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Protective effect of Tranilast on radiation-induced heart fibrosis in C57BL/6 mouse

문성권
한국콘텐츠학회 (The Korea Contents Association)|2012.12|International Journal of Contents|제8권 제4호|pp. 63-68|DOI http://dx.doi.org/10.5392/IJoC.2012.8.4.063

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참고문헌

키워드

RadiationHeart FibrosisTranilast
주제분류컴퓨터학

초록

The heart is a major dose‐limiting organ for radiotherapy of cancer in the thoracic region. The purpose of this study was to examine the protective effect of tranilast on the radiation‐induced heart fibrosis model using the C57BL/6 murine strain. A significant reduction in the expression of TGF‐β1, collagen type Ⅰ and collagen type Ⅲ was observed in the radiation plus tranilast group. The authors also suggest the use of tranilast in a clinical trial for the prevention of radiation-induced heart fibrosis.

Abstract

The heart is a major dose‐limiting organ for radiotherapy of cancer in the thoracic region. The purpose of this study was to examine the protective effect of tranilast on the radiation‐induced heart fibrosis model using the C57BL/6 murine strain. A significant reduction in the expression of TGF‐β1, collagen type Ⅰ and collagen type Ⅲ was observed in the radiation plus tranilast group. The authors also suggest the use of tranilast in a clinical trial for the prevention of radiation-induced heart fibrosis.

참고문헌 (21)

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