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강화 사자발쑥의 항암활성 증진을 위한 추출조건의 최적화

Optimal Extract Condition for the Enhancement of Anticancer Activities of Artemisia princeps Pampanini

김효정|이상희|이현용|김철희|최근표|박욱연|권민철|유상권
한국약용작물학회|2007.08|한국약용작물학회지 (KOREAN JOURNAL OF MEDICINAL CROP SCIENCE)|제15권 제4호|pp. 233-240

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Abstract

Extractions of Artemisia princeps Pampanini were obtained by using water and ethanol at different temperatures (60℃, 100℃) with or without ultrasonification process (40 ㎑). Yield of ultrasonificated extracts were about 20% higher than that of control group. Cytotoxicity of all conditions through adding 1.0 ㎎/㎖ was below 37%, and treated with ultrasonification group was lower than the other group, about 5~8%. 100℃ water extract with ultrasonification was higher anticancer activities as maximum 73% and higher selectivities at concentrations over 0.8㎎/㎖. The extracts treated with ultrasonification were higher anticancer activities than the control. Densitometric analysis of bcl-2 revealed that extracts of high anticancer activity had low density. This results suggest that expression of bcl-2 protein by adding of Artemisia princeps Pampanini extracts relative to taking cancer. To conclude, optimum condition for efficient extraction of Artemisia princeps Pampanini is using water with ultrasonification at over 60℃ below 100℃.

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관련 논문AI추천

사자발쑥에 포함된 유파티린의 추출 및 정제김은철, 한순구, 노경호*대한화학회 · 대한화학회지2005 · 제49권 제2호사철쑥 추출물의 면역세포의 생육증진 및 세포독성이미경한국약용작물학회 · 한국약용작물학회지2004 · 제12권 제1호족제비싸리 부위별 추출물의 항암 및 면역활성권민철, 김대호, 김정화, 유진현, 이학주, 이현용, 이현정한국약용작물학회 · 한국약용작물학회지2005 · 제13권 제1호초음파 병행추출을 이용한 가시오갈피, 마황, 복분자 및 인진쑥의 항암활성 증진박진홍한국약용작물학회 · 한국약용작물학회지2004 · 제12권 제4호중국 및 국산 백화사설초의 항암활성과 지표물질 연구김성훈, 러정찬, 송규용, 안규석, 이효정한의병리학회 · 동의생리병리학회지2003 · 제17권 제4호파삼의 항암활성 증진이 가능한 고압 추출 공정김영, 김승섭, 유광원, 이현용, 정명훈, 정재현, 정헌상, 하지혜한국약용작물학회 · 한국약용작물학회지2009 · 제17권 제6호

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