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Assessment on Antioxidant Properties of Oplopanax elatus Nakai in vitro

권용수|이주경|김재광|이한신|유창연|김명조|엄석현|김준형
한국약용작물학회|2007.04|한국약용작물학회지 (KOREAN JOURNAL OF MEDICINAL CROP SCIENCE)|제15권 제2호|pp. 112-119

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참고문헌

키워드

DPPHantioxidantOplopanax elatusPhenolic compound.

초록

Effects of Oplopanax elatus have known to various pharmaceutical therapies. However, chemical prosperities in the plant are rarely investigated. In order to detect biological activity, we evaluated the antioxidant activity of five fractions from methanolic extracts in each part of O. elatus. Also, contents of polyphenols and polysaccharides were measured. Five fractions were of sub-fractions using n-hexane, ethyl-acetate, n-butanol, and water from methanolic extracts. Ethylacetate and nbutanol fractions from stem and root exhibited strong antioxidant activity and high total phenolics content. On the HPLC analysis, ten free phenolics, including p-hydroxybenzoic acid, chlorogenic acid, caffeic acid, syringic acid, p-coumaric acid, ferulic acid, naringin, hesperidin, quercetin and trans-cinnamic acid, were identified from the fractions and were shown to different quantitative proportions. Furthermore, ethylacetate and n-butanol fraction had the highest amount of chlorogenic acids, one of the cinnamic acid derivatives possessing pharmacological properties. These results indicated that the fractions of O. elatus, as well as methanolic extracts, could be used as natural antioxidative ingredients.

Abstract

Effects of Oplopanax elatus have known to various pharmaceutical therapies. However, chemical prosperities inthe plant are rarely investigated. In order to detect biological activity, we evaluated the antioxidant activity of five fractionsfrom methanolic extracts in each part of O. elatus. Also, contents of polyphenols and polysaccharides were measured. Five fractionswere of sub-fractions using n-hexane, ethyl-acetate, n-butanol, and water from methanolic extracts. Ethylacetate and nbutanolfractions from stem and root exhibited strong antioxidant activity and high total phenolics content. On the HPLCanalysis, ten free phenolics, including p-hydroxybenzoic acid, chlorogenic acid, caffeic acid, syringic acid, p-coumaric acid, ferulicacid, naringin, hesperidin, quercetin and trans-cinnamic acid, were identified from the fractions and were shown to differentquantitative proportions. Furthermore, ethylacetate and n-butanol fraction had the highest amount of chlorogenic acids,one of the cinnamic acid derivatives possessing pharmacological properties. These results indicated that the fractions of O. elatus,as well as methanolic extracts, could be used as natural antioxidative ingredients.

참고문헌 (29)

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