Trace element and cytokine imbalances in calves with dermatophytosis
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Bovine dermatophytosis is a highly contagious disease that adversely affects animal growth and reduces meat and milk production. Nutritional deficiencies and immune status are suspected risk factors, but their roles remain unclear. This study investigates the association between trace minerals, vitamins, serum biochemical parameters, and immune-related cytokines with bovine dermatophytosis. Forty calves aged 6∼7 months were selected and raised together on the same farm. They were divided into two groups: the control group (n=20) and the infected group (n=20). Serum was collected and analyzed for serum trace minerals, vitamins, biochemical parameters, and cytokine levels. Trichophyton verrucousm was isolated from infected calves. The infected calves had significantly lower zinc (P<0.001) and vitamin E (P=0.02) levels and significantly higher interleukin (IL)-6 (P=0.014) and IL-17A (P=0.018) levels. Regarding serum biochemical parameters, glucose (P=0.008) and total bilirubin (P=0.003) levels were significantly higher in the infected calves than in healthy ones. Hyperglobulinemia and high alkaline phosphatase levels were observed in the infected calves, without statistical significance. Our findings suggest the necessity of considering nutritional elements such as zinc and vitamin E for the prevention and treatment of bovine dermatophytosis. Additionally, the observed changes in immune and serum biochemistry factors post-infection may provide a foundation for future research on the host’s biological responses to infection.
Abstract
Bovine dermatophytosis is a highly contagious disease that adversely affects animal growth and reduces meat and milk production. Nutritional deficiencies and immune status are suspected risk factors, but their roles remain unclear. This study investigates the association between trace minerals, vitamins, serum biochemical parameters, and immune-related cytokines with bovine dermatophytosis. Forty calves aged 6∼7 months were selected and raised together on the same farm. They were divided into two groups: the control group (n=20) and the infected group (n=20). Serum was collected and analyzed for serum trace minerals, vitamins, biochemical parameters, and cytokine levels. Trichophyton verrucousm was isolated from infected calves. The infected calves had significantly lower zinc (P<0.001) and vitamin E (P=0.02) levels and significantly higher interleukin (IL)-6 (P=0.014) and IL-17A (P=0.018) levels. Regarding serum biochemical parameters, glucose (P=0.008) and total bilirubin (P=0.003) levels were significantly higher in the infected calves than in healthy ones. Hyperglobulinemia and high alkaline phosphatase levels were observed in the infected calves, without statistical significance. Our findings suggest the necessity of considering nutritional elements such as zinc and vitamin E for the prevention and treatment of bovine dermatophytosis. Additionally, the observed changes in immune and serum biochemistry factors post-infection may provide a foundation for future research on the host’s biological responses to infection.
참고문헌 (31)
- Al-Ani F, "Ringworm infection of cattle and horses in Jordan", Acta Veterinaria Brno, 71, pp.55~60 (2002)
- Al-Qudah KM, "Trace minerals status and antioxidant enzymes activities in calves with dermatophytosis", Biol Trace Elem Res, 136, pp.40~47 (2010)
- Almeida SR, "Immunology of dermatophytosis", Mycopathologia, 166, pp.277~283 (2008)
- Antachopoulos C, "Cytokines and fungal infections", Br J Haematol, 129, pp.583~596 (2005)
- Atakisi E, "Adenosine deaminase and biochemical liver function tests in the dermatophytic cattle", Bull Vet Inst Pulawy, 50, pp.481~430 (2006)
- Balikci E, "Antidermatophyte and antioxidant activities of Nigella sativa alone and in combination with enilconazole in treatment of dermatophytosis in cattle", Veterinární medicína, 61, pp.539~545 (2016)
- Betul AY, "Evaluation of biochemical parameters and oxidative stress in native and crossbred cattle naturally infected with Dermatophytosis", GSC Biol Pharm Sci, 13, pp.99~104 (2020)
- Blackmon DM, "Zinc deficiency in ruminants. Occurrence, effects, diagnosis and treatments", Vet Med Small Anim Clin, 62, pp.265~270 (1967)
- Burstein VL, "Skin immunity to dermatophytes : From experimental infection models to human disease", Front Immunol, 11, pp.605644~ (2020)
- Chase CC, "Neonatal immune development in the calf and its impact on vaccine response", Vet Clin North Am Food Anim Pract, 24, pp.87~104 (2008)
- Dalis JS, "Prevalence and distribution of dermatophytosis lesions on cattle in Plateau State, Nigeria", Vet World, 12, pp.1484~1490 (2019)
- Davies SJ, "An evaluation of nutritional and therapeutic factors affecting pre-weaned calf health and welfare, and direct-fed microbials as a potential alternative for promoting performance—a review", Dairy, 3, pp.648~667 (2022)
- Glowacka E, "IL-8, IL-12 and IL-10 cytokines generation by neutrophils, fibroblasts and neutrophils-fibroblasts interaction in psoriasis", Adv Med Sci, 55, pp.254~260 (2010)
- Hameed K, "Trichophyton verrucosum infection in livestock in the Chitral district of Pakistan", J Infect Dev Ctries, 11, pp.326~333 (2017)
- Jankovic D, "IL-10 production by CD4+ effector T cells : a mechanism for selfregulation", Mucosal Immunol, 3(3), pp.239~246 (2010)
- Kabu M, "The levels of some biochemical parameters in Anatolian buffaloes with trichophytosis", Kocatepe Vet J, 11(2), pp.156~159 (2018)
- Kesler KW, "Zinc about it-zinc and calf immunity", Front Immunol, 15, pp.1387950~ (2024)
- Kojouri GA, "Zinc and selenium status in cows with dermatophytosis", Comp Clin Path, 18, pp.283~286 (2009)
- Krametter-Froetscher R, "Zinc-responsive dermatosis in goats suggestive of hereditary malabsorption : two field cases", Vet Dermatol, 16, pp.269~275 (2005)
- Laur N, "ICP-MS trace element analysis in serum and whole blood", PLoS One, 15, pp.e0233357~ (2020)
- Lee HG, "The effect of bovine dermatophytosis on auction price in Hanwoo calves", Korean J vet Serv, 46(3), pp.243~247 (2023)
- Lu JM, "Chemical and molecular mechanisms of antioxidants : experimental approaches and model systems", J Cell Mol Med, 14, pp.840~860 (2010)
- Moore KW, "Interleukin-10 and the interleukin-10 receptor", Annu Rev Immunol, 19, pp.683~765 (2001)
- Nisbet C, "Effects of trichophytosis on serum zinc levels in calves", Biol Trace Elem Res, 113, pp.273~279 (2006)
- Otter A, "Diagnostic blood biochemistry and haematology in cattle", In Pract, 35, pp.7~16 (2013)
- Paryuni AD, "Dermatophytosis in companion animals : A review", Vet World, 13, pp.1174~1181 (2020)
- Rickard BF, "Facial eczema : zinc responsiveness in dairy cattle", N Z Vet J, 23, pp.41~42 (1975)
- Rippon JW, "Medical mycology; the pathogenic fungi and the pathogenic actinomycetes" (1989), WB Saunders Co
- Sezer K, "Assessment of oxidative stress, trace elements, serum biochemistry, and hormones levels in weaned calves with dermatophytosis", J Hellenic Vet Med Soc, 72, pp.2653~2660 (2021)
- Spears JW, "Micronutrients and immune function in cattle", Proc Nutr Soc, 59, pp.587~594 (2000)
- Wintergerst ES, "Contribution of selected vitamins and trace elements to immune function", Ann Nutr Metab, 51, pp.301~323 (2007)