액상과 고상의 프로폴리스를 투여한 비글견의 혈액 검사를 통한안전성 비교 분석
Comparative analysis of the safety of liquid and powder propolis in beagle dogs through blood tests
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
The aim of this study was to assess and compare the toxicity and safety of two types of propolis (liquid and powder) in beagle dogs. Blood counts, serum biochemistry, and electrolyte tests were conducted to evaluate acute oral toxicity. Propolis was administered at a 5% concentration and 40 g dosage, and the beagles were monitored for 8 weeks. Three beagles served as controls, while four beagles each were assigned to the liquid and powder groups. No significant clinical signs or changes in feed intake, water consumption, body condition, or hematological/biochemical parameters were observed. The results indicate that oral administration of both liquid and powder propolis does not induce toxicological effects in beagle.
Abstract
The aim of this study was to assess and compare the toxicity and safety of two types of propolis (liquid and powder) in beagle dogs. Blood counts, serum biochemistry, and electrolyte tests were conducted to evaluate acute oral toxicity. Propolis was administered at a 5% concentration and 40 g dosage, and the beagles were monitored for 8 weeks. Three beagles served as controls, while four beagles each were assigned to the liquid and powder groups. No significant clinical signs or changes in feed intake, water consumption, body condition, or hematological/biochemical parameters were observed. The results indicate that oral administration of both liquid and powder propolis does not induce toxicological effects in beagle.
참고문헌 (12)
- Ayad AS, "Assessment of efficacy of Algerian propolis against the parasitic mite Varroa destructor and safety for honey bees by spray treatment", Insects, 15(1), pp.75~ (2024)
- Berretta AA, "Development and characterization of new green propolis extract formulations as promising candidates to substitute for green propolis hydroalcoholic extract", Molecules, 28(8), pp.3510~ (2023)
- Braakhuis A, "Evidence on the health benefits of supplemental propolis", Nutrients, 11(11), pp.2705~ (2019)
- Devequi-Nunes D, "Chemical characterization and biological activity of six different extracts of propolis through conventional methods and supercritical extraction", PLoS One, 13(12), pp.e0207676~ (2018)
- Glausiusz J, "How dogs became humans’ best friends : from Neanderthals to now", Nature, 599(7886), pp.553~554 (2021)
- Kim J, "Association between companion animal ownership and overall life satisfaction in Seoul, Korea", PLoS One, 16(9), pp.e0258034~ (2021)
- Kim SK, "Biological properties of propolis isolated from honeybees", J Life Sci, 31(7), pp.686~697 (2021)
- Kubiliene L, "Alternative preparation of propolis extracts : Comparison of their composition and biological activities", BMC Complement Altern Med, 15, pp.156~ (2015)
- Marcial-Modesto D, "Pet ownership and mental health in United States adults during COVID-19", Front Psychol, 14, pp.1217059~ (2023)
- Ripari N, "Propolis antiviral and immunomodulatory activity : A review and perspectives for COVID-19 treatment", J Pharm Pharmacol, 73(3), pp.281~299 (2021)
- Siheri W, "Bee products - Chemical and biological properties", pp.137~178 (2017), Springer
- Svetikiene D, "The comparative study of the antioxidant and antibacterial effects of propolis extracts in veterinary medicine", Vet Sci, 11(8), pp.375~ (2024)
