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Diagnosis and Characterization of Middle-ear and Cochlear Functions

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초록

Hearing impairment is one of the most common physical disabilities in the world. Conductive hearing loss results from dysfunction of the middle ear, and sensorineural hearing loss results from abnormalities within the cochlea or central nervous system. To improve the diagnosis of hearing loss and develop new technologies for restoration of hearing, changes of the middle ear and cochlear functions in relation to ear structural disorders in hearing impaired ears need to be characterized. This paper summarizes our biomedical engineering approach to characterize the middle ear and cochlear functions in normal and diseased ears. With the experimental measurements in human temporal bones and animal models and the finite element (FE) modeling of the human ear, a better understanding of biomechanics of the ear for sound transmission is achieved. The acoustic-mechanical vibration and energy transmission through the middle ear in normal and diseased ears can be visualized and quantified in a 3-dimensional FE model. Four novel model-derived “auditory test curves” named as the middle ear transfer function, energy absorbance, admittance tympanogram, and tympanic membrane holography are generated with clinically relevant applications.

Abstract

Hearing impairment is one of the most common physical disabilities in the world. Conductive hearing loss results from dysfunction of the middle ear, and sensorineural hearing loss results from abnormalities within the cochlea or central nervous system. To improve the diagnosis of hearing loss and develop new technologies for restoration of hearing, changes of the middle ear and cochlear functions in relation to ear structural disorders in hearing impaired ears need to be characterized. This paper summarizes our biomedical engineering approach to characterize the middle ear and cochlear functions in normal and diseased ears. With the experimental measurements in human temporal bones and animal models and the finite element (FE) modeling of the human ear, a better understanding of biomechanics of the ear for sound transmission is achieved. The acoustic-mechanical vibration and energy transmission through the middle ear in normal and diseased ears can be visualized and quantified in a 3-dimensional FE model. Four novel model-derived “auditory test curves” named as the middle ear transfer function, energy absorbance, admittance tympanogram, and tympanic membrane holography are generated with clinically relevant applications.

참고문헌 (80)

  1. Aibara, R., "Human middle-ear sound transfer function and cochlear impedance", Hearing Research, 152, pp.100~109 (2001)
  2. Cheng, T., "Viscoelastic properties of human tympanic membrane", Annals of Biomedical Engineering, 35(2), pp.305~314 (2007)
  3. Cheng, T., "Mechanical properties of stapedial tendon in human middle ear", Journal of Biomechanical Engineering, 129, pp.913~918 (2007)
  4. Cheng, T., "Experimental measurement and modeling analysis on mechanical properties of tensor tympani tendon", Medical Engineering and Physics, 30, pp.358~366 (2008)
  5. Cheng, T., "Mechanical properties of anterior malleolar ligament from experimental measurement and material modeling analysis", Biomechanics and Modeling in Mechanobiology, 7, pp.387~394 (2008)
  6. Dai, C., "Tympanometry and laser doppler interferometry measurements on otitis media with effusion model in human temporal bones", Otology and Neurotology, 28(4), pp.551~558 (2007)
  7. Dai, C., "Detachment and fixation of superior and anterior malleus ligament: Experiment and modeling", Hearing Research, 230(1-2), pp.24~33 (2007)
  8. Dai, C., "Combined effect of fluid and pressure on middle ear function", Hearing Research, 236(1-2), pp.22~32 (2008)
  9. Dai, C., "Change of middle ear transfer function in otitis media with effusion model of guinea pigs", Hearing Research, 243, pp.78~86 (2008)
  10. Dai, C., "Change in cochlear response in an animal model of otitis media with effusion", Audiology and Neurotology, 15, pp.155~167 (2010)
  11. Daphalapurkar, N. P., "Characterization of the linearly viscoelastic behavior of human tympanic membrane using nanoindentation technique", Journal of the Mechanical Behavior of Biomedical Materials, 2, pp.82~92 (2009)
  12. Dirckx, J. J. J., "Area change and volume displacement of the human tympanic membrane under static pressure", Hearing Research, 62, pp.99~104 (1992)
  13. Dirks, D. D., "Tympanometry and acoustic reflex testing, In The ear: Comprehensive Otology", pp.223~229 (2000), Lipponcott Williams & Wilkins
  14. Feeney, M. P., "Wideband energy reflectance measurements in adults with middle-ear disorders", Journal of Speech Language and Hearing Research, 46, pp.901~911 (2003)
  15. Feeney, M. P., "Wideband energy reflectance measurements of ossicular chain discontinuity and repair in human temporal bone", Ear and Hearing, 30, pp.391~400 (2009)
  16. Feng, B., "Lumped parametric model of human ear for sound transmission", Biomechanics and Modeling in Mechanobiology, 3, pp.33~47 (2004)
  17. Gan, R. Z., "Implantable hearing device performance measured by laser Doppler interferometer", ENT-Ear, Nose and Throat Journal, 76(5), pp.297~309 (1997)
  18. Gan, R. Z., "Mass loading on ossicles and middle ear function", Annals of Otology, Rhinology, and Laryngology, 110, pp.478~585 (2001)
  19. Gan, R. Z., "Three dimensional modeling of middle ear biomechanics and its application", Otology and Neurotology, 23(3), pp.271~280 (2002)
  20. Gan, R. Z., "Human middle ear transfer function measured by double laser interferometry system", Otology and Neurotology, 25(4), pp.423~435 (2004)
  21. Gan, R. Z., "Threedimensional finite element modeling of human ear for sound transmission", Annals of Biomedical Engineering, 32, pp.847~859 (2004)
  22. Gan, R. Z., "Laser interferometry measurements of middle ear fluid and pressure effects on sound transmission", Journal of the Acoustical Society of America, 120(6), pp.3799~3810 (2006)
  23. Gan, R. Z., , Medical Engineering and Physics, 28, pp.395~404 (2006)
  24. Gan, R. Z., "Multi-field finite element analysis for sound transmission in otitis with effusion", Journal of the Acoustical Society of America, 122(6), pp.3527~3538 (2007)
  25. Gan, R. Z., "Modeling of sound transmission from ear canal to cochlea", Annals of Biomedical Engineering, 35(12), pp.2180~2195 (2007)
  26. Gan, R. Z., "Finite element modeling of sound transmission with perforations of tympanic membrane", Journal of the Acoustical Society of America, 126(1), pp.243~253 (2009)
  27. Gan, R. Z., "A totally implantable hearing system–design and function characterization in 3D computational model and temporal bones", Hearing Research, 263, pp.138~144 (2010)
  28. Gan, R. Z., "Mechanical properties of human stapedial annular ligament", Medical Engineering and Physics, 33, pp.330~339 (2011)
  29. Gan, R. Z., "Dynamic properties of round window membrane in guinea pig otitis media model", Hearing Research, 301, pp.125~136 (2013)
  30. Gan, R. Z., "Novel auditory test curves derived from 3D finite element models of human ear", ARO - Midwinter Meeting, 37 (2013)
  31. Goode, R. L., "New knowledge about the function of the human middle ear: Development of an improved analog model", American Journal of Otology, 15, pp.145~154 (1994)
  32. Guan, X., "Effect of middle ear fluid on sound transmission and auditory brainstem response in guinea pigs", Hearing Research, 277, pp.96~106 (2011)
  33. Guan, X., "Mechanisms of tympanic membrane mobility loss in acute otitis media model of guinea pig", Journal of the Association for Research in Otolaryngology, 14, pp.295~307 (2013)
  34. Guan, X., "Comparison of eardrum mobility in acute otitis media and otitis media with effusion models", Otology and Neurotology, 34(7), pp.1316~1320 (2013)
  35. Guan, X., "Factors affecting loss of tympanic membrane mobility in acute otitis media model of chinchillas", Hearing Research (Under Review) (2013)
  36. Gould, J. M., "Otitis media", Pediatrics in Review, 31, pp.102~110 (2010)
  37. Gyo, K., "Measurement of the ossicular vibration ratio in human temporal bones by use of a video measuring system", Acta Oto-Laryngologica, 103, pp.87~95 (1987)
  38. Hato, N., "Threedimensional stapes footplate motion in human temporal bones", Audiology and Neurotology, 8, pp.140~152 (2003)
  39. Hudde, H., "A threedimensional circuit model of the middle ear", Acta Acustica United with Acustica, 83(3), pp.535~549 (1997)
  40. Huang, G., "Measurement of linear viscoelastic properties of human tympanic membrane using nanoindentation", Journal of Biomechanical Engineering, 130, pp.014501- 1~014501- 7 (2008)
  41. Ji, X. D., "Development of auditory test modeling system (ATMS) software based on 3D finite element model of human ear", Proceedings from BMES 2013 Annual Meeting (2013)
  42. Keefe, D. H., "Ear-canal impedance and reflection coefficient in human infants and adults", Journal of the Acoustical Society of America, 94, pp.2617~2638 (1993)
  43. Keefe, D. H., "Energy transmittance predicts conductive hearing loss in older children and adults", Journal of the Acoustical Society of America, 114, pp.3217~3238 (2003)
  44. Koike, T., "Modeling of the human middle ear using the finite-element method", Journal of the Acoustical Society of America, 111(3), pp.1306~1317 (2002)
  45. Kringlebotn, M., "Frequency characteristics of the middle ear", Journal of the Acoustical Society of America, 77, pp.159~164 (1985)
  46. Kringlebotn, M., "Network model for the human middle ear", Scandinavian Audiology, 17, pp.75~85 (1988)
  47. Larsson, C., "Pars flaccida displacement pattern in otitis media with effusion in the gerbil", Otology and Neurotology, 26(3), pp.337~343 (2005)
  48. Lee, C. F., "Three-dimensional reconstruction and modeling of middle ear biomechanics by high-resolution computed tomography and finite element analysis", Laryngoscope, 116(5), pp.711~716 (2006)
  49. Lee, C-Y., "Effects of middle-ear static pressure on pars tensa and pars flaccida of gerbil ears", Hearing Research, 153, pp.146~163 (2001)
  50. Luo, H., "Measurement of Young’s modulus of human tympanic membrane at high strain rates", Journal of Biomechanical Engineering, 131, pp.064501-1~064501-8 (2009)
  51. Luo, H., "A comparison of Young’s modulus for normal and diseased human eardrums at high strain rates", International Journal of Experimental and Computational Biomechanics, 1(1), pp.1~22 (2009)
  52. Margolis, R. H., "Wideband reflectance tympanometry in normal adults", Journal of the Acoustical Society of America, 106, pp.265~280 (1999)
  53. Merchant, S. N., "Analysis of middle ear mechanics and application to diseased and reconstructed ears", American Journal of Otology, 18(2), pp.139~154 (1997)
  54. Murakami, S., "Effect of middle ear pressure change on middle ear mechanics", Acta Oto-laryngologica, 117, pp.390~395 (1997)
  55. Nuttall, A. L., "Steady-state sinusoidal velocity responses of the basilar membrane in guinea pig", Journal of the Acoustical Society of America, 99, pp.1556~1565 (1996)
  56. Peake, W. T., "Middle-ear transmission: Acoustic versus ossicular coupling in cat and human", Hearing Research, 57, pp.245~268 (1992)
  57. Qi, L., "A nonlinear finite-element model of the newborn middle ear", Journal of the Acoustical Society of America, 124(1), pp.337~347 (2008)
  58. Qin, Z., "Measurement of conductive hearing loss in mice", Hearing Research, 263, pp.93~103 (2010)
  59. Ravicz, M. E., "Mechanisms of hearing loss resulting from middle-ear fluid", Hearing Research, 195(1-2), pp.103~130 (2004)
  60. Rabinowitz, W. M., "Measurement of the acoustic input immittance of the human ear", Journal of the Acoustical Society of America, 70, pp.1025~1035 (1981)
  61. Rosowski, J. J., "The effect of immobilizing the gerbil’s pars flaccida on the middle-ear’s response to static pressure", Hearing Research, 174, pp.183~195 (2002)
  62. Stepp, C. E., "Acoustics of the human middle-ear air space", Journal of the Acoustical Society of America, 118, pp.861~871 (2005)
  63. Sun, Q., "Computer-integrated finite element modeling of human middle ear", Biomechanical Modeling in Mechanobiology, 1, pp.109~122 (2002)
  64. Sun, Q., "An advanced computer -aided geometric modeling and fabrication method for human middle ear", Medical Engineering and Physics, 24, pp.596~606 (2002)
  65. Turcanu, D., "Accuracy of velocity distortion product otoacoustic emissions for estimating mechanically based hearing loss", Hearing Research, 251, pp.17~28 (2009)
  66. Von Unge, M., "Shape and displacement patterns of the gerbil tympanic membrane in experimental otitis media with effusion", Hearing Research, 82(2), pp.184~196 (1995)
  67. Voss, S. E., "Measurement of acoustic impedance and reflectance in the human ear canal", Journal of the Acoustical Society of America, 95, pp.372~384 (1994)
  68. Voss, S. E., "Acoustic responses of the human ear", Hearing Research, 150, pp.43~69 (2000)
  69. Wang, X., "Finite element analysis of middle ear pressure effects on static and dynamic behavior of human ear", Journal of the Acoustical Society of America, 122(2), pp.906~917 (2007)
  70. Zhang, X., "Dynamic properties of human tympanic membrane - Experimental measurement and modeling analysis", International Journal of Experimental and Computational Biomechanics, 1(3), pp.252~270 (2010)
  71. Zhang, X., "A comprehensive model of human ear for analysis of implantable hearing devices", IEEE Transations on Biomedical Engineering, 58(10), pp.3024~3027 (2011)
  72. Zhang, X., "Experimental measurement and modeling analysis on mechanical properties of incudostapedial joint", Biomechanics Modeling in Mechanobiology, 10, pp.713~726 (2011)
  73. Zhang, X., "A finite element model of pediatric ear for sound transmission from ear canal to middle ear", ARO - Midwinter Meeting, 35, pp.31~ (2012)
  74. Zhang, X., "Computational modeling of otitis media in pediatric ear", Proceedings BMES Annual Meeting (2012)
  75. Zhang, X., "Finite element modeling of energy absorbance in normal and disordered human ear", Hearing Research, 301, pp.146~155 (2013)
  76. Zhang, X., "Dynamic properties of human tympanic membrane based on frequencytemperature superposition", Annals of Biomedical Engineering, 41(1), pp.205~214 (2013)
  77. Zhang, X., "Dynamic properties of human round window membrane in auditory frequencies", Medical Engineering and Physics, 35(3), pp.310~318 (2013)
  78. Zhang, X., "Imaging the human tympanic membrane motion using scanning laser Doppler vibrometer and finite element model", Journal of the Association for Research in Otolaryngology (Under Review) (2013)
  79. Zhao, F., "Finite element analysis of the middle ear transfer functions and related pathologies", Medical Engineering and Physics, 31(8), pp.907~916 (2009)
  80. Zwislocki, J., "Analysis of the middle ear function. Part I. Input impedance", Journal of the Acoustical Society of America, 34, pp.1514~1523 (1962)

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