축산식품 중 비스테로이드성 항염증 약물의 잔류함량 모니터링
Mornitoring of non-steroidal anti-inflammatory drugs in livestock products
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This study was conducted to determine the content of non-steroidal anti-inflammatory drugs(NSAIDs) in meats available on the Korean markets. The analysis was carried out using following conditions; C18 column(100×2.1 mm, 1.7 μm), mobile phase composed of DW(containing 0.1% formic acid): acetonitrile(containing 0.1% formic acid), binary pump at a flow rate of 0.3 ml/min and 5 μl of injection volume, MS/MS detector with ESI positive mode. The calibration range of five NSAIDs showed linearity(r²≥0.99) at concentration range of 3.125∼200 μg/kg. The recoveries in fortified muscle more than 78.7∼100.3%. The detection limits for meloxicam, ketoprofen, flunixin, carprofen and tolfenamic acid were 3.5, 1.6, 1.7, 9.8 and 4.8 μg/kg, respectively. We also monitored NSAIDs residue in cattle muscle 51 samples. The test results, NSAIDs were all not founded.
Abstract
This study was conducted to determine the content of non-steroidal anti-inflammatory drugs(NSAIDs) in meats available on the Korean markets. The analysis was carried out using following conditions; C18 column(100×2.1 mm, 1.7 μm), mobile phase composed of DW(containing 0.1% formic acid): acetonitrile(containing 0.1% formic acid), binary pump at a flow rate of 0.3 ml/min and 5 μl of injection volume, MS/MS detector with ESI positive mode. The calibration range of five NSAIDs showed linearity(r²≥0.99) at concentration range of 3.125∼200 μg/kg. The recoveries in fortified muscle more than 78.7∼100.3%. The detection limits for meloxicam, ketoprofen, flunixin, carprofen and tolfenamic acid were 3.5, 1.6, 1.7, 9.8 and 4.8 μg/kg, respectively. We also monitored NSAIDs residue in cattle muscle 51 samples. The test results, NSAIDs were all not founded.
참고문헌 (15)
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