브루셀라증 환자 3명에서 미생물학적,혈청학적 및 유전자 검사에 의한 진단적 경험
Diagnostic Experience in the 3 Human Brucellosis Cases by theMicrobiologic, Serologic and Gene Tests
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브루셀라증은 브루셀라속 균에 의해 감염되는 인수공통 전염병으로 B. melitenisis, B. susis, B. abortus, B. canis 등이 주로 인체감염을 일으킨다. 우리나라에서는 최근 소 브루셀라증이 매년 발생하고 있으며 2003년 인체 브루셀라증이 첫 보고 된 이래 축산업 종사자, 수의사 등의 특정 직업군에서 인체감염이 계속 증가하고 있다. 인체 브루셀라증은 임상양상이 매우 다양하고 비특이적이어서 진단이 지연되거나 놓칠 수 있다. 따라서 임상의사와 검사실에서는 고위험군 환자를 진단, 치료할 때 균배양이나 혈청학적 검사 등의 고식적인 진단 방법 외에 혈액내 브루셀라 유전자를 직접 검출할 수 있는 중합효소연쇄반응법 등의 적극적인 진단검사 및 검사실 감염을 예방하기 위한 조치가 필요하다. 저자들은 축산업에 종사하는 3명의 브루셀라증 환자의 혈액, 골수 및 혈청에서 균배양과 중합효소연쇄반응법을 시행하여 B. abortus 균을 검출 하였기에 보고하는 바이다.
Abstract
Brucellosis is a zoonosis caused by Brucella species. B. melitensis, B. suis, B. abortus and B. canis can infect humans. Recently, as the cases of bovine brucellosis have increased every year in Korea, the cases of human brucellosis have also increased among livestock workers and veterinarians in rural areas, since the first human case was reported in 2003. Because clinical manifestations of the disease are nonspecific and may be very atypical, clinicians and laboratory persons need to be active in using diagnostic tools including polymerase chain reaction in addition to the ordinary culture and serologic tests, and taking an appropriate measure to prevent intralaboratory infection. We report herein our experience in three human brucellosis cases diagnosed by cultures, serologic tests and gene detection.
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