149(2 Pt 1), pp.430~438 (1994)
- Hautmann H, "Maximal inspiratory mouth pressures (PIMAX) in healthy subjects: what is the lower limit of normal?", Respir Med, 94, pp.689~693 (2000)
- Arnall DA, "Maximal respiratory pressure reference values for Navajo children ages 6-14", Pediatr Pulmonol, 48, pp.804~808 (2013)
- Wilson SH, "Predicted normal values for maximal respiratory pressures in caucasian adults and children", Thorax, 39, pp.535~538 (1984)
- Tomalak W, "Normal values for maximal static inspiratory and expiratory pressures in healthy children", Pediatr Pulmonol, 34, pp.42~46 (2002)
- Yoon KA, "Normal predicted values of pulmonary function test in Korean schoolaged children", J Korean Pediatr Soc, 36, pp.25~37 (1993)
- Hahn A, "Clinical implications of maximal respiratory pressure determinations for individuals with Duchenne muscular dystrophy", Arch Phys Med Rehabil, 78, pp.1~6 (1997)
- Bye PT, "Respiratory failure and sleep in neuromuscular disease", Thorax, 45, pp.241~247 (1990)
- Griggs RC, "Evaluation of pulmonary function in neuromuscular disease", Arch Neurol, 38, pp.9~12 (1981)
- 강성웅, "Respiratory Muscle Strength and Cough Capacity in Patients with Duchenne Muscular Dystrophy", Yonsei Medical Journal, 47(2), pp.184~190 (2006), 연세대학교의과대학
- Lissoni A, "Assessment of the respiratory function in individuals with Duchenne muscular dystrophy", Eura Medicophys, 37, pp.71~81 (2001)
- Bushby K, "Diagnosis and management of Duchenne muscular dystrophy. Part 2: implementation of multidisciplinary care", Lancet Neurol, 9, pp.177~189 (2010)
- Phillips MF, "Changes in spirometry over time as a prognostic marker in patients with Duchenne muscular dystrophy", Am J Respir Crit Care Med, 164, pp.2191~2194 (2001)
- Gomez-Merino E, "Duchenne muscular dystrophy:prolongation of life by noninvasive ventilation and mechanically assisted coughing", Am J Phys Med Rehabil, 81, pp.411~415 (2002)
- Eagle M, "Survival in Duchenne muscular dystrophy: improvements in life expectancy since 1967 and the impact of home nocturnal ventilation", Neuromuscul Disord, 12, pp.926~929 (2002)