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Antioxidant Effect of Flavonoids Isolated from theRoot of Clematis trichotoma Nakai.

Phuong Thien Thuong|Tran Manh Hung|배기환
한국약용작물학회|2005.10|한국약용작물학회지 (KOREAN JOURNAL OF MEDICINAL CROP SCIENCE)|제13권 제5호|pp. 227-232

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Abstract

The antioxidant effect of methanol extract (ME) and water extract (WE) from Clematis trichotoma was evaluated as primary study to scavenge stable 1,1-diphenyl-2-picrylhydrazyl radicals (DPPH), inhibited iron-induce lipid peroxidation in linoleic acid emulsion, peroxidation of liposome induced by Fe3+/H2O2/ascorbic acid, and on Fe2+/H2O2 induced the mitochondrial lipid peroxidation. In secondary study, five flavonoids as luteolin (1), quercetin (2), apigenin (3), hirsutrin (4), kaempferol-3-O-glucoside were isolated (5). Among them, compounds 1 and 2 showed good activities in all the model systems. Compound 3 exhibited moderate antioxidant activities in both radical scavenging and these lipid peroxidation systems tested. Compound 4 showed significant inhibitions in liposome peroxidation and compound 5 displayed weak inhibition in all four tested systems. All the results presented herein indicate that products of C. trichotoma maybe useful in inhibiting membrane lipid peroxidation and preventing free radical-linked diseases.

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