프로폴리스를 급여한 비글개에서 혈액수치와 혈청생화학검사를 통한 안전성 분석
Safety test for propolis in beagle dogs based on hematology and serum biochemistry analysis
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
The objective of this study was to determine the safety test for propolis in Beagle based on blood count, serum biochemistry, and electrolyte. Total six beagle dogs were assigned to this experiment. To inves-tigate the safety of propolis in beagle dogs, we performed oral administration of propolis (5%) for 8 weeks. Among six beagles, three beagle dogs were randomly allocated to the control group which were fed only regular fodder, and the other three dogs were assigned as the treatment group which were fed regu-lar fodder and propolis (5%). No clinical signs were observed in neither group throughout the experi-mental period. During the experimental period, there were no significant change in feed intake, water consumption, and body condition. Also, there were no statistically significant differences in hematologi-cal and biochemical analyses between the control group and the treated group. Our safety study showed that oral consumption of propolis did not cause any toxicological effects in beagle dogs.
Abstract
The objective of this study was to determine the safety test for propolis in Beagle based on blood count, serum biochemistry, and electrolyte. Total six beagle dogs were assigned to this experiment. To inves-tigate the safety of propolis in beagle dogs, we performed oral administration of propolis (5%) for 8 weeks. Among six beagles, three beagle dogs were randomly allocated to the control group which were fed only regular fodder, and the other three dogs were assigned as the treatment group which were fed regu-lar fodder and propolis (5%). No clinical signs were observed in neither group throughout the experi-mental period. During the experimental period, there were no significant change in feed intake, water consumption, and body condition. Also, there were no statistically significant differences in hematologi-cal and biochemical analyses between the control group and the treated group. Our safety study showed that oral consumption of propolis did not cause any toxicological effects in beagle dogs.
참고문헌 (25)
- Abdel-Fattah NS, "Effect of Propolis versus Metronidazole and Their Combined Use in Treatment of Acute Experimental Giardiasis", J Egypt Soc Parasitol, 37, pp.691~710 (2007)
- Abu-Seida AM, "Effect of Propolis on experimental cutaneous wound healing in dogs", Vet Med Int, 2015, pp.1~4 (2015)
- Alfaris A, "Comparative studies between propolis, dexametason and gentamycin treatments of induced corneal ulcer in rabbits", Iraqi J Vet Sci, 23, pp.S75~S80 (2009)
- Arvouet-Grand A, "Propolis Extract. Part 6. Subacute toxicity and cutaneous primary irritation index", J Pharm Belg, 48, pp.165~170 (1993)
- Ashry E, "Review the use of propolis as vaccine’s adjuvant", Vaccine, 31, pp.31~39 (2012)
- Babinska I, "Effect of feed supplementation with propolis or liver and kidney morphology in broiler chickens", Pak Vet J, 33(1), pp.1~4 (2014)
- Bassani-Silva S, "Propolis Effect in vitro on canine transmissible venereal tumor cells", Revista Portuguesa de Ciencias Vet, 102, pp.261~265 (2007)
- Betancourt B, "Propolis in dogs clinical experiences and perspectives a brief review", Open J Vet Med, 5, pp.11~17 (2015)
- Bogdanov S., "Propolis composition, health, medicine: a review", Bee Product Sci, pp.1~40 (2014)
- Burdock GA, "Review of the Biological Properties and Toxicity of Bee Propolis(Propolis)", Food and Chemical Toxicology, 36, pp.347~363 (1998)
- DiUlio M, "Veterinary immunology and serology : clinical laboratory diagnostics", Lab Med, 30, pp.36~40 (1999)
- Gross GS, "Perfil de flavonoides e índices de oxidación de algunos propóleoscolombianos", Zootecnia Trop, 25, pp.95~102 (2007)
- Hrytsenko VI, "Study of the polysaccharide preparation propolis", Farm Zh, 32, pp.92~93 (1977)
- Kaneeda J, "Safety of propolis. acute toxicity", Honeybee Science, 15, pp.29~33 (1994)
- Kaneko JJ, , Clinical Biochemistry of Domestic Animals, 4, pp.2~7 (1989)
- Lee HS, "Effects of soybean germ on the lipid composition of serum in cholestrol fed rats", Korean J Food & Nutr, 13, pp.312~318 (2000)
- Lozina L, "Eficacia del propóleos sobre Malassezia pachydermatis correlación de distintas técnicas in vitro", Acta Farm. Bonaerense, 25, pp.560~563 (2006)
- Lumsden JH, ""Normal"or reference values : questions and comments", Vet Clin Pathol, 27, pp.102~106 (1998)
- Monteescu C, "Apiphytotherapeutic product used for nutritional therapy in dogs with liver disease", Economics, Management, and Financial Markets, 6, pp.1175~1178 (2011)
- Mujica V, "The Role of propolis in oxidative stress and lipid metabolism : a randomized controlled trial", Evid Based Complement Alternat Med, 2017, pp.1~11 (2017)
- Pieri FA, "Periodontal disease in dogs", A Bird’s-Eye View of Veterinary Medicine, pp.119~136 (2012)
- Sánchez C, "Use of propolis for tropical treatment of dermatophytosis in dog", Open J Vet Med, 4, pp.239~245 (2014)
- Seven PT, "Effects of propolis on selected blood indicators and antioxidant enzyme activities in broilers under heat stress", Acta Vet. Brno, 78, pp.75~83 (2009)
- Sforcin JM, "Propolis and the immune system : a review", J Ethnoph, 113, pp.1~14 (2007)
- Solberg HE, "Establishment and use of reference values", Tietz' Textbook of Clinical Chemistry, 3, pp.336~356 (1999)