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털부처꽃 채취부위별 추출물이 만성 알코올 투여 흰쥐에 미치는 영향

Effect of Plant Part Extracts of Lythrum salicaria L. on Chronically Alcohol-Administrated Rat

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초록

The study was done to investigate the effects of the extracts from the different parts of Lythrum salicaria (LS)on liver protective activities in chronically alcohol-treated rats. SD male rats except normal animals were administrated with alcohol (30 ㎖ of 30%~40% ethanol/㎏/day) and the extracts (300 ㎎/㎏/day) for 10 weeks. Chronic alcohol administration decreased body weight, high density lipoprotein (HDL)-cholesterol and the reduced form-glutathione (GSH), whereas increased the ethanol content, glutamic-oxaloacetic transaminase (GOT), total cholesterol, low density lipoprotein (LDL)-cholesterol, triglyceride in blood/serum and the ratio of the oxidized form of glutathione (GSSG) and total GSH (GSSG/total GSH) in liver tissue. Groups treated with the extracts of leaf, root and stem, showed decrease in GOT, total cholesterol and GSSG/total GSH and increase in hepatic aldehyde dehydrogenase (ALDH), total GSH and serum albumin. Administration with the root extract of LS decreased blood ethanol content compared with the other part extracts. But, serum triglyceride values in rats treated with root and stem extract were higher than that of the negative control animals. Flower extract-fed group showed decrease in body weight and serum triglyceride, but increase in the ratio of GOT and glutamic-pyruvic transaminase (GPT), and GSSG/total GSH. From the results, we conclude that the extracts of root and leaf among the plant parts of LS might be useful for the amelioration of the chronic alcohol-induced liver demage of rat.

Abstract

The study was done to investigate the effects of the extracts from the different parts of Lythrum salicaria (LS)on liver protective activities in chronically alcohol-treated rats. SD male rats except normal animals were administrated with alcohol (30 ㎖ of 30%~40% ethanol/㎏/day) and the extracts (300 ㎎/㎏/day) for 10 weeks. Chronic alcohol administration decreased body weight, high density lipoprotein (HDL)-cholesterol and the reduced form-glutathione (GSH), whereas increased the ethanol content, glutamic-oxaloacetic transaminase (GOT), total cholesterol, low density lipoprotein (LDL)-cholesterol, triglyceride in blood/serum and the ratio of the oxidized form of glutathione (GSSG) and total GSH (GSSG/total GSH) in liver tissue. Groups treated with the extracts of leaf, root and stem, showed decrease in GOT, total cholesterol and GSSG/total GSH and increase in hepatic aldehyde dehydrogenase (ALDH), total GSH and serum albumin. Administration with the root extract of LS decreased blood ethanol content compared with the other part extracts. But, serum triglyceride values in rats treated with root and stem extract were higher than that of the negative control animals. Flower extract-fed group showed decrease in body weight and serum triglyceride, but increase in the ratio of GOT and glutamic-pyruvic transaminase (GPT), and GSSG/total GSH. From the results, we conclude that the extracts of root and leaf among the plant parts of LS might be useful for the amelioration of the chronic alcohol-induced liver demage of rat.

참고문헌 (39)

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털부처꽃 뿌리 추출물의 단회투여가 급성 알코올 투여 흰쥐의 간기능에 미치는 영향김금숙, 김승유, 노형준, 박춘근, 이승은, 이정훈, 홍윤표한국약용작물학회 · 한국약용작물학회지2012 · 제20권 제5호Antioxidative and Hepatoprotective Effects of Lythrum salicaria박춘근, 성낙술, 손영득, 안영섭, 이승은, 차선우한국약용작물학회 · 한국약용작물학회지2009 · 제17권 제1호털부처꽃 뿌리로부터 조제된 분획물의 생리활성김금숙, 김영옥, 김영철, 성낙술, 이상원, 이승은, 이은숙, 이정훈, 한희선한국약용작물학회 · 한국약용작물학회지2010 · 제18권 제5호Antioxidant and Anti-fibrotic Properties of Root Extract of Lythrumsalicaria L. in CCL4-Induced Liver Fibrosis Rat Model김금숙, 김영옥, 박충범, 박호기, 서진숙, 성낙술, 안태진, 이승은, 정해영, 차선우, 한희선한국약용작물학회 · 한국약용작물학회지2009 · 제17권 제4호털부처꽃 에탄올 추출물이 고지방식이를 급여한 흰쥐의 지질대사 및 항비만에 미치는 영향권창주, 김경희, 김성문, 김희연, 박동식, 박유화, 박충범, 이광재, 임상현한국약용작물학회 · 한국약용작물학회지2011 · 제19권 제5호한약재 추출물 함유 음료가 알코올 투여 흰쥐의 알코올 대사 관련 효소에 미치는 영향허담, 김미려, 박현진, 이진상, 최혜민, 황수정한의병리학회 · 동의생리병리학회지2010 · 제24권 제4호

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