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Serological diagnosis of tissue-invading parasites in Korea

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대한임상미생물학회 (Korean Society of Clinical Microbiology)|2024.06|Annals of Clinical Microbiology|제27권 제2호|pp. 81-91|DOI 10.5145/ACM.2024.27.2.5

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참고문헌

키워드

KoreaELISAKeywords: HelminthsSerological tests

초록

Although intestinal parasites are no longer considered a significant public health concernin Korea, tissue-invading parasites continue to pose clinical challenges. The diagnosisof tissue helminthiasis by recovering worms or larvae from tissues is invasive; therefore,serodiagnosis is widely used to diagnose infections caused by tissue-invading parasites. Among the serological tests, the enzyme-linked immunosorbent assay (ELISA) is the mostcommonly used, and various antigens, including crude antigens, excretory-secretoryantigens of helminths, and cystic fluid of larval tapeworms, are used to detect specific IgGsagainst parasite antigens in the sera or cerebrospinal fluid of patients. A multi-antigen ELISAwas used to diagnose four major tissue parasitic infections: clonorchiasis, paragonimiasis,cysticercosis, and sparganosis. In addition to these four parasitic infections, ELISA remainsa valuable diagnostic method for toxocariasis, trichinellosis, fascioliasis, echinococcosis,and other diseases. A comprehensive history of the mode of transmission of the suspectedparasites and the patient’s residence in or travel to an endemic area may help in making adefinitive diagnosis. For the management of patients with eosinophilia in Korea, it is essentialto perform ELISA for the differential diagnosis of toxocariasis. Serological tests have thedisadvantage of being unable to differentiate between past and current infections, and thepossibility of cross-reactivity requires careful interpretation. It is important to note that theresults of serological tests are not necessarily conclusive and should be interpreted in thecontext of other symptoms, as well as clinical and imaging findings.

Abstract

Although intestinal parasites are no longer considered a significant public health concernin Korea, tissue-invading parasites continue to pose clinical challenges. The diagnosisof tissue helminthiasis by recovering worms or larvae from tissues is invasive; therefore,serodiagnosis is widely used to diagnose infections caused by tissue-invading parasites. Among the serological tests, the enzyme-linked immunosorbent assay (ELISA) is the mostcommonly used, and various antigens, including crude antigens, excretory-secretoryantigens of helminths, and cystic fluid of larval tapeworms, are used to detect specific IgGsagainst parasite antigens in the sera or cerebrospinal fluid of patients. A multi-antigen ELISAwas used to diagnose four major tissue parasitic infections: clonorchiasis, paragonimiasis,cysticercosis, and sparganosis. In addition to these four parasitic infections, ELISA remainsa valuable diagnostic method for toxocariasis, trichinellosis, fascioliasis, echinococcosis,and other diseases. A comprehensive history of the mode of transmission of the suspectedparasites and the patient’s residence in or travel to an endemic area may help in making adefinitive diagnosis. For the management of patients with eosinophilia in Korea, it is essentialto perform ELISA for the differential diagnosis of toxocariasis. Serological tests have thedisadvantage of being unable to differentiate between past and current infections, and thepossibility of cross-reactivity requires careful interpretation. It is important to note that theresults of serological tests are not necessarily conclusive and should be interpreted in thecontext of other symptoms, as well as clinical and imaging findings.

참고문헌 (57)

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관련 논문AI추천

Serodiagnosis of Echinococcosis by ELISA Using Cystic Fluid from Uzbekistan Sheep홍사민, 홍성태, Abdukhakim Khajibaev, JIN YAN, Khikmat Anvarov대한기생충학ㆍ열대의학회 · Parasites, Hosts and Diseases2013 · 제51권 제3호Serodiagnosis of Toxocariasis by ELISA Using Crude Antigen of Toxocara canis Larvae홍성태, Yan Jin대한기생충학ㆍ열대의학회 · Parasites, Hosts and Diseases2013 · 제51권 제4호Comparison of Two Enzyme-Linked Immunosorbent Assays forDetecting Parasitic Diseases김혜련, 이미경, 채종일, 홍성태대한임상미생물학회 · Annals of Clinical Microbiology2008 · 제11권 제1호Infection Status of Endoparasites in Foreigner Workers Living in Cheonan City, Chungnam Province, KoreaHae-Seon Nam, Joo-Yeon Oh, Mi-Jung Ahn, Min Seo, Suk-Yul Jung, Sung-Tae Hong, Yeon-Han Yun대한기생충학ㆍ열대의학회 · Parasites, Hosts and Diseases2015 · 제53권 제2호Seroprevalence of Toxocariasis among Healthy People with Eosinophilia허선, 김용헌, 정영배대한기생충학ㆍ열대의학회 · Parasites, Hosts and Diseases2008 · 제46권 제1호Excretory-secretory antigen is better than crude antigen for the serodiagnosis of clonorchiasis by ELISA이순옥, 최민호, 홍성태대한기생충학ㆍ열대의학회 · Parasites, Hosts and Diseases2003 · 제41권 제1호

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